Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Thomas M. Cocks"'
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 84-93 (2008)
Protease-activated receptor-2 (PAR2), primarily involved in inflammation, is highly expressed in limbic regions of the brain such as the hippocampus. Although extracellular proteolysis is involved in normal and stress-related neuronal plasticity asso
Externí odkaz:
https://doaj.org/article/165d38f7d731417ab267c68d558c4eee
Publikováno v:
Neurobiology of Learning and Memory. 92:301-309
Serine proteases such as tissue plasminogen activator (tPA), thrombin and neuropsin influence hippocampal plasticity involved in learning and memory by facilitating both synaptic remodelling and long-term potentiation. Given our previous findings tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c63984c04382c0be00be0665bc01b6
https://doi.org/10.1016/j.nlm.2009.03.010
https://doi.org/10.1016/j.nlm.2009.03.010
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 378:33-41
The roles of kinin and protease-activated receptors (PAR) in endothelium-dependent relaxations to the serine protease, trypsin, were examined in rings of bovine left anterior descending coronary artery (LAD). Trypsin (0.01–30 U/ml) caused biphasic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea83be0b7c03608e98515f4c960e6cbd
https://doi.org/10.1007/s00210-008-0291-x
https://doi.org/10.1007/s00210-008-0291-x
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 84-93 (2008)
Protease-activated receptor-2 (PAR(2)), primarily involved in inflammation, is highly expressed in limbic regions of the brain such as the hippocampus. Although extracellular proteolysis is involved in normal and stress-related neuronal plasticity as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f36b9b650d7e14b1b72b68d3b2d30a
https://doi.org/10.1016/j.nbd.2007.12.010
https://doi.org/10.1016/j.nbd.2007.12.010
Protease-Activated Receptor-2 Peptides Activate Neurokinin-1 Receptors in the Mouse Isolated Trachea
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:598-605
Protective roles for protease-activated receptor-2 (PAR(2)) in the airways including activation of epithelial chloride (Cl(-)) secretion are based on the use of presumably PAR(2)-selective peptide agonists. To determine whether PAR(2) peptide-activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42085ef9a0e15d0793fc6eebadbbde88
https://doi.org/10.1124/jpet.105.097121
https://doi.org/10.1124/jpet.105.097121
Publikováno v:
British Journal of Pharmacology. 141:1159-1166
The 5-HT receptor subtype that mediates bronchocontraction and the involvement of neuronal and non-neuronal acetylcholine was assessed in murine isolated tracheae. Atropine (1–10 nM) caused a rightward shift of the methacholine concentration–effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b75738835c9076da919102158eb5ecc
https://doi.org/10.1038/sj.bjp.0705720
https://doi.org/10.1038/sj.bjp.0705720
Publikováno v:
British Journal of Pharmacology. 136:492-501
Protease-activated receptor (PAR)-mediated vascular relaxations have been compared in coronary arteries of different diameters isolated from both humans and pigs. Thrombin, trypsin, and the PAR1-activating peptide, TFLLR, all caused concentration-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4275892518c822aa2804848de2373a
https://doi.org/10.1038/sj.bjp.0704714
https://doi.org/10.1038/sj.bjp.0704714
Publikováno v:
British Journal of Pharmacology. 131:1584-1591
Mechanisms of relaxation and contraction to protease-activated receptor- (PAR) tethered ligand peptides (SFLLRN/TFLLR, SLIGRL and GYPGKF (all C-terminally amidated) for PAR1, PAR2 and PAR4, respectively) and enzymes (thrombin and trypsin) were invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2edcfc52665dc41e92da23a55736b9fa
https://doi.org/10.1038/sj.bjp.0703738
https://doi.org/10.1038/sj.bjp.0703738
Publikováno v:
British Journal of Pharmacology. 130:181-188
1. Mechanisms of protease-activated receptor-1 (PAR1)- and PAR2-induced relaxation were investigated in pre-contracted porcine coronary artery ring preparations. 2. Thrombin (0.01 - 0.3 u ml(-1)) and the PAR1-activating peptide SFLLRN (0.1 - 10 micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49410b0ebf67574843e0da52ac6c7ae6
https://doi.org/10.1038/sj.bjp.0703146
https://doi.org/10.1038/sj.bjp.0703146
Autor:
Thomas M. Cocks, Stavros Selemidis
Publikováno v:
British Journal of Pharmacology. 129:1315-1322
Ryanodine-sensitive, Ca2+ release (‘Ca2+ sparks’) from the sarcoplasmic reticulum (SR) can activate plasmalemmal Ca2+-activated K+ channels (KCa) to cause membrane hyperpolarization and smooth muscle relaxation. Since cyclic guanosine monophospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eab3a1675863daba0d4f34b3ba32d35
https://doi.org/10.1038/sj.bjp.0703174
https://doi.org/10.1038/sj.bjp.0703174