Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Thomas M Rippin"'
Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding
Publikováno v:
Journal of Molecular Biology. 319:351-358
We present an analysis by NMR of a 58 kDa complex of the core domain of the tumour suppressor p53 with DNA that complements and extends the crystal structure analysis. Binding of specific DNA caused significant chemical shifts of residues on the DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef676bec4f6bd06315dde536fcae09c
https://doi.org/10.1016/s0022-2836(02)00326-1
https://doi.org/10.1016/s0022-2836(02)00326-1
Autor:
Mark R. Proctor, Thomas M Rippin, Lars O. Hansson, Penka V. Nikolova, Assaf Friedler, Alan R. Fersht, Dmitry B. Veprintsev, Stefan M.V. Freund, Stefan G.D. Rüdiger
Publikováno v:
Proceedings of the National Academy of Sciences. 99:937-942
Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122628f7bea9f44c4f0a7c1f8a7b24c3
https://doi.org/10.1073/pnas.241629998
https://doi.org/10.1073/pnas.241629998
Autor:
Vladimir J.N. Bykov, Stefan M.V. Freund, Alan R. Fersht, Galina Selivanova, Klas G. Wiman, Thomas M Rippin
Publikováno v:
Oncogene. 21(14)
The Pfizer compound CP-31398 has been reported to stabilize the core domain of the tumour suppressor p53 in vitro and be an effective anti-cancer drug by virtue of rescuing destabilized mutants of p53. We did not detect any interaction between the p5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227f1cd384629f3daa8b474621755b71
https://pubmed.ncbi.nlm.nih.gov/11948395
https://pubmed.ncbi.nlm.nih.gov/11948395