Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Thomas M Geiger"'
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Akademický článek
Use of Poly(vinyl alcohol) in Spray-Dried Dispersions: Enhancing Solubility and Stability of Proteolysis Targeting Chimeras
Autor: Lena Mareczek, Lena K. Mueller, Laura Halstenberg, Thomas M. Geiger, Michael Walz, Min Zheng, Felix Hausch
Publikováno v: Pharmaceutics, Vol 16, Iss 7, p 924 (2024)
PROTACs, proteolysis targeting chimeras, are bifunctional molecules inducing protein degradation through a unique proximity-based mode of action. While offering several advantages unachievable by classical drugs, PROTACs have unfavorable physicochemi
Externí odkaz: https://doaj.org/article/d6ee4db072db4e7e933255cf8394415a
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3
Akademický článek
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor: Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro
Externí odkaz: https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
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4
Akademický článek
FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.
Autor: Andreas Hähle, Thomas M Geiger, Stephanie Merz, Christian Meyners, Mao Tianqi, Jürgen Kolos, Felix Hausch
Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0221926 (2019)
The protein factor Glomulin (Glmn) is a regulator of the SCF (Skp1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Mutations of Glmn lead to glomuvenous malformations. Glmn has been reported to be associated with FK506-binding proteins (FKBP
Externí odkaz: https://doaj.org/article/eb801d8576204153a43254d72f82e7ae
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6
Structure-based discovery of a new selectivity-enabling motif for the FK506-binding protein 51
Autor: Fabian H. Knaup, Christian Meyners, Wisely Oki Sugiarto, Saskia Wedel, Margherita Springer, Carlo Walz, Thomas M. Geiger, Mathias Schmidt, Marco Sisignano, Felix Hausch
In recent years the selective inhibition of FKBP51 has emerged as a possible treatment for chronic pain, obesity-induced diabetes, or depression. All currently known advanced FKBP51-selective inhibitors, including the widely used SAFit2, contain a cy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03081ad8bb2b0f20e4cbea12ac38d678
https://doi.org/10.26434/chemrxiv-2023-pzzcv
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7
Large-scale in-cell photocrosslinking at single residue resolution reveals the molecular basis for glucocorticoid receptor regulation by immunophilins
Autor: Asat Baischew, Sarah Engel, Thomas M. Geiger, Felix Hausch
The large immunophilins FKBP51 and FKBP52 play key roles in the Hsp90-mediated maturation of steroid hormone receptors, which is crucial for stress-related disorders and correct sexual embryonic development, respectively1–3. A prominent regulatory
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::229eca0b30494053bd264ab3b6189cc9
https://doi.org/10.1101/2023.01.16.524346
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9
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor: Felix Hausch, Daniel E. Heinz, Valentin Stein, Ulrike Schmidt, Frederik Dethloff, Lee Jollans, Max L. Pöhlmann, Bernhard Kuster, Katja Weckmann, Kathrin Hafner, Elmira Anderzhanova, Svenja Wiechmann, Thomas M. Geiger, Thomas Bajaj, Jakob Hartmann, Tim Ebert, Christoph W. Turck, Nils C. Gassen, Alexandra Philipsen, Mathias V. Schmidt, Susanne Schmidt, Giuseppina Maccarrone, Michael Döngi, Anne-Kathrin Gellner, Silvia Martinelli
Publikováno v: Nature Communications, 12(1):4643. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The stress response is an essential mechanism for maintaining homeostasis, and its disruption is implicated in several psychiatric disorders. On the cellular level, stress activates, among other mechanisms, autophagy that regulates homeostasis throug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609ed3b58e7e50f3cca41771dc0df966
https://doi.org/10.1038/s41467-021-24810-5
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10
Development of NanoBRET-Binding Assays for FKBP-Ligand Profiling in Living Cells
Autor: Jürgen M. Kolos, Michael Walz, Thomas M. Geiger, Angela Kuehn, Niklas Gutfreund, Felix Hausch, Monika T. Gnatzy
Publikováno v: Chembiochem
FK506‐binding proteins (FKBPs) are promising targets for a variety of disorders and infectious diseases. High FKBP occupancy is thought to be necessary for ligands to effectively compete with the endogenous intracellular functions of FKBPs. Here, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8264feba8d83d6cf313012490f6da342
https://pubmed.ncbi.nlm.nih.gov/33887102
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