Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Thomas Luft"'
Autor:
Xiang Zhou, Patrick Costello, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Max Topp, Hartmut Goldschmidt, Hermann Einsele, Nikhil C Munshi, Marc S Raab, Joseph Kauer, Thomas Hielscher, Niels Weinhold, Mirco J Friedrich, Sandra Sauer, Leo Rasche, Thomas Luft, Jan H Frenking, Vivien Wagner, Elias K Mai, Christian S Michel, Marina Hajiyianni, Iris Breitkreutz, Omar Nadeem, Adam S Sperling
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Background Chimeric antigen receptor (CAR) T-cell therapy has demonstrated significant benefits in the treatment of relapsed/refractory multiple myeloma (RRMM). However, these outcomes can be compromised by severe complications, including cytokine re
Externí odkaz:
https://doaj.org/article/8940433ced884d68a993840e8bd1f4cb
Autor:
Rea Kuehl, Jule Feyer, Matthias Limbach, Antonia Pahl, Friederike Stoelzel, Heidrun Beck, Annika Wegner, Friederike Rosenberger, Peter Dreger, Thomas Luft, Joachim Wiskemann
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Physical capacity prior allogeneic stem cell transplantation (allo-HCT) has been shown as a relevant prognostic factor for survival after transplant. Therefore, we evaluated feasibility and preliminary efficacy of a high-intensity interval t
Externí odkaz:
https://doaj.org/article/113858f068e74dfe986969d8de6ec0ad
Autor:
Evren Bayraktar, Theresa Graf, Francis A. Ayuk, Gernot Beutel, Olaf Penack, Thomas Luft, Nicole Brueder, Gastone Castellani, H. Christian Reinhardt, Nicolaus Kröger, Dietrich W. Beelen, Amin T. Turki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Despite advances in allogeneic hematopoietic cell transplantation, acute graft-versus-host disease (aGVHD) remains its leading complication, yet with heterogeneous outcomes. Here, we analyzed aGVHD phenotypes and clinical classifications in
Externí odkaz:
https://doaj.org/article/bb726bc78632416a8d9d063e67a7b93f
Autor:
Axel Benner, Peter Dreger, Grzegorz W Basak, Christian Koenecke, Olaf Penack, Christophe Peczynski, Lucia López Corral, Ivan Moiseev, Hélène Schoemans, Zinaida Peric, Thomas Luft, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background We previously reported that the “Endothelial Activation and Stress Index” (EASIX; ((creatinine×lactate dehydrogenase)÷thrombocytes)) measured before start of conditioning predicts mortality after allogeneic hematopoietic stem cell tr
Externí odkaz:
https://doaj.org/article/60017a9b556c4c1eaccc5b562a3da144
Autor:
Kavita Raj, Dirk-Jan Eikema, Vipul Sheth, Linda Koster, Liesbeth C. de Wreede, Didier Blaise, Carmela Di Grazia, Yener Koc, Victoria Potter, Patrice Chevallier, Lucia Lopez- Corral, Depei Wu, Stephan Mielke, Johan Maertens, Ellen Meijer, Anne Huynh, Jakob Passweg, Thomas Luft, Jose Antonio Pérez-Simón, Fabio Ciceri, Agnieszka Piekarska, G. Hayri Ozsan, Nicolaus Kröger, Marie Robin, Ibrahim Yakoub-Agha
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 9, Pp 1-10 (2022)
Abstract Myelodysplastic syndromes (MDS) are the second common indication for an Allo-HCT. We compared the outcomes of 1414 matched sibling (MSD) with 415 haplo-identical donors (HD) transplanted with post-transplant cyclophosphamide (PTCy) as GVHD p
Externí odkaz:
https://doaj.org/article/f44eda11500640cfb503ad8274936bf1
Autor:
Janina Bujan Rivera, Rea Kühl, Ulrike Zech, Anne Hendricks, Thomas Luft, Peter Dreger, Birgit Friedmann-Bette, Theresa-Maria Betz, Joachim Wiskemann
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Graft-versus-host disease (GvHD) remains a major complication and limitation to successful allogeneic hematopoietic stem cell transplantation. Treatment of GvHD is challenging due to its heterogeneous nature of presentation, with
Externí odkaz:
https://doaj.org/article/01bed7b3e18e4af79555303eb0ed4e4f
Autor:
Hao Dai, Sivaramakrishna P. Rachakonda, Olaf Penack, Igor W. Blau, Olga Blau, Aleksandar Radujkovic, Carsten Müller-Tidow, Peter Dreger, Rajiv Kumar, Thomas Luft
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 2, Pp 1-12 (2021)
Abstract Chronic graft-versus-host disease (cGVHD) is a major cause of mortality and morbidity after allogeneic stem cell transplantation (alloSCT). The individual risk of severe cGVHD remains difficult to predict and may involve CXCR3 ligands. This
Externí odkaz:
https://doaj.org/article/971e0d0bb95d481495b6e90192e86eeb
Autor:
Felix Korell, Olaf Penack, Mike Mattie, Nicholas Schreck, Axel Benner, Julia Krzykalla, Zixing Wang, Michael Schmitt, Lars Bullinger, Carsten Müller-Tidow, Peter Dreger, Thomas Luft
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundEndothelial dysfunction is associated with two main complications of chimeric antigen receptor T (CAR-T) cell therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). This study evaluates
Externí odkaz:
https://doaj.org/article/5af2f532a2474b2d9fbca87325e4c565
Autor:
Aleksandar Radujkovic, Lambros Kordelas, Hao Dai, David Schult, Joshua Majer-Lauterbach, Dietrich Beelen, Carsten Müller-Tidow, Peter Dreger, Thomas Luft
Publikováno v:
EBioMedicine, Vol 49, Iss , Pp 202-212 (2019)
Background: Interleukin-18 (IL-18) is involved in endothelial activation and dysfunction, and in the pathogenesis and severity of acute graft-versus-host disease (aGVHD). Its relevance for patient outcome after allogeneic stem cell transplantation (a
Externí odkaz:
https://doaj.org/article/9513b51f5e604e0eb751e00676a90e1d
Autor:
Laura Orsatti, Thomas Stiehl, Katharina Dischinger, Roberto Speziale, Pamela Di Pasquale, Edith Monteagudo, Carsten Müller-Tidow, Aleksandar Radujkovic, Peter Dreger, Thomas Luft
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100409- (2021)
Summary: Fibrosing chronic graft-versus-host disease (cGVHD) is a debilitating complication of allogeneic stem cell transplantation (alloSCT). A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influen
Externí odkaz:
https://doaj.org/article/dd8f78204321413ba3f5a727df27aac9