Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas M. D. Sheard"'
Autor:
Miriam E. Hurley, Shihab S. Shah, Thomas M. D. Sheard, Hannah M. Kirton, Derek S. Steele, Nikita Gamper, Izzy Jayasinghe
Publikováno v:
Cells, Vol 13, Iss 1, p 38 (2023)
Coordinated events of calcium (Ca2+) released from the endoplasmic reticulum (ER) are key second messengers in excitable cells. In pain-sensing dorsal root ganglion (DRG) neurons, these events can be observed as Ca2+ sparks, produced by a combination
Externí odkaz:
https://doaj.org/article/ed1be321deb1400ab073fea9567ebdb9
Publikováno v:
Open Biology, Vol 13, Iss 5 (2023)
Rapid release of calcium from internal stores via ryanodine receptors (RyRs) is one of the fastest types of cytoplasmic second messenger signalling in excitable cells. In the heart, rapid summation of the elementary events of calcium release, 'calciu
Externí odkaz:
https://doaj.org/article/b38620d58c964e7a883436349b4db563
Autor:
Thomas M. D. Sheard, Tayla Shakespeare, Rajpinder S. Seehra, Michael E Spencer, Kin M. Suen, Izzy Jayasinghe
Amine-reactive esters of aromatic fluorescent dyes are emerging as imaging probes for nondescript staining of cellular and tissue architectures. We characterised the differential staining patterns of 14 fluorescent dye ester species with varying phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f481f0cd6e61e45d983722ef3895701c
https://doi.org/10.1101/2023.02.21.529394
https://doi.org/10.1101/2023.02.21.529394
Autor:
Camilla Andersen, Yenisleidy de las Mercedes Zulueta Díaz, Jakob L. Kure, Mathias Hessellund Eriksen, Adam Leslie Lovatt, Christoffer Lagerholm, Sebastian Morales, Simon Sehayek, Thomas M. D. Sheard, Paul W. Wiseman, Eva C. Arnspang
Publikováno v:
Analytical Chemistry.
The mechanisms by which angiotensin II type 1 receptor is distributed and the diffusional pattern in the plasma membrane (PM) remain unclear, despite their crucial role in cardiovascular homeostasis. In this work, we obtained quantitative information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b5b37d21d6b9a5c3e915561ad95c23
https://doi.org/10.1021/acs.analchem.2c02720
https://doi.org/10.1021/acs.analchem.2c02720
Autor:
Thomas M. D. Sheard, Miriam E. Hurley, Andrew J. Smith, John Colyer, Ed White, Izzy Jayasinghe
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 377
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical super-resolution microscopy techniques have revealed the nanoscale structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8768e69c07e1c65de75c4cb1a321574
https://doi.org/10.1098/rstb.2021.0316
https://doi.org/10.1098/rstb.2021.0316
Autor:
Kin M. Suen, Thomas M. D. Sheard, Chi-Chuan Lin, Dovile Milonaityte, Izzy Jayasinghe, John E. Ladbury
Many membraneless organelles (MLOs) have been shown to form via liquid-liquid phase separation (LLPS). Light and electron microscopy techniques have been indispensable in the identification and characterization of LLPS MLOs. However, for complex MLOs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::566481411290526f4e533cb6724bac88
https://doi.org/10.1101/2022.05.29.493872
https://doi.org/10.1101/2022.05.29.493872
Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery in cardiomyocytes. Various adaptations of super-resolution microscopy have revealed intricate details of the structure, molecular composition and locations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7520ab6b7d095b2988595c6972bb133
https://doi.org/10.1101/2021.10.21.462365
https://doi.org/10.1101/2021.10.21.462365
Autor:
Thomas M D, Sheard, Izzy, Jayasinghe
Publikováno v:
Methods in cell biology. 161
Resolution is a key feature in microscopy which allows the visualization of the fine structure of cells. Much of the life processes within these cells depend on the three-dimensional (3D) complexity of these structures. Optical super-resolution micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ae8f72f2e4f56321e43953c9c9f6385
https://pubmed.ncbi.nlm.nih.gov/33478687
https://pubmed.ncbi.nlm.nih.gov/33478687
Autor:
Thomas M. D. Sheard, Izzy Jayasinghe
Publikováno v:
Methods in Cell Biology ISBN: 9780128208076
Resolution is a key feature in microscopy which allows the visualization of the fine structure of cells. Much of the life processes within these cells depend on the three-dimensional (3D) complexity of these structures. Optical super-resolution micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d2630195688bc2f61ddfbc0bf9e3ebe
https://doi.org/10.1016/bs.mcb.2020.04.019
https://doi.org/10.1016/bs.mcb.2020.04.019
Autor:
Eleftheria Pervolaraki, Nikita Gamper, Ruth Norman, Izzy Jayasinghe, Thomas M. D. Sheard, Shihab Shah, Miriam E. Hurley, Hannah M. Kirton, Zhaokang Yang, Derek S. Steele, Ed White
Nanometre-scale cellular information obtained through super-resolution microscopies are often unaccompanied by functional information, particularly transient and diffusible signals through which life is orchestrated in the nano-micrometre spatial sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69dfe26707e338fd4199b8fc7e989849
https://doi.org/10.1101/2020.09.29.319400
https://doi.org/10.1101/2020.09.29.319400