Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Thomas M. H. Liu"'
1
A convergent asymmetric synthesis of a growth hormone secretagogue
Autor: Nan Zheng, Purick Robert M, Ralph P. Volante, Joseph J. Lynch, Jennifer L. Keller, Joseph D. Armstrong, Frederick W. Hartner, Kan K. Eng, Thomas M. H. Liu
Publikováno v: Tetrahedron: Asymmetry. 14:3435-3446
Described herein is a convergent asymmetric synthesis of growth hormone secretagogue (GHS) suitable for large-scale preparations. Key features include: (1) an improved method for α-iodination of a lactam; (2) a novel synthesis of a disubstituted ure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85bca124b16f08ede348c6833dc63c5d
https://doi.org/10.1016/j.tetasy.2003.09.022
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2
An efficient asymmetric synthesis of the mercaptopyrrolidine side chain of an important β-methyl carbapenem antibiotic
Autor: Norikazu Ohtake, Frederick W. Hartner, Ralph P. Volante, Jennifer L. Keller, Osamu Okamoto, Shigemitsu Okada, Yasuyuki Imai, Thomas M. H. Liu, Susumu Nakagawa, Ryosuke Ushijima, Joseph J. Lynch, Joseph D. Armstrong
Publikováno v: Tetrahedron Letters. 38:3203-3206
An efficient asymmetric synthesis of the mercaptopyrrolidine side chain 2 1s described. The β-ketoester 4 is hydrogenated diastereoselectively to give the (R)-β-hydroxyester 5. The remaining functional groups are installed via a thiol Mitsunobu rea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0509fbec7a6a183e621549c6552891bf
https://doi.org/10.1016/s0040-4039(97)00613-8
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4
A facile transformation of bicyclic keto esters to bisprotected (±)-8-epithienamycin enol activation
Autor: Robert A. Reamer, Meyer Sletzinger, Ichiro Shinkai, Thomas M. H. Liu
Publikováno v: Tetrahedron Letters. 21:4221-4224
A facile “one-pot” transformation of bicyclic keto ester (2) to bisprotected (±)-8-epithienamycin via enol phosphate activation followed by the addition-elimination reaction of N -protected cysteamine derivative is described.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74b359122e8c12b228cf7decaeb07723
https://doi.org/10.1016/s0040-4039(00)92867-3
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5
A direct transformation of bicyclic keto esters to -formimidoyl thienamycin
Autor: Thomas M. H. Liu, Frederick W. Hartner, Ichiro Shinkai, Meyer Sletzinger, Robert A. Reamer
Publikováno v: Tetrahedron Letters. 23:4903-4906
A convenient direct transformation of p -nitrobenzyl 6-(1′-hydroxyethyl)-1-azabicyclo-(3.2.0)heptane-3,7-dione-2-carboxylate to N -formimidoyl thienamycin utilizing the silylated derivative of N -formimidoyl cysteamine is described.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be04d73060b0698da37d11f36884d88e
https://doi.org/10.1016/s0040-4039(00)85743-3
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6
The synthesis of 3-(1′-hydroxyethyl)-2-azetidinone-4-yl acetic acid via dianion chemistry - an important intermediate in thienamycin total synthesis
Autor: Robert A. Reamer, Meyer Sletzinger, Thomas M. H. Liu, Ichiro Shinkai
Publikováno v: Tetrahedron Letters. 23:4899-4902
A convenient synthesis of 3-(1′-hydroxyethyl)-2-azetidinone-4-yl acetic acid, one of the key intermediates in the thienamycin total synthesis, based on the chemistry of the dianion derived from readily available 2-azetidinone-4-yl acetic acid is de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed157f576da28946fa7e8c06a1b40ee7
https://doi.org/10.1016/s0040-4039(00)85742-1
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