Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Thomas Müller-Späth"'
Autor:
Ismaele Fioretti, Thomas Müller‐Späth, Richard Weldon, Sebastian Vogg, Massimo Morbidelli, Mattia Sponchioni
Publikováno v:
Biotechnology and bioengineering. 119(7)
Oligonucleotides (ONs) are breaking through in the biopharmaceutical industry as a promising class of biotherapeutics. The main success of these molecules is due to their peculiar way of acting in the cellular process, regulating the gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16ad28e05f04e16ec270dc465045e47
https://pubmed.ncbi.nlm.nih.gov/35338661
https://pubmed.ncbi.nlm.nih.gov/35338661
Autor:
Richard Weldon, Thomas Müller-Späth
Publikováno v:
Journal of chromatography. A. 1667
N-Rich is a twin-column chromatography process that enriches target compounds relative to other components in a mixture, thereby facilitating their isolation and characterization. This study demonstrates the performance of N-Rich for isolation of Ang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09422bb09800c71c847e065d54b3d720
https://pubmed.ncbi.nlm.nih.gov/35219108
https://pubmed.ncbi.nlm.nih.gov/35219108
Publikováno v:
Journal of chromatography. A. 1663
Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) is a continuous chromatography technique used to maximize purification yields compared to traditional batch purification methods. Here we apply MCSGP for the reversed phase purification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f38310dbb20f9d539a44a87dfbb4da6
https://pubmed.ncbi.nlm.nih.gov/34968958
https://pubmed.ncbi.nlm.nih.gov/34968958
Publikováno v:
Journal of Chromatography B. 1209:123439
N-Rich is a twin-column continuous chromatography technology well suited for small-scale isolation and the enrichment of product related impurities. For the first time, N-Rich was used for impurity isolation from a double-stranded RNA (dsRNA) therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b890c74632905c572bce6ea87ef67d
https://doi.org/10.1016/j.jchromb.2022.123439
https://doi.org/10.1016/j.jchromb.2022.123439
Autor:
Simona Jusyte, Zheng Jian Li, Xuankuo Xu, Thomas Müller-Späth, Sanchayita Ghose, Srinivas Chollangi, James Angelo
Publikováno v:
Biotechnology and Bioengineering. 116:2275-2284
Multicolumn capture chromatography is gaining increased attention lately due to the significant economic and process advantages it offers compared with traditional batch mode chromatography. However, for wide adoption of this technology in clinical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11b9537293d9818270d18dc371a8beb
https://doi.org/10.1002/bit.27012
https://doi.org/10.1002/bit.27012
Publikováno v:
Current Opinion in Chemical Engineering. 22:138-144
Continuous processing of biopharmaceuticals has seen increased interest in recent years due to more competition in the market as well as broader pipelines asking for more flexible and therefore intensified processes. For downstream processing, chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1de427ab023844548c73601eef6235a9
https://doi.org/10.1016/j.coche.2018.09.001
https://doi.org/10.1016/j.coche.2018.09.001
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(9)
Multi-column capture chromatography (MCC) has gained increased attention lately due to the significant economic and process-related advantages it offers compared to traditional batch mode chromatography. However, for wide adoption of this technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c898605b72412ad8349591652fd489
https://pubmed.ncbi.nlm.nih.gov/33421115
https://pubmed.ncbi.nlm.nih.gov/33421115
Autor:
Nicolò Manfredini, Martina Catani, Richard Weldon, Mattia Sponchioni, Chiara De Luca, Elena Marchesi, Massimo Morbidelli, Alberto Cavazzini, Daniela Perrone, Thomas Müller-Späth, João Medeiros Garcia Alcântara
Oligonucleotides (ONs) are gaining increasing importance as a promising novel class of biopharmaceuticals. Thanks to their fundamental role in gene regulation, they can be used to develop custom-made drugs (also called N-to-1) able to act on the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2832e3036381a343209840f5adb8b0c
http://hdl.handle.net/11311/1144628
http://hdl.handle.net/11311/1144628
Autor:
Paolo Arosio, Marta Owczarz, Thomas Müller-Späth, Paola Rognoni, Marten Beeg, Hua Wu, Mario Salmona, Massimo Morbidelli
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33372 (2012)
Excessive production of monoclonal light chains due to multiple myeloma can induce aggregation-related disorders, such as light chain amyloidosis (AL) and light chain deposition diseases (LCDD). In this work, we produce a non-amyloidogenic IgE λ lig
Externí odkaz:
https://doaj.org/article/36f19e9b77474c99ad1152a1deaa1025
Autor:
Sanchayita Ghose, Xuankuo Xu, Zheng Jian Li, James Angelo, Massimo Morbidelli, Thomas Müller-Späth, Daniel Baur, Srinivas Chollangi
Publikováno v:
Biotechnology and Bioengineering. 116:87-98
In this study we introduce three process characterization approaches toward validation of continuous twin-column capture chromatography (CaptureSMB), referred to as "standard," "model assisted," and "hybrid." They are all based on a traditional risk-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a956aab337f784185c7ae0ef4e99c60a
https://doi.org/10.1002/bit.26849
https://doi.org/10.1002/bit.26849