Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thomas M. Ash"'
Autor:
Erin L. Pulster, Kylee Rullo, Sherryl Gilbert, Thomas M. Ash, Barbara Goetting, Kevin Campbell, Sara Markham, Steven A. Murawski
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
The primary source of chronic exposures to per- and polyfluoroalkyl substances (PFASs) in humans is through the ingestion of contaminated foods and drinking water, with fish and other seafood being a major contributor. Nevertheless, there is scant li
Externí odkaz:
https://doaj.org/article/895e49f93b24480f80766fa77ad2d6e6
Autor:
Xiang Liu, Wern Hann Ng, Eva Zusinaite, Joseph Freitas, Adam Taylor, Venugopal Yerragunta, Shukra Madhaha Aavula, Sambaiah Gorriparthi, Santhakumar Ponsekaran, Rama Lakshmi Bonda, Priyanka Mani, Sridevi V. Nimmagadda, Sainan Wang, Laura Sandra Lello, Ali Zaid, Ujjwal Dua, Sharon A. Taft-Benz, Elizabeth Anderson, Victoria K. Baxter, Sanjay Sarkar, Zheng L. Ling, Thomas M. Ashhurst, Samuel M. S. Cheng, Priyabrata Pattnaik, Anand Kumar Kanakasapapathy, Ralph S. Baric, Felicity J. Burt, Malik Peiris, Mark T. Heise, Nicholas J. C. King, Andres Merits, Rajendra Lingala, Suresh Mahalingam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) continues its significant health and economic impact globally. Despite the success of spike-protein vaccines in preventing severe disease, long-lasting protection against
Externí odkaz:
https://doaj.org/article/1d058aac3c414955a9f8d09ea4a167c5
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Advancements in cytometry technologies have enabled quantification of up to 50 proteins across millions of cells at single cell resolution. Analysis of cytometry data routinely involves tasks such as data integration, clustering, and dimensi
Externí odkaz:
https://doaj.org/article/a9bd3be5af234d1f83222096912f9606
Autor:
Alanna G. Spiteri, Tamara Suprunenko, Erin Cutts, Andrew Suen, Thomas M. Ashhurst, Barney Viengkhou, Nicholas J. C. King, Markus J. Hofer
Publikováno v:
Viruses, Vol 16, Iss 3, p 390 (2024)
CD8+ T cells are critical to the adaptive immune response against viral pathogens. However, overwhelming antigen exposure can result in their exhaustion, characterised by reduced effector function, failure to clear virus, and the upregulation of inhi
Externí odkaz:
https://doaj.org/article/26022dd0865c4e828fc5dc8f2712d9fb
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Bone marrow (BM)-derived monocytes induce inflammation and tissue damage in a range of pathologies. In particular, in a mouse model of West Nile virus (WNV) encephalitis (WNE), nitric oxide-producing, Ly6Chi inflammatory monocytes from the BM are rec
Externí odkaz:
https://doaj.org/article/aa0789a46c3844e7b056c7f8842c7136
Autor:
Wuji Zhang, Brendon Y. Chua, Kevin J. Selva, Lukasz Kedzierski, Thomas M. Ashhurst, Ebene R. Haycroft, Suzanne K. Shoffner-Beck, Luca Hensen, David F. Boyd, Fiona James, Effie Mouhtouris, Jason C. Kwong, Kyra Y. L. Chua, George Drewett, Ana Copaescu, Julie E. Dobson, Louise C. Rowntree, Jennifer R. Habel, Lilith F. Allen, Hui-Fern Koay, Jessica A. Neil, Matthew J. Gartner, Christina Y. Lee, Patiyan Andersson, Sadid F. Khan, Luke Blakeway, Jessica Wisniewski, James H. McMahon, Erica E. Vine, Anthony L. Cunningham, Jennifer Audsley, Irani Thevarajan, Torsten Seemann, Norelle L. Sherry, Fatima Amanat, Florian Krammer, Sarah L. Londrigan, Linda M. Wakim, Nicholas J. C. King, Dale I. Godfrey, Laura K. Mackay, Paul G. Thomas, Suellen Nicholson, Kelly B. Arnold, Amy W. Chung, Natasha E. Holmes, Olivia C. Smibert, Jason A. Trubiano, Claire L. Gordon, Thi H. O. Nguyen, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The immune response to SARS-CoV-2 infection is variable but has been linked to prognosis and the development of severe immunopathology. Here the authors assess a range of immune parameters in both peripheral blood and respiratory samples, providing a
Externí odkaz:
https://doaj.org/article/3dbf74c705f948919beba2c6dc7dada4
Autor:
Phillip K. West, Andrew N. McCorkindale, Boris Guennewig, Thomas M. Ashhurst, Barney Viengkhou, Emina Hayashida, So Ri Jung, Oleg Butovsky, Iain L. Campbell, Markus J. Hofer
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-27 (2022)
Abstract Background Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is implicated in the pathogenesis of neurological diseases such as neuromyelitis optica spectrum disorders or cereb
Externí odkaz:
https://doaj.org/article/1c51646c0c944947a3bdef07939869db
Autor:
Alanna G. Spiteri, Rachel L. Terry, Claire L. Wishart, Thomas M. Ashhurst, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)
Abstract Background Differentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘microglia-like’ phenot
Externí odkaz:
https://doaj.org/article/ebf58f4e1d3f4998b8f08e4ddf92213b
Autor:
Emina Hayashida, Zheng Lung Ling, Thomas M. Ashhurst, Barney Viengkhou, So Ri Jung, Pattama Songkhunawej, Phillip K. West, Nicholas J. C. King, Markus J. Hofer
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Until the end of the twentieth century, Zika virus (ZIKV) was thought to cause a mostly mild, self-limiting disease in humans. However, as the geographic distribution of ZIKV has shifted, so too has its pathogenicity. Modern-day Z
Externí odkaz:
https://doaj.org/article/448d676df21c488e9a6c3261286bc8dc
Autor:
Thomas M. Ashton, Emmanouil Fokas, Leoni A. Kunz-Schughart, Lisa K. Folkes, Selvakumar Anbalagan, Melanie Huether, Catherine J. Kelly, Giacomo Pirovano, Francesca M. Buffa, Ester M. Hammond, Michael Stratford, Ruth J. Muschel, Geoff S. Higgins, William Gillies McKenna
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sens
Externí odkaz:
https://doaj.org/article/5fcde319119841a9a1a9daedc3b99552