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pro vyhledávání: '"Thomas M. Judge"'
Therapeutics developed and sold as racemates can exhibit a limited therapeutic index because of side effects resulting from the undesired enantiomer (distomer) and/or its metabolites, which at times, forces researchers to abandon valuable scaffolds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cd7d1920547a8a7af6ae2847dcd121
https://europepmc.org/articles/PMC4378388/
https://europepmc.org/articles/PMC4378388/
Autor:
Cheney Bv, Steve A. Mizsak, Lester A. Dolak, W. Watt, John Tulinsky, Thomas M. Judge, Ronald B. Gammill, Fusen Han
Publikováno v:
The Journal of Organic Chemistry. 64:93-100
Cyclization of (S,S)-alpha-[(1-phenylethyl)amino]-alpha-(2-iodophenyl)acetonitrile with (COCl)(2) in toluene or chlorobenzene afforded the atropisomeric pyrazinone (aS,S) 6-(2-alpha-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone in 57% y
Publikováno v:
Tetrahedron. 53:11211-11222
An alternative method for the synthesis of 2-amino-5,6-dihydro-4H-pyran-4-ones and 5,6-dihydro-4H-pyran-4-ones is described. This preparation makes use of the condensation of titanium enolates derived from β-hydroxy ketones with phosgene iminium chl
Autor:
Suvit Thaisrivongs, Harvey I. Skulnick, Steve R. Turner, Joseph W. Strohbach, Ruben A. Tommasi, Paul D. Johnson, Paul A. Aristoff, Thomas M. Judge, Ronald B. Gammill, Jeanette K. Morris, Karen R. Romines, Robert A. Chrusciel, Roger R. Hinshaw, Kong-Teck Chong, W. Gary Tarpley, Susan M. Poppe, David E. Slade, Janet C. Lynn, Miao-Miao Horng, Paul K. Tomich, Eric P. Seest, Lester A. Dolak, W. Jeffrey Howe, Gina M. Howard, Francis J. Schwende, Lisa N. Toth, Guy E. Padbury, Grace J. Wilson, Lihua Shiou, Gail L. Zipp, Karen F. Wilkinson, Bob D. Rush, Mary J. Ruwart, Kenneth A. Koeplinger, Zhiyang Zhao, Serena Cole, Renee M. Zaya, Thomas J. Kakuk, Musiri N. Janakiraman, Keith D. Watenpaugh
Publikováno v:
Journal of Medicinal Chemistry. 39:4349-4353
Autor:
William Watt, Ronald B. Gammill, Stephen A. Mizsak, Lester A. Dolak, Thomas M. Judge, John Tulinsky
Publikováno v:
Tetrahedron Letters. 36:2017-2020
Cyclization of ( S , S )- α -[(1-phenylethyl)amino]- α -(2-iodophenyl)acetonitrile 3a with (COCl) 2 in toluene or chlorobenzene afforeded the atropisomeric pyrazinone ( aS , S ) 6-(2-α-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone 7a
Autor:
Lester A. Dolak, Thomas M. Judge, Ronald B. Gammill, Stephen A. Mizsak, William Watt, John Tulinsky
Publikováno v:
ChemInform. 26
Cyclization of ( S , S )- α -[(1-phenylethyl)amino]- α -(2-iodophenyl)acetonitrile 3a with (COCl) 2 in toluene or chlorobenzene afforeded the atropisomeric pyrazinone ( aS , S ) 6-(2-α-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone 7a
Autor:
K. D. Lovasz, Karen Rene Romines, Lester A. Dolak, J. M. Tustin, Gillian Phillips, Thomas M. Judge, R. A. Chrusciel, Strohbach Joseph Walter, Joel Morris, S. L. Vander Velde, G. P. Luke, Steve A. Mizsak, Ronald B. Gammill, John Tulinsky, W. Watt
Publikováno v:
ChemInform. 28
Autor:
Lester A. Dolak, Ronald B. Gammill, John Tulinsky, Fusan Han, Thomas M. Judge, W. Watt, Stephen A. Mizsak, B. Vernon Cheney
Publikováno v:
ChemInform. 30
Autor:
K. D. Lovasz, Stephen A. Mizsak, Thomas M. Judge, Karen Rene Romines, Eric P. Seest, John Tulinsky, Jeanette Kay Morris, Ronald B. Gammill, Fusen Han
Publikováno v:
ChemInform. 30
Publikováno v:
The Journal of Organic Chemistry. 55:3679-3682