Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas M. Jacks"'
Autor:
Susan L. Hill, Gerry Hickey, Kenneth Mohn, Thomas M. Jacks, Bonnie R. Miller, Colin E. Harvey, Bruce Halley, Klaus D. Schleim, William P. Feeney
Publikováno v:
Journal of Veterinary Dentistry. 26:74-81
Tissue distribution, bioavailability, and efficacy of alendronate in preventing progression of resorption of teeth were evaluated in cats. [Butyl-4-14C-]-alendronate accumulates on subgingival tooth and alveolar bone surfaces adjacent to vascularized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a902ddf732550500296673354bb4c06
https://doi.org/10.1177/089875640902600201
https://doi.org/10.1177/089875640902600201
Autor:
Bridget Butler, Thomas M. Jacks, Roy G. Smith, Kang Cheng, Patrick P. Pollard, Wanda W.-S. Chan, Meng-Hsin Chen, Arthur A. Patchett, Liente Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1261-1266
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aedd98125879e2be470e2cd88aede45
https://doi.org/10.1016/s0960-894x(99)00183-3
https://doi.org/10.1016/s0960-894x(99)00183-3
Autor:
Arthur A. Patchett, Zhijian Lu, Bridget Butler, Thomas M. Jacks, Liente Wei, Gerard J. Hickey, Kang Cheng, Wanda W.-S. Chan, Klaus D. Schleim, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3657-3659
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8c3b7539d8b855d96922e120d5b9a5
https://doi.org/10.1016/j.bmcl.2007.04.050
https://doi.org/10.1016/j.bmcl.2007.04.050
Autor:
Klaus D. Schleim, Roy G. Smith, Kristine Prendergast, Lihu Yang, Wanda Chan, Arthur A. Patchett, Greg Morriello, Thomas M. Jacks, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:107-112
Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e526be722ad4697c6cd111e90dddbc
https://doi.org/10.1016/s0960-894x(97)10199-8
https://doi.org/10.1016/s0960-894x(97)10199-8
Autor:
Nancy N. Tsou, Liente Wei, Zhijian Lu, Gerard J. Hickey, Roy G. Smith, Klaus D. Schleim, James R. Tata, Kwan Leung, Arthur A. Patchett, Shuet-Hing Lee Chiu, Wanda W.-S. Chan, Thomas M. Jacks, Bridget Butler, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2319-2324
The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8228b4951c97f924f6505ffa315e8e12
https://doi.org/10.1016/s0960-894x(97)00421-6
https://doi.org/10.1016/s0960-894x(97)00421-6
Autor:
Richard L. Lieber, Denise B. Cuizon, Donald F. Hora, Ravi P. Nargund, Randall L. Mohler, David H. Gershuni, Thomas M. Jacks, William P. Feeney, Klaus D. Schleim, Michelle L. Haven, Michael A. Lopez, Gerard J. Hickey
Publikováno v:
Journal of Orthopaedic Research. 15:519-527
Twenty-two beagles were divided into two equal groups, and the right hindlimb of each animal was immobilized at 105 degrees of knee flexion by external fixation. After 10 weeks of fixation, the device was removed, allowing free mobility for the follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2227a60c19f15c89d08e09fd43c4bd61
https://doi.org/10.1002/jor.1100150407
https://doi.org/10.1002/jor.1100150407
Autor:
Bridget Butler, Wanda W.-S. Chan, Liente Wei, Roy G. Smith, Marcia M. Murphy, Arthur A. Patchett, Kang Cheng, Gerard J. Hickey, Thomas M. Jacks, Ravi P. Nargund, David B. R. Johnston, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:663-668
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df035d623bcfdef04708a98c8911fbc1
https://doi.org/10.1016/s0960-894x(97)00075-9
https://doi.org/10.1016/s0960-894x(97)00075-9
Autor:
Arthur A. Patchett, Mark G. Steiner, Bridget Butler, Wanda W.-S. Chan, Liente Wei, Kang Cheng, Meng-Hsin Chen, Roy G. Smith, Thomas M. Jacks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2163-2168
A series of spiroindane growth hormone secretagogues that vary in their amino side chains is reported. Variations in these side chains markedly affect growth hormone release in vitro and in vivo . The best side chain in this series of secretagogues i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ff10ecfb197cc8d21dd709daaa8d02
https://doi.org/10.1016/0960-894x(96)00394-0
https://doi.org/10.1016/0960-894x(96)00394-0
Autor:
Kang Cheng, James R. Tata, Khaled J. Barakat, Roy G. Smith, Liente Wei, B. Butler, Johnston David B R, Wanda W.-S. Chan, Arthur A. Patchett, Meng-Hsin Chen, Ravi P. Nargund, Thomas M. Jacks, Gerard J. Hickey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1731-1736
SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 revealed that the D-Trp could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues with comparable intrinsic activity but with sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb550cd768e2defd7b3e9512c1a7555c
https://doi.org/10.1016/0960-894x(96)00305-8
https://doi.org/10.1016/0960-894x(96)00305-8
Autor:
Kang Cheng, Roy G. Smith, Kristine Prendergast, Arthur A. Patchett, Klaus D. Schleim, Lihu Yang, Greg Morriello, Wanda Chan, Thomas M. Jacks
Publikováno v:
ChemInform. 29
Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0b4ee6a4c21d5f028151960111ce41
https://doi.org/10.1002/chin.199818151
https://doi.org/10.1002/chin.199818151