Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Thomas Müller-Späth"'
Autor:
Ismaele Fioretti, Thomas Müller‐Späth, Richard Weldon, Sebastian Vogg, Massimo Morbidelli, Mattia Sponchioni
Publikováno v:
Biotechnology and bioengineering. 119(7)
Oligonucleotides (ONs) are breaking through in the biopharmaceutical industry as a promising class of biotherapeutics. The main success of these molecules is due to their peculiar way of acting in the cellular process, regulating the gene expression
Autor:
Richard Weldon, Thomas Müller-Späth
Publikováno v:
Journal of chromatography. A. 1667
N-Rich is a twin-column chromatography process that enriches target compounds relative to other components in a mixture, thereby facilitating their isolation and characterization. This study demonstrates the performance of N-Rich for isolation of Ang
Publikováno v:
Journal of chromatography. A. 1663
Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) is a continuous chromatography technique used to maximize purification yields compared to traditional batch purification methods. Here we apply MCSGP for the reversed phase purification
Publikováno v:
Journal of Chromatography B. 1209:123439
N-Rich is a twin-column continuous chromatography technology well suited for small-scale isolation and the enrichment of product related impurities. For the first time, N-Rich was used for impurity isolation from a double-stranded RNA (dsRNA) therape
Autor:
Simona Jusyte, Zheng Jian Li, Xuankuo Xu, Thomas Müller-Späth, Sanchayita Ghose, Srinivas Chollangi, James Angelo
Publikováno v:
Biotechnology and Bioengineering. 116:2275-2284
Multicolumn capture chromatography is gaining increased attention lately due to the significant economic and process advantages it offers compared with traditional batch mode chromatography. However, for wide adoption of this technology in clinical a
Publikováno v:
Current Opinion in Chemical Engineering. 22:138-144
Continuous processing of biopharmaceuticals has seen increased interest in recent years due to more competition in the market as well as broader pipelines asking for more flexible and therefore intensified processes. For downstream processing, chroma
Autor:
Sanchayita Ghose, Xuankuo Xu, Zheng Jian Li, James Angelo, Massimo Morbidelli, Thomas Müller-Späth, Daniel Baur, Srinivas Chollangi
Publikováno v:
Biotechnology and Bioengineering. 116:87-98
In this study we introduce three process characterization approaches toward validation of continuous twin-column capture chromatography (CaptureSMB), referred to as "standard," "model assisted," and "hybrid." They are all based on a traditional risk-
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(9)
Multi-column capture chromatography (MCC) has gained increased attention lately due to the significant economic and process-related advantages it offers compared to traditional batch mode chromatography. However, for wide adoption of this technology
Autor:
Nicolò Manfredini, Martina Catani, Richard Weldon, Mattia Sponchioni, Chiara De Luca, Elena Marchesi, Massimo Morbidelli, Alberto Cavazzini, Daniela Perrone, Thomas Müller-Späth, João Medeiros Garcia Alcântara
Oligonucleotides (ONs) are gaining increasing importance as a promising novel class of biopharmaceuticals. Thanks to their fundamental role in gene regulation, they can be used to develop custom-made drugs (also called N-to-1) able to act on the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2832e3036381a343209840f5adb8b0c
http://hdl.handle.net/11311/1144628
http://hdl.handle.net/11311/1144628
Autor:
Massimo Morbidelli, Nilay Shah, Justin Katz, Maria M. Papathanasiou, Efstratios N. Pistikopoulos, Thomas Müller-Späth, Baris Burnak
This work demonstrates the development of a novel control scheme for small-scale chromatographic systems, using the integrated outlet concentrations as tracked outputs. The controller is designed based on the principles of multi-parametric programmin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6e9f29fac7ef257cc375721f436f7c9
https://doi.org/10.1016/b978-0-12-818597-1.50043-6
https://doi.org/10.1016/b978-0-12-818597-1.50043-6