Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Thomas M. Bertolini"'
Autor:
Chun Chow, Daniel Wall, Douglas E. Murphy, Stephen E. Webber, Thomas M. Bertolini, Yuefen Zhou, Zhongxiang Sun, Thomas Hermann, Jamie M. Froelich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3369-3375
Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus towards Pseudomonas aeruginosa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d036dfb8db9d0e1b9ba892ff9d73080a
https://doi.org/10.1016/j.bmcl.2008.04.023
https://doi.org/10.1016/j.bmcl.2008.04.023
Autor:
Frank Ruebsam, Lian-Sheng Li, Jingjing Zhao, Nebojsa Stankovic, Peter S. Dragovich, Zhongxiang Sun, Thomas M. Bertolini, Yuefen Zhou, Benjamin K. Ayida, Douglas E. Murphy
Publikováno v:
Tetrahedron Letters. 49:811-815
A general procedure is described for the preparation of 6-substituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (6-substituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters). These compounds are shown to unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4440dfc10a040a3befedc845e0fee425
https://doi.org/10.1016/j.tetlet.2007.11.187
https://doi.org/10.1016/j.tetlet.2007.11.187
Autor:
Yuefen Zhou, Tran Chinh Viet, Thomas M. Bertolini, Douglas E. Murphy, Peter S. Dragovich, Frank Ruebsam, Stephen E. Webber, Zhongxiang Sun, Lian-Sheng Li, Benjamin K. Ayida, Nebojsa Stankovic, Jingjing Zhao
Publikováno v:
Synthesis. 2007:3301-3308
2,6-Disubstituted 5-hydroxy-3(2 H)-pyridazinone-4-carboxylic acid ethyl esters were synthesized from α-keto esters via an efficient three-step sequence including hydrazone formation, acylation with ethyl malonyl chloride, and subsequent Dieckmann cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de47ae84da131b84c444950c5ef180db
https://doi.org/10.1055/s-2007-990823
https://doi.org/10.1055/s-2007-990823
Publikováno v:
The Journal of Organic Chemistry. 67:8675-8678
Treatment of molybdenum Fischer carbene complexes with 6-methylene-7-octen-1-yne derivatives at 40 degrees C generates substituted tricyclo[4.3.1.0(1,6)]deca-2,4-dienes in good yield. Pentacarbonyl(butylmethoxycarbene)molybdenum(0) afforded the highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea02b9ef35962540ca36d93a98bf327b
https://doi.org/10.1021/jo020378a
https://doi.org/10.1021/jo020378a
Autor:
Frank Ruebsam, Zhongxiang Sun, Peter S. Dragovich, Benjamin K. Ayida, Yuefen Zhou, Lian-Sheng Li, Nebojsa Stankovic, Thomas M. Bertolini, Douglas E. Murphy, Jingjing Zhao
Publikováno v:
ChemInform. 39
A general procedure is described for the preparation of 6-substituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (6-substituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters). These compounds are shown to unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da168f29c5e2b8f18be6162de2fb29a
https://doi.org/10.1002/chin.200820147
https://doi.org/10.1002/chin.200820147
Autor:
Ellen Okamoto, Ruhi Kamran, Leo Kirkovsky, Darian M. Bartkowski, Alberto Gobbi, Jingjing Zhao, Rupal Patel, Lian-Sheng Li, Matthew Lardy, Peter S. Dragovich, Laurie A. LeBrun, Stephen E. Webber, Nebojsa Stankovic, Mei Tsan, Maria V. Sergeeva, Daniel A. Norris, Amit M. Shah, Thomas G. Nolan, Yuefen Zhou, Douglas E. Murphy, Thomas M. Bertolini, Zhongxiang Sun
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(11)
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as potent inhibitors of genotype 1 HCV NS5B polymerase focusing on the optimization of their drug metabolism and pharmacokinetics (DMPK) profiles. This investigation led to the discovery of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8687624dcae92c30dde5e7e4c99b09be
https://pubmed.ncbi.nlm.nih.gov/18442904
https://pubmed.ncbi.nlm.nih.gov/18442904
Autor:
Jingjing Zhao, Frank Ruebsam, Rupal Patel, Douglas E. Murphy, Tran Chinh Viet, Stephen E. Webber, Charles R. Kissinger, Nebojsa Stankovic, Lian-Sheng Li, Darian M. Bartkowski, Richard E. Showalter, Qiang Zhao, Mei Tsan, Benjamin K. Ayida, Zhongxiang Sun, Ruhi Kamran, Leo Kirkovsky, Peter S. Dragovich, Jennifer Brooks, Amit M. Shah, Laurie A. LeBrun, Maria V. Sergeeva, Thomas M. Bertolini, Thomas G. Nolan, Daniel A. Norris, Yuefen Zhou
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(11)
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. Lead optimization led to the discovery of compound 3a, which displayed potent inhibitory activities in biochemical and replicon assays [IC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e51c8e956fdb226b2d076056f8c00c0
https://pubmed.ncbi.nlm.nih.gov/18457949
https://pubmed.ncbi.nlm.nih.gov/18457949
Publikováno v:
The Journal of organic chemistry. 68(13)
Several novel phorbol esters were prepared with polar functional groups terminating their C12 and/or C13 acyl chains. Designed to be inhibitory protein kinase C (PKC) ligands, these phorbol analogues contain various polar functional groups (amide, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347c9e24eb7f62671a42ece8b37c6f33
https://pubmed.ncbi.nlm.nih.gov/12816455
https://pubmed.ncbi.nlm.nih.gov/12816455
Autor:
Thomas M, Bertolini
Publikováno v:
Plastic and reconstructive surgery. 110(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e5924d1b17dd36ea4709dc17b62bd6f
https://pubmed.ncbi.nlm.nih.gov/12832933
https://pubmed.ncbi.nlm.nih.gov/12832933
Autor:
Thomas M. Bertolini, Phuc D. Tran
Publikováno v:
Journal of Chemical Education. 83:590
A worksheet of 18 reactions is presented as a learning aid to comprehend the regiochemistry and stereochemistry of alkene electrophilic addition. Answering all of the questions correctly rewards students with the answer to a chemistry-themed riddle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f942ae75b1787fd8470a6c6a076c00
https://doi.org/10.1021/ed083p590
https://doi.org/10.1021/ed083p590