Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Thomas M Hyde"'
Autor:
Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich, Stephanie C Hicks
Publikováno v:
eLife, Vol 12 (2024)
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning, and memor
Externí odkaz:
https://doaj.org/article/5535bef8bfda4d938789135e8f5f9d86
Autor:
Eugenia Radulescu, Qiang Chen, Giulio Pergola, Pasquale Di Carlo, Shizhong Han, Joo Heon Shin, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010989 (2023)
The effect of schizophrenia (SCZ) genetic risk on gene expression in brain remains elusive. A popular approach to this problem has been the application of gene co-expression network algorithms (e.g., WGCNA). To improve reliability with this method it
Externí odkaz:
https://doaj.org/article/5b4e1686789a4b1b9371751ae2a7254d
Autor:
Jesper R Gådin, Alfonso Buil, Carlo Colantuoni, Andrew E Jaffe, Jacob Nielsen, Joo-Heon Shin, Thomas M Hyde, Joel E Kleinman, BrainSeq Consortium, Niels Plath, Per Eriksson, Søren Brunak, Michael Didriksen, Daniel R Weinberger, Lasse Folkersen
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217765 (2019)
BackgroundOf the 108 Schizophrenia (SZ) risk-loci discovered through genome-wide association studies (GWAS), 96 are not altering the sequence of any protein. Evidence linking non-coding risk-SNPs and genes may be established using expression quantita
Externí odkaz:
https://doaj.org/article/a6b08c5130b64f28b1d5683ceb39313b
Autor:
Amy Deep-Soboslay, Michelle I Mighdoll, Andrew E Jaffe, Stephen B Thomas, Mary M Herman, Jonathan Sirovatka, Jewell P King, David R Fowler, Dawn Zulauf, Constance DiAngelo, Thomas M Hyde, Joel E Kleinman
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222565 (2019)
Increased African-American research participation is critical to the applicability and generalizability of biomedical research, as population diversity continues to increase both domestically and abroad. Yet numerous studies document historical origi
Externí odkaz:
https://doaj.org/article/d1262c78c031496e9f032e9e32a092de
Autor:
Nikolay A Ivanov, Ran Tao, Joshua G Chenoweth, Anna Brandtjen, Michelle I Mighdoll, John D Genova, Ronald D McKay, Yankai Jia, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyde, Andrew E Jaffe
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005819 (2016)
Differentiating pluripotent cells from fibroblast progenitors is a potentially transformative tool in personalized medicine. We previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from po
Externí odkaz:
https://doaj.org/article/ea18d3fa55e1473aba26f21353a36c82
Autor:
Kasey N Davis, Ran Tao, Chao Li, Yuan Gao, Marjorie C Gondré-Lewis, Barbara K Lipska, Joo Heon Shin, Bin Xie, Tianzhang Ye, Daniel R Weinberger, Joel E Kleinman, Thomas M Hyde
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148558 (2016)
Genetic variation and early adverse environmental events work together to increase risk for schizophrenia. γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in adult mammalian brain, plays a major role in normal brain development, an
Externí odkaz:
https://doaj.org/article/926f2e0d97124c0cbe63aa2c7ed33b09
Autor:
Lindsay A Bliss, Malik R Sams, Amy Deep-Soboslay, Renee Ren-Patterson, Andrew E Jaffe, Josh G Chenoweth, Amritha Jaishankar, Joel E Kleinman, Thomas M Hyde
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45282 (2012)
Fibroblasts can be collected from deceased individuals, grown in culture, reprogrammed into induced pluripotent stem cells (iPSCs), and then differentiated into a multitude of cell types, including neurons. Past studies have generated iPSCs from soma
Externí odkaz:
https://doaj.org/article/9b8fabd544234d1fa85c56a5eb488c92
Autor:
Varsha Agarwal, Reddy P Kommaddi, Khader Valli, Daniel Ryder, Thomas M Hyde, Joel E Kleinman, Henry W Strobel, Vijayalakshmi Ravindranath
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2337 (2008)
Cytochrome P450 (P450) is a super-family of drug metabolizing enzymes. P450 enzymes have dual function; they can metabolize drugs to pharmacologically inactive metabolites facilitating their excretion or biotransform them to pharmacologically active
Externí odkaz:
https://doaj.org/article/0e552eee4d4c4dae9bbeda95d763442d
Autor:
Elin Lehrmann, Carlo Colantuoni, Amy Deep-Soboslay, Kevin G Becker, Ross Lowe, Marilyn A Huestis, Thomas M Hyde, Joel E Kleinman, William J Freed
Publikováno v:
PLoS ONE, Vol 1, p e114 (2006)
A major goal of drug abuse research is to identify and understand drug-induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to exami
Externí odkaz:
https://doaj.org/article/b210f8a81be348b48465fae0a808997f
Autor:
Amanda J. Price, Leonardo Collado-Torres, Nikolay A. Ivanov, Wei Xia, Emily E. Burke, Joo Heon Shin, Ran Tao, Liang Ma, Yankai Jia, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger, Andrew E. Jaffe
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-20 (2019)
Abstract Background DNA methylation (DNAm) is a critical regulator of both development and cellular identity and shows unique patterns in neurons. To better characterize maturational changes in DNAm patterns in these cells, we profile the DNAm landsc
Externí odkaz:
https://doaj.org/article/2d0ac030c90f4a369eb9351bf54f5cdb