Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Thomas M Carlile"'
Autor:
Eris Bame, Hao Tang, Jeremy C Burns, Million Arefayene, Klaus Michelsen, Bin Ma, Isaac Marx, Robin Prince, Allie M Roach, Urjana Poreci, Douglas Donaldson, Patrick Cullen, Fergal Casey, Jing Zhu, Thomas M Carlile, Dipen Sangurdekar, Baohong Zhang, Patrick Trapa, Joseph Santoro, Param Muragan, Alex Pellerin, Stephen Rubino, Davide Gianni, Bekim Bajrami, Xiaomei Peng, Alex Coppell, Katherine Riester, Shibeshih Belachew, Devangi Mehta, Mike Palte, Brian T Hopkins, Matthew Scaramozza, Nathalie Franchimont, Michael Mingueneau
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Objectives Bruton's tyrosine kinase (BTK) plays a non‐redundant signaling role downstream of the B‐cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in myeloid cells. Here, we characterise BIIB09
Externí odkaz:
https://doaj.org/article/960649d0c0f948e3add268a6d5cc0401
Autor:
Thomas M. Carlile, Wendy V. Gilbert, Tristan A Bell, Nicole M. Martinez, Boris Zinshteyn, Amanda Su, Cassandra Schaening
Publikováno v:
Nature chemical biology
Pseudouridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions that affect gene expression. mRNA pseudouridylation was recently discovered as a widespread and conserved phenomenon, but the mechanisms re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee8f0e4787396a87d5d568889d0b676
https://doi.org/10.1038/s41589-019-0353-z
https://doi.org/10.1038/s41589-019-0353-z
Autor:
Christina S. Alves, Chongfeng Xu, Yizhou Zhou, Baohong Zhang, Justin Crisafulli, Eric Marshall, Patrick Cullen, Fergal Casey, Thomas M. Carlile, Chao Sun, Dongdong Lin, Joost Groot
Publikováno v:
Biotechnology journalREFERENCES. 16(8)
In recent years High-Throughput Sequencing (HTS) based methods to detect mutations in biotherapeutic transgene products have become a key quality step deployed during the development of manufacturing cell line clones. Previously we reported on a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7ec4f571cfa5cc295a3e29b246dc19
https://pubmed.ncbi.nlm.nih.gov/34018310
https://pubmed.ncbi.nlm.nih.gov/34018310
SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
Autor:
Melissa Bennion, Justin W. Nicholatos, Andreas Weihofen, Joost Groot, Thomas M. Carlile, Isin Dalkilic-Liddle, Lori Hrdlicka, David T. Tran, Shekhar Dhokai, Warren D. Hirst
Publikováno v:
eNeuro
Here we report the independent discovery and validation of Stearoyl-CoA desaturase (SCD) as a modulator of alpha-synuclein (αSyn) induced pathology and toxicity in cell-based Parkinson’s Disease models (PD). We identified SCD as top altered gene f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113ae30442d1325f7906cb63d467e0e5
https://pubmed.ncbi.nlm.nih.gov/34301719
https://pubmed.ncbi.nlm.nih.gov/34301719
Autor:
Jing Zhu, Xiaomei Peng, Alex Pellerin, Brian T. Hopkins, Dipen Sangurdekar, Michael Mingueneau, Urjana Poreci, Eris Bame, Joseph C Santoro, Prince Robin, Katherine Riester, Mike Palte, Allie M Roach, Klaus Michelsen, Bin Ma, Hao Tang, Million Arefayene, Stephen J Rubino, Devangi Mehta, Fergal Casey, Patrick Cullen, Patrick Trapa, Bekim Bajrami, Thomas M. Carlile, Davide Gianni, Marx Isaac, Douglas Donaldson, Baohong Zhang, Jeremy C. Burns, Param Muragan, Alex Coppell, Shibeshih Belachew, Nathalie Franchimont, Matthew Scaramozza
Publikováno v:
Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Objectives Bruton's tyrosine kinase (BTK) plays a non‐redundant signaling role downstream of the B‐cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in myeloid cells. Here, we characterise BIIB091, a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188cf6754afaaa237193991f00885497
https://doi.org/10.1002/cti2.1295
https://doi.org/10.1002/cti2.1295
Autor:
Alex R. D. Delbridge, Dann Huh, Margot Brickelmaier, Jeremy C. Burns, Chris Roberts, Ravi Challa, Naideline Raymond, Patrick Cullen, Thomas M. Carlile, Katelin A. Ennis, Mei Liu, Chao Sun, Normand E. Allaire, Marianna Foos, Hui-Hsin Tsai, Nathalie Franchimont, Richard M. Ransohoff, Cherie Butts, Michael Mingueneau
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their manifold context-dependent contributions to neuroinflammation are only beginni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55fdea7b0b4f18cf45b9475cf02654b
https://doi.org/10.3389/fncel.2020.592005
https://doi.org/10.3389/fncel.2020.592005
Autor:
Patrick Cullen, Chelsea Parker Harp, Jorge Vera Rebollar, Taylor L. Reynolds, Rebecca Basile, Christie-Ann McCarl, Benjamin A. Smith, Angela Li, Jeremy C. Burns, John Silbereis, Jing Zhu, Ellen Cahir-McFarland, Alex Pellerin, Michael Mingueneau, Stephen J Rubino, Hao Tang, Nathalie Franchimont, Thomas M. Carlile, Baohong Zhang, Jennifer Sybulski, Thomas O. Cameron, Kathryn Pellerin, Richard M. Ransohoff, Luke Jandreski
Publikováno v:
Brain : a journal of neurology. 144(8)
Autoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in peripheral myeloid cells, the pathophysiological significance of autoantibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4631f0f58502257fef331949582c1a
https://pubmed.ncbi.nlm.nih.gov/34382068
https://pubmed.ncbi.nlm.nih.gov/34382068
Autor:
Chao Sun, Justin Crisafulli, Dongdong Lin, Baohong Zhang, Yizhou Zhou, Patrick Cullen, Eric Marshall, Joost Groot, Thomas M. Carlile, Christina S. Alves, Fergal Casey, Chongfeng Xu
In recent years Next-Generation Sequencing (NGS) based methods to detect mutations in biotherapeutic transgene products have become a key quality step deployed during the development of manufacturing cell line clones. Previously we reported on a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::673eb23f17e8240401d01b49c93bb93b
https://doi.org/10.22541/au.160397369.95796795/v1
https://doi.org/10.22541/au.160397369.95796795/v1
Autor:
Zobaida Alsum, Soraya Boucherit, Lluis Quintana-Murci, Peng Zhang, Luigi D. Notarangelo, Joseph A. Church, Daxing Gao, Rabih Halwani, Lazaro Lorenzo, Thomas M. Carlile, Maria F. Rojas-Duran, Ahmed Aziz Bousfiha, Yuval Itan, Laurent Abel, Flore Rozenberg, Fabien G. Lafaille, Wendy V. Gilbert, Jean-Laurent Casanova, Vimel Rattina, Marc Tessier-Lavigne, Lorenz Studer, Trine H. Mogensen, Bastian Zimmer, Benoit Henry, Søren R. Paludan, Shen-Ying Zhang, Franck Rapaport, Gregory A. Smith, Saleh Al-Muhsen, Michael J. Ciancanelli, Gaspard Kerner, Jessica L. McAlpine, Kerry Dobbs, Madalina E. Carter-Timofte, Laura Marques, Oliver Harschnitz, Osefame Ewaleifoh, Mary Hasek, Dominik Paquet, Marc Tardieu, Naima Amenzoui, Yoon Seung Lee, Dylan Kwart
Publikováno v:
Lafaille, F G, Harschnitz, O, Lee, Y S, Zhang, P, Hasek, M L, Kerner, G, Itan, Y, Ewaleifoh, O, Rapaport, F, Carlile, T M, Carter-Timofte, M E, Paquet, D, Dobbs, K, Zimmer, B, Gao, D, Rojas-Duran, M F, Kwart, D, Rattina, V, Ciancanelli, M J, McAlpine, J L, Lorenzo, L, Boucherit, S, Rozenberg, F, Halwani, R, Henry, B, Amenzoui, N, Alsum, Z, Marques, L, Church, J A, Al-Muhsen, S, Tardieu, M, Bousfiha, A A, Paludan, S R, Mogensen, T H, Quintana-Murci, L, Tessier-Lavigne, M, Smith, G A, Notarangelo, L D, Studer, L, Gilbert, W, Abel, L, Casanova, J L & Zhang, S Y 2019, ' Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis ', Nature Medicine, vol. 25, no. 12, pp. 1873-1884 . https://doi.org/10.1038/s41591-019-0672-3
Nature Medicine
Nature Medicine, 2019, 25 (12), pp.1873-1884. ⟨10.1038/s41591-019-0672-3⟩
Nature Medicine, Nature Publishing Group, 2019, 25 (12), pp.1873-1884. ⟨10.1038/s41591-019-0672-3⟩
Nature medicine
Nature Medicine
Nature Medicine, 2019, 25 (12), pp.1873-1884. ⟨10.1038/s41591-019-0672-3⟩
Nature Medicine, Nature Publishing Group, 2019, 25 (12), pp.1873-1884. ⟨10.1038/s41591-019-0672-3⟩
Nature medicine
International audience; Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is typically sporadic. Inborn errors of TLR3- and DBR1-mediated central nervous system cell-intrinsic immunity can account for forebrain and brainstem HSE, respectively. We rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbe9bd2041435e0df6ada9573bd2856
https://pure.au.dk/portal/da/publications/human-snora31-variations-impair-cortical-neuronintrinsic-immunity-to-hsv1-and-underlie-herpes-simplex-encephalitis(81007800-1ad6-46e3-ab81-f589b19898cf).html
https://pure.au.dk/portal/da/publications/human-snora31-variations-impair-cortical-neuronintrinsic-immunity-to-hsv1-and-underlie-herpes-simplex-encephalitis(81007800-1ad6-46e3-ab81-f589b19898cf).html
SUMMARYNon-coding RNAs contain dozens of chemically distinct modifications, of which only a few have been identified in mRNAs. The recent discovery that certain tRNA modifying enzymes also target mRNAs suggests the potential for many additional mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb025ff0f78b18d29ac21763492bc34
https://doi.org/10.1101/271916
https://doi.org/10.1101/271916