AsthmaMap: An interactive knowledge repository for mechanisms of asthma

Autor: Craig E. Wheelock, Rudi Balling, Valeriya Berzhitskaya, Ludovic Roy, Anke H. Maitland-van der Zee, Rupert W. Overall, Jan Hasenauer, Reinhard Schneider, Kian Fan Chung, Johann Pellet, Piotr Gawron, Richard G. Knowles, Bertrand De Meulder, Marek Ostaszewski, Alexander Mazein, Thomas Ligon, Charles Auffray, Tatiana S. Serebriyskaya, Olga Ivanova, Ratko Djukanovic, Irina Balaur, Graham Roberts, Sven-Erik Dahlén, Peter J. Sterk, Ian M. Adcock

Publikováno v: J. Allergy Clin. Immunol. 147, 853-856 (2021)
The journal of allergy and clinical immunology 147(3), 853-856 (2021). doi:10.1016/j.jaci.2020.11.032
Journal of allergy and clinical immunology, 147(3), 853-856. Mosby Inc.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59900d2068ac0883c074d0a8273b83e
https://pubmed.ncbi.nlm.nih.gov/33309742

The symmetry of the Kepler problem, the inverse Ligon-Schaaf mapping and the Birkhoff conjecture

Autor: Thomas Ligon

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203821 (2018)

The Ligon-Schaaf regularization (LS mapping) was introduced in 1976 and has been used several times. However, we are not aware of any direct usage of the inverse mapping, perhaps since it appears at first sight to be quite complex and involves the us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79e4ff6acb13c54de2972b528310095
https://pubmed.ncbi.nlm.nih.gov/30212553

Community-driven roadmap for integrated disease maps

Autor: Thomas Ligon, Stephan Gebel, Ugur Dogrusoz, Rudi Balling, Emmanuel Barillot, Jan Hasenauer, David P. Nickerson, Inna Kuperstein, Andrei Zinovyev, Reinhard Schneider, Charles Auffray, Alexander Mazein, Nicolas Le Novère, Daniel Weindl, Piotr Gawron, Anna Niarakis, Marek Ostaszewski, Ronan M. T. Fleming

Publikováno v: Briefings in Bioinformatics
Briefings in Bioinformatics, 2019, 20 (2), pp.659-670. ⟨10.1093/bib/bby024⟩
Briefings in Bioinformatics, Oxford University Press (OUP), 2019, 20 (2), pp.659-670. ⟨10.1093/bib/bby024⟩
Brief. Bioinform. 20, 659-670 (2019)

International audience; The Disease Maps Project builds on a network of scientific and clinical groups that exchange best practices, share informa-tion and develop systems biomedicine tools. The project aims for an integrated, highly curated and user

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77ca955c185f0c881e28ad2746b9be6
https://doi.org/10.31219/osf.io/hcuqa

Multi-Level Kinetic Model of mRNA Delivery via Transfection of Lipoplexes

Autor: Carolin Leonhardt, Joachim O. Rädler, Thomas Ligon

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e107148 (2014)

Recent work on the use of mRNA lipoplexes for gene delivery demonstrates the need for a mathematical model that simulates and predicts kinetics and transfection efficiency. The small copy numbers involved make it necessary to use stochastic models an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22346c6f231c9bf587db7d6c8b32e9d8
https://doi.org/10.1371/journal.pone.0107148

Single-cell mRNA transfection studies: Delivery, kinetics and statistics by numbers

Autor: Susanne Rappl, Carolin Leonhardt, Thomas Ligon, Jan-Timm Kuhr, Gerlinde Schwake, Joachim O. Rädler, Tobias Stögbauer

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. (4):679-688

In artificial gene delivery, messenger RNA (mRNA) is an attractive alternative to plasmid DNA (pDNA) since it does not require transfer into the cell nucleus. Here we show that, unlike for pDNA transfection, the delivery statistics and dynamics of mR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655b9189eac9218872114478cbb13e6f