Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Thomas M, Aune"'
Autor:
Anna E. Patrick, Kayla Shoaff, Tashawna Esmond, David M. Patrick, David K. Flaherty, T Brent Graham, Philip S. Crooke, Susan Thompson, Thomas M. Aune
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In juvenile idiopathic arthritis (JIA) inflammatory T cells and their produced cytokines are drug targets and play a role in disease pathogenesis. Despite their clinical importance, the sources and types of inflammatory T cells involved remain unclea
Externí odkaz:
https://doaj.org/article/dc42e2db61734440a0adf1c18b6b5635
Autor:
Takumi Itoh, Ryo Hatano, Yoshiya Horimoto, Taketo Yamada, Dan Song, Haruna Otsuka, Yuki Shirakawa, Shuji Mastuoka, Noriaki Iwao, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Ko Okumura, Chikao Morimoto, Kei Ohnuma
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-17 (2021)
Abstract Triple-negative breast cancer (TNBC) has a poor prognosis compared to other breast cancer subtypes. Although epidermal growth factor receptor (EGFR) is overexpressed in TNBC, clinical trials with EGFR inhibitors including tyrosine kinase inh
Externí odkaz:
https://doaj.org/article/56e668697c254208a1ec8f6af7dc9a5a
Publikováno v:
Current Research in Immunology, Vol 2, Iss , Pp 52-59 (2021)
Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-stranded RNAs (ds
Externí odkaz:
https://doaj.org/article/99bdb7239733469e9ba3ce5531eb37e3
Publikováno v:
BioTechniques, Vol 69, Iss 4, Pp 281-288 (2020)
We present a method to synthesize mRNAs from synthetic DNA templates that produce biologically active proteins. To illustrate utility, we constructed five unique synthetic DNA templates, produced mRNAs and demonstrated biologic activity of their tran
Externí odkaz:
https://doaj.org/article/6cbccd87a45f401fa875c41b0b7e5d4a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alu retrotransposons belong to the class of short interspersed nuclear elements (SINEs). Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with
Externí odkaz:
https://doaj.org/article/cba9c00726d949239c293db01b634cd7
Autor:
Anna E. Patrick, Wei Wang, Elly Brokamp, Thomas Brent Graham, Thomas M. Aune, Jessica B. Duis
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background GATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. We present the
Externí odkaz:
https://doaj.org/article/7a1840121ed14fb3a819863badfc2ebc
Autor:
Ryo Hatano, Takumi Itoh, Haruna Otsuka, Harumi Saeki, Ayako Yamamoto, Dan Song, Yuki Shirakawa, Satoshi Iyama, Tsutomu Sato, Noriaki Iwao, Norihiro Harada, Thomas M. Aune, Nam H. Dang, Yutaro Kaneko, Taketo Yamada, Chikao Morimoto, Kei Ohnuma
Publikováno v:
American Journal of Transplantation. 22:2804-2820
IL-26 is a Th17 cytokine, with its gene being absent in rodents. To characterize the in vivo immunological effects of IL-26 in chronic systemic inflammation, we used human IL26 transgenic (hIL-26Tg) mice and human umbilical cord blood mononuclear cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a071c234f77d496bca2fa1e08870f9
https://doi.org/10.1111/ajt.17178
https://doi.org/10.1111/ajt.17178
Autor:
Thomas M. Aune
Publikováno v:
Clinical Immunology ISBN: 9780702081651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe8fc4cb2b6db0ce5f8a71b6353b72b
https://doi.org/10.1016/b978-0-7020-8165-1.00019-8
https://doi.org/10.1016/b978-0-7020-8165-1.00019-8
Autor:
Hunter R. Gibbons, Guzel Shaginurova, Laura C. Kim, Nathaniel Chapman, Charles F. Spurlock, Thomas M. Aune
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Long non-coding RNAs (lncRNAs) possess a diverse array of regulatory functions including activation and silencing of gene transcription, regulation of splicing, and coordinating epigenetic modifications. GATA3-AS1 is a divergent lncRNA gene neighbori
Externí odkaz:
https://doaj.org/article/874be4a53b014fdb999ac9e38cdc0f31
Longitudinal changes in the expression of IL-33 and IL-33 regulated genes in relapsing remitting MS.
Autor:
Subramaniam Sriram, Guzel Shaginurova, John T Tossberg, Chandramohan Natarajan, Charles F Spurlock, Thomas M Aune
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208755 (2018)
OBJECTIVE:We tested the hypothesis that the expression of IL-33 in MS is dynamic and is likely to reflect the clinical and radiological changes during the course of RRMS. METHODS:MS with either clinical or radiological relapses were recruited for the
Externí odkaz:
https://doaj.org/article/3a47eaca5fc64df3b9373cd16f25b717