Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Thomas M, Kündig"'
Autor:
Ásdís Hjálmsdóttir, Fabio Hasler, Ying Waeckerle-Men, Agathe Duda, María Pilar López-Deber, Maria Pihlgren, Marija Vukicevic, Thomas M. Kündig, Pål Johansen
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Vaccines generally require T lymphocytes for B-cell activation and immunoglobulin class switching in response to peptide or protein antigens. In the absence of T cells, limited IgG class switch takes place, germinal centers are short-lived,
Externí odkaz:
https://doaj.org/article/277c02fabbda4e7584e0111980478e83
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
ObjectivesPeanut allergy is an IgE-mediated food allergy that is associated with asthma in certain patients. With increasing prevalence, its great impact on the quality of life, and a lack of treatment options, the need for new therapy options is a g
Externí odkaz:
https://doaj.org/article/a09e238f53c84bceb7d1b7c072b22888
Autor:
Shahab Mamaghani, Rocco Roberto Penna, Julia Frei, Conrad Wyss, Mark Mellett, Thomas Look, Tobias Weiss, Emmanuella Guenova, Thomas M. Kündig, Severin Lauchli, Steve Pascolo
Publikováno v:
Cells, Vol 13, Iss 15, p 1242 (2024)
Synthetic mRNA produced by in vitro transcription (ivt mRNA) is the active pharmaceutical ingredient of approved anti-COVID-19 vaccines and of many drugs under development. Such synthetic mRNA typically contains several hundred bases of non-coding
Externí odkaz:
https://doaj.org/article/5431fc445dd74b9097329e29d690d397
Autor:
Natalia Teresa Jarzebska, Marina Tusup, Julia Frei, Tobias Weiss, Tim Holzinger, Mark Mellett, Mustafa Diken, Simon Bredl, Michael Weller, Roberto F. Speck, Thomas M. Kündig, Ugur Sahin, Steve Pascolo
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Nanoparticles of different sizes formulated with unmodified RNA and Protamine differentially engage Toll-like Receptors (TLRs) and activate innate immune responses in vitro. Here, we report that similar differential immunostimulation that depends on
Externí odkaz:
https://doaj.org/article/636d2ae4aff3428891160e5ede030946
Autor:
Lara Šošić, Marta Paolucci, Agathe Duda, Fabio Hasler, Senta M. Walton, Thomas M. Kündig, Pål Johansen
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Introduction Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), substantial effort has been made to gain knowledge about the immunity elicited by infection or vaccination. Methods We studied the kinetics
Externí odkaz:
https://doaj.org/article/f917de0087e14f71a1de856b676ca37b
Autor:
Alexandra Chabot, Gabriela Senti, Iris Erdmann, Bettina M. Prinz, Brunello Wüthrich, Lara Šošić, Thomas M. Kündig, Pål Johansen
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
BackgroundSubcutaneous venom immunotherapy (VIT) represents an effective treatment against bee venom allergy. However, it involves long treatment times, high costs, and the risk of adverse events (AEs). Shorter, safer, and cheaper treatment options a
Externí odkaz:
https://doaj.org/article/60f0105985564c1a941a0abd78ba3b93
Autor:
Natalia Teresa Jarzebska, Severin Lauchli, Christoph Iselin, Lars E French, Pal Johansen, Emmanuella Guenova, Thomas M Kündig, Steve Pascolo
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 1231-1235 (2020)
Protamine is a natural cationic peptide mixture used as a drug for the neutralization of heparin and in formulations of slow-release insulin. In addition, Protamine can be used for the stabilization and delivery of nucleic acids (antisense, small int
Externí odkaz:
https://doaj.org/article/b443ee8aff8746f7aab3b115e8c81a38
Autor:
Ying Waeckerle-Men, Zuzanna K. Kotkowska, Géraldine Bono, Agathe Duda, Isabel Kolm, Eleni M. Varypataki, Beat Amstutz, Michael Meuli, Anders Høgset, Thomas M. Kündig, Cornelia Halin, Peter Sander, Pål Johansen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Conventional vaccines are very efficient in the prevention of bacterial infections caused by extracellular pathogens due to effective stimulation of pathogen-specific antibodies. In contrast, considering that intracellular surveillance by antibodies
Externí odkaz:
https://doaj.org/article/0bcefb35bffe44a18ecac599fa99313f
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100824- (2021)
Summary: For a cytopathic virus such as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the neutralization capacity of serum from convalescent or vaccinated persons or of therapeutic antibodies can be tested on adherent cell cultur
Externí odkaz:
https://doaj.org/article/9ce0322952ee43a49fdb7208a3df74bb
Autor:
Pieter-Jan De Kam, PhD, Matthias F. Kramer, MD, Mohamed H. Shamji, PhD, Kemi Oluwayi, MD, Matthew D. Heath, PhD, Erika Jensen-Jarolim, MD, Markus H. Berger, MD, Uwe E. Berger, MBA, Anke Graessel, PhD, Fiona Sellwood, Stefan Zielen, MD, Christian Vogelberg, MD, Petra Zieglmayer, MD, Ralph Mösges, MD, PhD, Ludger Klimek, MD, PhD, Lawrence M. DuBuske, MD, Wayne G. Shreffler, MD, PhD, Jonathan A. Bernstein, MD, Thomas M. Kündig, MD, Murray A. Skinner, PhD
Publikováno v:
World Allergy Organization Journal, Vol 14, Iss 9, Pp 100578- (2021)
The concept of treatment of an allergy with the offending allergen was introduced more than a century ago. Allergen immunotherapy (AIT) is the only disease modifying treatment of allergic diseases caused by inhalational allergens and insect venoms. D
Externí odkaz:
https://doaj.org/article/bbc85a2ec6b54c71b9f26a7fc41ee8c3