NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail.

Autor: Padraig Gleeson, Sharon Crook, Robert C Cannon, Michael L Hines, Guy O Billings, Matteo Farinella, Thomas M Morse, Andrew P Davison, Subhasis Ray, Upinder S Bhalla, Simon R Barnes, Yoana D Dimitrova, R Angus Silver

Publikováno v: PLoS Computational Biology, Vol 6, Iss 6, p e1000815 (2010)

Biologically detailed single neuron and network models are important for understanding how ion channels, synapses and anatomical connectivity underlie the complex electrical behavior of the brain. While neuronal simulators such as NEURON, GENESIS, MO

Externí odkaz: https://doaj.org/article/d6213c4969c9433db88533de3998fec6

ModelDB

Autor: Robert A. McDougal, Rixin Wang, Thomas M. Morse, Michele Migliore, Luis Marenco, Ted Carnevale, Michael Hines, Gordon M. Shepherd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63bbf010b2194ca8517be719ca9ee0c4
https://doi.org/10.1007/978-1-0716-1006-0_158

PLD3 affects axonal spheroids and network defects in Alzheimer's disease

Autor: Peng, Yuan, Mengyang, Zhang, Lei, Tong, Thomas M, Morse, Robert A, McDougal, Hui, Ding, Diane, Chan, Yifei, Cai, Jaime, Grutzendler

Publikováno v: Nature. 612(7939)

The precise mechanisms that lead to cognitive decline in Alzheimer's disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural network dysfunction. Using intravital calcium and voltage imagin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3cf51dcf8a1983c9223e56980246fa7
https://pubmed.ncbi.nlm.nih.gov/36450951

Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience

Autor: Rixin Wang, Perry L. Miller, Gordon M. Shepherd, Michele Migliore, Michael L. Hines, Luis N. Marenco, Robert A. McDougal, Ted Carnevale, Thomas M. Morse

Publikováno v: Journal of computational neuroscience (Dordr., Online) 42 (2017): 1–10. doi:10.1007/s10827-016-0623-7
info:cnr-pdr/source/autori:McDougal RA, Morse TM, Carnevale T, Marenco L, Wang R, Migliore M, Miller PL, Shepherd GM, Hines ML/titolo:Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience/doi:10.1007%2Fs10827-016-0623-7/rivista:Journal of computational neuroscience (Dordr., Online)/anno:2017/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume:42

Neuron modeling may be said to have originated with the Hodgkin and Huxley action potential model in 1952 and Rall's models of integrative activity of dendrites in 1964. Over the ensuing decades, these approaches have led to a massive development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e755e33e7fa776cc3a17ccea51dce8
https://doi.org/10.1007/s10827-016-0623-7

Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb

Autor: Thomas S. McTavish, Gordon M. Shepherd, Shaina M. Short, Justus V. Verhagen, Thomas M. Morse

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168356 (2016)
PLoS ONE

Respiration plays an essential role in odor processing. Even in the absence of odors, oscillating excitatory and inhibitory activity in the olfactory bulb synchronizes with respiration, commonly resulting in a burst of action potentials in mammalian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0837881d36501b6c521efbae1deb0a65
http://europepmc.org/articles/PMC5179112?pdf=render