Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Thomas M Ashhurst"'
Autor:
Sarah Baird, Caroline L Ashley, Felix Marsh‐Wakefield, Sibel Alca, Thomas M Ashhurst, Angela L Ferguson, Hannah Lukeman, Claudio Counoupas, Jeffrey J Post, Pamela Konecny, Adam Bartlett, Marianne Martinello, Rowena A Bull, Andrew Lloyd, Alice Grey, Owen Hutchings, Umaimainthan Palendira, Warwick J Britton, Megan Steain, James A Triccas
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract Objectives SARS‐CoV‐2 infection causes a spectrum of clinical disease presentation, ranging from asymptomatic to fatal. While neutralising antibody (NAb) responses correlate with protection against symptomatic and severe infection, the c
Externí odkaz:
https://doaj.org/article/b5bb073a3e354d3785e5be131c95ec23
Autor:
So Ri Jung, Thomas M Ashhurst, Phillip K West, Barney Viengkhou, Nicholas J C King, Iain L Campbell, Markus J Hofer
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008525 (2020)
Signal transducers and activators of transcription (STAT) 1 is critical for cellular responses to type I interferons (IFN-Is), with the capacity to determine the outcome of viral infection. We previously showed that while wildtype (WT) mice develop m
Externí odkaz:
https://doaj.org/article/b654269fde574ef9b86fe368546350f6
Autor:
Wuji Zhang, Brendon Y. Chua, Kevin J. Selva, Lukasz Kedzierski, Thomas M. Ashhurst, Ebene R. Haycroft, Suzanne K. Shoffner-Beck, Luca Hensen, David F. Boyd, Fiona James, Effie Mouhtouris, Jason C. Kwong, Kyra Y. L. Chua, George Drewett, Ana Copaescu, Julie E. Dobson, Louise C. Rowntree, Jennifer R. Habel, Lilith F. Allen, Hui-Fern Koay, Jessica A. Neil, Matthew J. Gartner, Christina Y. Lee, Patiyan Andersson, Sadid F. Khan, Luke Blakeway, Jessica Wisniewski, James H. McMahon, Erica E. Vine, Anthony L. Cunningham, Jennifer Audsley, Irani Thevarajan, Torsten Seemann, Norelle L. Sherry, Fatima Amanat, Florian Krammer, Sarah L. Londrigan, Linda M. Wakim, Nicholas J. C. King, Dale I. Godfrey, Laura K. Mackay, Paul G. Thomas, Suellen Nicholson, Kelly B. Arnold, Amy W. Chung, Natasha E. Holmes, Olivia C. Smibert, Jason A. Trubiano, Claire L. Gordon, Thi H. O. Nguyen, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The immune response to SARS-CoV-2 infection is variable but has been linked to prognosis and the development of severe immunopathology. Here the authors assess a range of immune parameters in both peripheral blood and respiratory samples, providing a
Externí odkaz:
https://doaj.org/article/3dbf74c705f948919beba2c6dc7dada4
Autor:
Emina Hayashida, Zheng Lung Ling, Thomas M. Ashhurst, Barney Viengkhou, So Ri Jung, Pattama Songkhunawej, Phillip K. West, Nicholas J. C. King, Markus J. Hofer
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Until the end of the twentieth century, Zika virus (ZIKV) was thought to cause a mostly mild, self-limiting disease in humans. However, as the geographic distribution of ZIKV has shifted, so too has its pathogenicity. Modern-day Z
Externí odkaz:
https://doaj.org/article/448d676df21c488e9a6c3261286bc8dc
Autor:
Anouk von Borstel, Thi HO Nguyen, Louise C Rowntree, Thomas M Ashhurst, Lilith F Allen, Lauren J Howson, Natasha E Holmes, Olivia C Smibert, Jason A Trubiano, Claire L Gordon, Allen C Cheng, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Martin S Davey
Publikováno v:
Immunology & Cell Biology. 101:321-332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d46b550bee8ee411916ea0feb1372025
https://doi.org/10.1111/imcb.12623
https://doi.org/10.1111/imcb.12623
Autor:
Givanna H. Putri, Jonathan Chung, Davis N. Edwards, Felix Marsh‐Wakefield, Irena Koprinska, Suat Dervish, Nicholas J. C. King, Thomas M. Ashhurst, Mark N. Read
Publikováno v:
Cytometry Part A. 103:54-70
Mapping the dynamics of immune cell populations over time or disease-course is key to understanding immunopathogenesis and devising putative interventions. We present TrackSOM, a novel method for delineating cellular populations and tracking their de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb39fbe6bdaa4fdfbc3bc9cceebd8aaf
https://doi.org/10.1002/cyto.a.24668
https://doi.org/10.1002/cyto.a.24668
Autor:
Sarah Baird, Caroline L. Ashley, Felix Marsh-Wakefield, Sibel Alca, Thomas M. Ashhurst, Angela L. Ferguson, Hannah Lukeman, Claudio Counoupas, Jeffrey J. Post, Pamela Konecny, Adam Bartlett, Marianne Martinello, Rowena A. Bull, Andrew Lloyd, Alice Grey, Owen Hutchings, Umaimainthan Palendira, Warwick J. Britton, Megan Steain, James A. Triccas
Background and objectivesSARS-CoV-2 infection causes a spectrum of clinical disease presentation, ranging from asymptomatic to fatal. While neutralising antibody (NAb) responses correlate with protection against symptomatic and severe infection, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788fb1b4440fa118fd3e487dbfd66b68
https://doi.org/10.1101/2023.02.17.23286059
https://doi.org/10.1101/2023.02.17.23286059
Autor:
Martin Prlic, Natalie Stanley, Thomas Liechti, Thomas M. Ashhurst, Florian Mair, Sofie Van Gassen, Lukas M. Weber
Publikováno v:
Nature Immunology. 22:1190-1197
High-dimensional cytometry experiments measuring 20–50 cellular markers have become routine in many laboratories. The increased complexity of these datasets requires added rigor during the experimental planning and the subsequent manual and computa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de36e89e86592d7a4bdbcaf9736e8a18
https://doi.org/10.1038/s41590-021-01006-z
https://doi.org/10.1038/s41590-021-01006-z
Autor:
Iain L. Campbell, Rachel Louise Terry, Thomas M. Ashhurst, Claire L. Wishart, Nicholas J. C. King, Markus J. Hofer, Alanna Gabrielle Spiteri
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundDifferentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘microglia-like’ phenotype. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae49962fb4459e1edf85045dbe644330
https://doaj.org/article/ebf58f4e1d3f4998b8f08e4ddf92213b
https://doaj.org/article/ebf58f4e1d3f4998b8f08e4ddf92213b
Autor:
Nicholas J. C. King, Diana Shinko, Alanna Gabrielle Spiteri, Thomas M. Ashhurst, Felix Marsh-Wakefield, Adrian L. Smith, Mark Read, Givanna H. Putri
Publikováno v:
Cytometry Part A. 101:237-253
As the size and complexity of high-dimensional (HD) cytometry data continue to expand, comprehensive, scalable, and methodical computational analysis approaches are essential. Yet, contemporary clustering and dimensionality reduction tools alone are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83960d837b1976f578b862c4061c5705
https://doi.org/10.1002/cyto.a.24350
https://doi.org/10.1002/cyto.a.24350