Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Thomas M. Jeitner"'
Publikováno v:
Translational Oncology, Vol 22, Iss , Pp 101450- (2022)
The validation of prostate specific membrane antigen (PSMA) as a molecular target in metastatic castration-resistant prostate cancer has stimulated the development of multiple classes of theranostic ligands that specifically target PSMA. Theranostic
Externí odkaz:
https://doaj.org/article/1b2c96b4f70244afb417a188da40e024
Autor:
James M. Kelly, Thomas M. Jeitner, Nicole N. Waterhouse, Wenchao Qu, Ethan J. Linstad, Banafshe Samani, Clarence Williams, Anastasia Nikolopoulou, Alejandro Amor-Coarasa, Stephen G. DiMagno, John W. Babich
Publikováno v:
Molecules, Vol 27, Iss 5, p 1552 (2022)
Cancer cells require lipids to fulfill energetic, proliferative, and signaling requirements. Even though these cells can take up exogenous fatty acids, the majority exhibit a dependency on de novo fatty acid synthesis. Fatty acid synthase (FASN) is t
Externí odkaz:
https://doaj.org/article/3c359e76b2464d68aabac98b8253548d
Autor:
Vivek A. Hariharan, Travis T. Denton, Sarah Paraszcszak, Kyle McEvoy, Thomas M. Jeitner, Boris F. Krasnikov, Arthur J. L. Cooper
Publikováno v:
Biology, Vol 6, Iss 2, p 24 (2017)
Many enzymes make “mistakes”. Consequently, repair enzymes have evolved to correct these mistakes. For example, lactate dehydrogenase (LDH) and mitochondrial malate dehydrogenase (mMDH) slowly catalyze the reduction of 2-oxoglutarate (2-OG) to th
Externí odkaz:
https://doaj.org/article/53e26ddf90384bac9b83029b4ccc6e23
Autor:
Arthur J. L. Cooper, Thomas M. Jeitner
Publikováno v:
Biomolecules, Vol 6, Iss 2, p 16 (2016)
Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glut
Externí odkaz:
https://doaj.org/article/bbd7ff359aa149ad8d5f67efa5e80b34
Autor:
Thomas M. Jeitner, Juan A. Azcona, Gene P. Ables, Diana Cooke, Mark C. Horowitz, Pradeep Singh, James M. Kelly, Arthur J. L. Cooper
Publikováno v:
GeroScience.
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the trans
Autor:
Juan A, Azcona, Samantha, Tang, Elizabeth, Berry, Frank F, Zhang, Radha, Garvey, John R, Falck, Michal Laniado, Schwartzman, Tao, Yi, Thomas M, Jeitner, Austin M, Guo
Publikováno v:
J Pharmacol Exp Ther
Compensatory angiogenesis is an important adaptation for recovery from critical ischemia. We recently identified 20-hydroxyeicosatetraenoic acid (20-HETE) as a novel contributor of ischemia-induced angiogenesis. However, the precise mechanisms by whi
Autor:
Thomas M. Jeitner, James M. Kelly
Publikováno v:
Analytical biochemistry. 657
Mammalian transglutaminase 2 exhibits poor long-term stability in solution. Reconstituting lyophilized transglutaminase 2 in solutions containing dithiothreitol and EDTA alone and together with glycerol stabilizes the activity of this enzyme for seve
Autor:
Thomas M. Jeitner
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d033111be1f4946d295f6cdac10e63c
https://doi.org/10.1016/b978-0-12-819460-7.00141-9
https://doi.org/10.1016/b978-0-12-819460-7.00141-9
Publikováno v:
Circulation. 142
Introduction: Compensatory angiogenic response to ischemia is often insufficient in maintaining adequate tissue perfusion resulting in critical limb ischemia and amputation. Identifying a novel mechanism by which angiogenesis occurs in these conditio
Autor:
Stephen G. DiMagno, John W. Babich, Anastasia Nikolopoulou, Shashikanth Ponnala, James M. Kelly, Thomas M. Jeitner, Clarence Williams
Publikováno v:
Molecular imaging and biology. 23(5)
Fibroblast activation protein-α (FAPα) is uniquely expressed in activated fibroblasts, including cancer-associated fibroblasts that populate tumor stroma and contribute to proliferation and immunosuppression. Radiolabeled FAPα inhibitors enable im