Establishing the pig as a large animal model for vaccine development against human cancer

Autor: Nana Haahr Overgaard, Thomas Mørch Frøsig, Simon eWelner, Michael eRasmussen, Mette eIlsøe, Maria Rathmann Sørensen, Mads Hald Andersen, Søren eBuus, Gregers eJungersen

Publikováno v: Frontiers in Genetics, Vol 6 (2015)

Immunotherapy has increased overall survival of metastatic cancer patients, and cancer antigens are promising vaccine targets. To fulfill the promise, appropriate tailoring of the vaccine formulations to mount in vivo cytotoxic T cell (CTL) responses

Externí odkaz: https://doaj.org/article/7edf0b30aae84d7abea3ce2916f84b7f

Supplementary Figure 2 from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients

Autor: Mads Hald Andersen, Inge Marie Svane, Tobias Wirenfeldt Klausen, Stine Kiaer Larsen, Thomas Mørch Frøsig, Marco Donia, Özcan Met, Gitte Holmen Andersen, Shamaila Munir

PDF file - 36K, Blocking surface PD-1/PD-L1 did not effect the cytotoxic capacity of PD-1 negative, PD-L1 specific T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4952a4f357046225dd84e165de2e26f3
https://doi.org/10.1158/0008-5472.22400229.v1

Supplementary Figure Legend from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients

Autor: Mads Hald Andersen, Inge Marie Svane, Tobias Wirenfeldt Klausen, Stine Kiaer Larsen, Thomas Mørch Frøsig, Marco Donia, Özcan Met, Gitte Holmen Andersen, Shamaila Munir

PDF file - 88K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9d3436285faca60833a7ee55fef883
https://doi.org/10.1158/0008-5472.22400223.v1

Design and validation of conditional ligands for HLA-B*08:01, HLA-B*15:01, HLA-B*35:01, and HLA-B*44:05

Autor: Per thor Straten, Mirjam H.M. Heemskerk, Tina Seremet, Thomas Mørch Frøsig, Rikke Birgitte Lyngaa, Jiawei Yap, Gijsbert M. Grotenbreg, Inge Marie Svane, Sine Reker Hadrup

Publikováno v: Cytometry Part A. 87:967-975

We designed conditional ligands restricted to HLA-B*08:01, -B*35:01, and -B*44:05 and proved the use of a conditional ligand previously designed for HLA-B*15:02 together with HLA-B*15:01. Furthermore, we compared the detection capabilities of specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67568015db412e4bbf0c42e422bc82cf
https://doi.org/10.1002/cyto.a.22689

Low antigen dose formulated in CAF09 adjuvant Favours a cytotoxic T-cell response following intraperitoneal immunization in Göttingen minipigs

Autor: Gregers Jungersen, Jeanne Toft Jakobsen, Søren Buus, Mads Hald Andersen, Nana Haahr Overgaard, Thomas Mørch Frøsig

Publikováno v: Overgaard, N H, Frøsig, T M, Jakobsen, J T, Buus, S, Andersen, M H & Jungersen, G 2017, ' Low antigen dose formulated in CAF09 adjuvant Favours a cytotoxic T-cell response following intraperitoneal immunization in Göttingen minipigs ', Vaccine, vol. 35, no. 42, pp. 5629-5636 . https://doi.org/10.1016/j.vaccine.2017.08.057

The relationship between the antigen dose and the quality of an immune response generated upon immunization is poorly understood. However, findings show that the immune system is indeed influenced by the antigen dose; hence underlining the importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482afa7ac878dc6b49b3c1ef4a750e16
https://curis.ku.dk/portal/da/publications/low-antigen-dose-formulated-in-caf09-adjuvant-favours-a-cytotoxic-tcell-response-following-intraperitoneal-immunization-in-goettingen-minipigs(46b8c56a-4f23-46c5-b7d9-152cce4a32ff).html