Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Thomas Lemster"'
Autor:
Marie-Hélène David-Cordonnier, Thomas Lemster, Gaëlle Lenglet, Ulf Pindur, Christelle Dassi, Sabine Depauw
Publikováno v:
European Journal of Medicinal Chemistry. 44:3235-3252
In the context of the design and synthesis of DNA ligands, some new hetarene annelated carbazoles were synthesized. As lead structure the intercalating tetracyclic systems pyrido[2,3-a]- and pyrido[4,3-a]-carbazoles and in one case a thieno[2,3-a]-ca
Publikováno v:
The Journal of Neuroscience. 25:9358-9366
Based on theTorpedoacetylcholine receptor structure, Unwin and colleagues (Miyazawa et al., 2003; Unwin, 2005) hypothesized that the transduction of agonist binding to channel gate opening involves a “pin-into-socket” interaction between αV46 at
Autor:
Ulf Pindur, Thomas Lemster
Publikováno v:
Current Medicinal Chemistry. 8:1681-1698
Marine natural products, form a field of scientific endeavour, that has recently grown considerably. The isolation, biological evaluation, chemical properties and synthetic elaborations of products of marine organisms have attracted the attention of
Autor:
Ulf Pindur, Thomas Lemster
Publikováno v:
ChemInform. 29
Autor:
Thomas Lemster, Ulf Pindur
Publikováno v:
ChemInform. 30
Autor:
Marie-Hélène David-Cordonnier, Sabine Depauw, Gaelle Lenglet, Christelle Dassi, Ulf Pindur, Thomas Lemster
Publikováno v:
ChemInform. 40
Autor:
Thomas Lemster, Ulf Pindur
Publikováno v:
ChemInform. 38
Autor:
Thomas Lemster, Brigitte Baldeyrou, Amélie Lansiaux, Marie-Paule Hildebrand, Ulf Pindur, Christoph Keuser, Kerstin Benzschawel, Marie-Hélène David-Cordonnier
Publikováno v:
European journal of medicinal chemistry. 42(6)
In the context of the design and synthesis of minor groove binding and intercalating DNA ligands some new oligopyrrole carboxamides were synthesized. These hybrid molecules (combilexins) possess a variable and conformatively flexible spacer at the N-
Autor:
Ulf Pindur, Thomas Lemster
Publikováno v:
ChemInform. 37
Publikováno v:
Current medicinal chemistry. 12(24)
It is known that DNA is a well-characterized intracellular target but its size and sequential characteristics make it an elusive target for selective drug action. Binding of low molecular weight ligands to DNA causes a variety of significant biologic