Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Thomas Lindenstrom"'
Autor:
Joshua S. Woodworth, Vanessa Contreras, Dennis Christensen, Thibaut Naninck, Nidhal Kahlaoui, Anne-Sophie Gallouët, Sébastien Langlois, Emma Burban, Candie Joly, Wesley Gros, Nathalie Dereuddre-Bosquet, Julie Morin, Ming Liu Olsen, Ida Rosenkrands, Ann-Kathrin Stein, Grith Krøyer Wood, Frank Follmann, Thomas Lindenstrøm, Tu Hu, Roger Le Grand, Gabriel Kristian Pedersen, Rasmus Mortensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Development of new vaccines tailored for difficult-to-target diseases is hampered by a lack of diverse adjuvants for human use, and none of the currently available adjuvants induce Th17 cells. Here, we develop a liposomal adjuvant, CAF®10b,
Externí odkaz:
https://doaj.org/article/247707a325064a6ea6e1237d4d196721
A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG
Autor:
Karin Dijkman, Thomas Lindenstrøm, Ida Rosenkrands, Rikke Søe, Joshua S. Woodworth, Cecilia S. Lindestam Arlehamn, Rasmus Mortensen
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract The only licensed tuberculosis (TB) vaccine, Bacillus Calmette Guerin (BCG), fails to reliably protect adolescents and adults from pulmonary TB, resulting in ~1.6 million deaths annually. Protein subunit vaccines have shown promise against T
Externí odkaz:
https://doaj.org/article/e5bea802532e4b85bb0bd072def421f9
Autor:
Fatima A. H. Al-Jaberi, Cornelia Geisler Crone, Thomas Lindenstrøm, Nicolai Skovbjerg Arildsen, Emilia Sæderup Lindeløv, Louise Aagaard, Eva Gravesen, Rasmus Mortensen, Aase Bengaard Andersen, Klaus Olgaard, Jessica Xin Hjaltelin, Søren Brunak, Charlotte Menné Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tuberculosis (TB) presents a serious health problem with approximately a quarter of the world’s population infected with Mycobacterium tuberculosis (M. tuberculosis) in an asymptomatic latent state of which 5–10% develops active TB at some point
Externí odkaz:
https://doaj.org/article/fbee91fde87b4df0a8a226a8e14e1831
Autor:
Stefan H. E. Kaufmann, Hazel M. Dockrell, Nick Drager, Mei Mei Ho, Helen McShane, Olivier Neyrolles, Tom H. M. Ottenhoff, Brij Patel, Danielle Roordink, François Spertini, Steffen Stenger, Jelle Thole, Frank A. W. Verreck, Ann Williams, TBVAC2020 Consortium, Warwick Britton, Jamie Triccas, Claudio Counoupas, Johan Grooten, Marie-Ange Demoitie, Marta Romano, Francoise Mascart, Peter Andersen, Claus Aagaard, Dennis Christensen, Morten Ruhwald, Thomas Lindenstrom, Pierre Charneau, Christophe Guilhot, Antonio Peixoto, Martine Gilleron, Camille Locht, Roland Brosch, Genevieve Inchauspe, Stephane Leung Theung Long, Stefan Kaufmann, January Weiner, Jeroen Maertzdorf, Natalie Neuwenhuizen, Max Bastian, Nadia Caccamo, Delia Goletti, Roberto Nisini, Sung Jae Shin, Hyejon Lee, Alex Sigal, Thomas Scriba, Gerhard Walzl, Andre Loxton, Robert Wilkinson, Pere-Joan Cardona, Cris Vilaplana, Carlos Martin, Dessi Marinova, Nacho Aguilo, Ruedi Aebersold, Etienne Caron, Daniel Pinschewer, Gennaro De Libero, Claire Anne Siegrist, Nicolas Collin, Christophe Barnier-Quer, Peter Sander, Frank Verreck, Tom Ottenhoff, Simone Joosten, Krista van Meijgaarden, Mariateresa Coppola, Annemieke Geluk, Yvonne Perrie, Marc Baird, Michael Levin, Hazel Dockrell, Steven Smith, Helen Fletcher, Gregory Bancroft, Ann Rawkins, Simon Clark, Iman Satti, Elena Stylianou, Martin Vordermeier, Philip Hogarth
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The p
Externí odkaz:
https://doaj.org/article/c7965df9c6da40b7adb41882e3834949
Autor:
Joshua S. Woodworth, Helena Strand Clemmensen, Hannah Battey, Karin Dijkman, Thomas Lindenstrøm, Raquel Salvador Laureano, Randy Taplitz, Jeffrey Morgan, Claus Aagaard, Ida Rosenkrands, Cecilia S. Lindestam Arlehamn, Peter Andersen, Rasmus Mortensen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Tuberculosis (TB) subunit vaccines have been investigated as boosters for BCG-induced immunity. Here, the authors design a TB subunit vaccine that doesn't share antigens with BCG and show that co-administration of the two vaccines broadens the T cell
Externí odkaz:
https://doaj.org/article/e8cde506edf04ab4beac2a4d5130dcb7
Autor:
Thomas Lindenstrøm, Albanus Moguche, Mie Damborg, Else Marie Agger, Kevin Urdahl, Peter Andersen
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 27-39 (2018)
Despite inducing strong T cell responses, Mycobacterium tuberculosis (Mtb) infection fails to elicit protective immune memory. As such latently infected or successfully treated Tuberculosis (TB) patients are not protected against recurrent disease. H
Externí odkaz:
https://doaj.org/article/a556634f2abc4ca5953663dc7e0c93eb
Autor:
Rolf Billeskov, Thomas Lindenstrøm, Joshua Woodworth, Cristina Vilaplana, Pere-Joan Cardona, Joseph P. Cassidy, Rasmus Mortensen, Else Marie Agger, Peter Andersen
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world’s population with latent Mtb infection (LTBI), and 5–10% of the
Externí odkaz:
https://doaj.org/article/10955281844045e2a4b0e10ace68b190
Autor:
Dennis Christensen, Thomas Lindenstrøm, Gijsbert van de Wijdeven, Peter Andersen, Else Marie Agger
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15043 (2010)
Bioneedles are small hollow sugar based needles administered with a simple compressed air device. In the present study we investigate how incorporation of a subunit vaccine based on TB vaccine hybrid Ag85B-ESAT-6 adjuvated with CAF01 into Bioneedles
Externí odkaz:
https://doaj.org/article/a26c904a27a04f4b940f7b735120be5d
Autor:
Hans-Christian Ingerslev, Carlo Gunnar Ossum, Thomas Lindenstrøm, Michael Engelbrecht Nielsen
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9304 (2010)
Fibroblasts have shown to be an immune competent cell type in mammals. However, little is known about the immunological functions of this cell-type in lower vertebrates. A rainbow trout hypodermal fibroblast cell-line (RTHDF) was shown to be responsi
Externí odkaz:
https://doaj.org/article/dc8c739354224a848251564c7fccce5b