Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Thomas M Chiang"'
Publikováno v:
Drug Target Insights, Vol 3, Pp 67-76 (2008)
Background: AlphaIIb/beta3 (αIIb/β3) complex is an important integrin that is involved in the final step of platelet aggregation. Peptides derived from either αIIb or β3 have demonstrated to have an effect on the activation of the complex and it
Externí odkaz:
https://doaj.org/article/78d4f721a5764f26971a562c76b0bc24
Autor:
Thomas M. Chiang, V. Woo-Rasberry
Publikováno v:
Drug Target Insights, Vol 3, Pp 153-159 (2008)
A chemically synthesized peptide derived from platelet non-integrin collagen receptor has been shown to be an effective agent for inhibiting collagen-induced platelet aggregation and adhesion of washed radiolabeled platelets onto natural matrices and
Externí odkaz:
https://doaj.org/article/57992a6c4f7d469b98b977ad9ed132ac
Autor:
Thomas M. Chiang, V. Woo-Rasberry
Publikováno v:
Drug Target Insights, Vol 3, Iss 1 (2008)
Abstract non disponibile
Externí odkaz:
https://doaj.org/article/bd3f73bdb3f34b3e83dce50edfb97bb0
Publikováno v:
Drug Target Insights, Vol 3, Iss 1 (2008)
Abstract non disponibile
Externí odkaz:
https://doaj.org/article/334a4baa37a947f9915b7300f76885d8
Publikováno v:
Drug Target Insights, Vol 3 (2008)
Background AlphaIIb/beta3 (αIIb/β3) complex is an important integrin that is involved in the final step of platelet aggregation. Peptides derived from either αIIb or β3 have demonstrated to have an effect on the activation of the complex and its
Externí odkaz:
https://doaj.org/article/9feb2a7ef2ae42308489f051227cc5c6
Autor:
Thomas M. Chiang
Publikováno v:
Cardiovascular & Hematological Disorders-Drug Targets. 9:167-171
The function of the platelet collagen receptor, 65-kDa, specific for type I collagen (CI), in eukaryotic cells remains elusive. In order to examine the effect of posttranslational modification of the receptor, we have made a construct, which contains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7bd205429ad32a3b5d58cb95b2f064
https://doi.org/10.2174/187152909789007089
https://doi.org/10.2174/187152909789007089
Publikováno v:
The Open Nitric Oxide Journal. 1:1-4
Nitric oxide (NO), formed through the action of nitric oxide synthase of platelets, which upon exposure to oxy-gen-free radical forming peroxynitrite, could be involved in posttranslational modification of platelet intra- and extracellu-lar proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0422de568f5043c549cd819becf90018
https://doi.org/10.2174/1875042700801010001
https://doi.org/10.2174/1875042700801010001
Publikováno v:
Current Opinion in Rheumatology. 19:574-579
Purpose of review The purpose of this review is to focus attention on platelet contributions, in general, to systemic sclerosis. There have also been recent advances in characterization of the phenotype of platelets in systemic sclerosis which will b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a08ff7f74b255bc62632bff42a589b
https://doi.org/10.1097/bor.0b013e3282eeb3a4
https://doi.org/10.1097/bor.0b013e3282eeb3a4
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1770:1181-1186
We have reported that posttranslational modification of systemic sclerosis patients' platelet phosphoinositide 1,3,4,5 kinase (PI 3-K) and protein kinase B (Akt) altered their enzymatic activities. In the present investigation, we have established a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700ff20de6ed3e0dbfebe2a0ccb59ecc
https://doi.org/10.1016/j.bbagen.2007.04.003
https://doi.org/10.1016/j.bbagen.2007.04.003
Publikováno v:
Cardiovascular & Hematological Disorders-Drug Targets. 7:71-75
Platelet-collagen interaction plays an important role in hemostasis and pathological thrombosis. Upon an injury to the subendothelium of a blood vessel wall, platelets adhere to the denuded substrate, aggregate, and release biological substances. Man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40c2276f160bbcfb81bcb09c4349319
https://doi.org/10.2174/187152907780059056
https://doi.org/10.2174/187152907780059056