Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Thomas Lemmin"'
Autor:
Patrick Roth, Jean-Marc Jeckelmann, Inken Fender, Zöhre Ucurum, Thomas Lemmin, Dimitrios Fotiadis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Glucose is the primary source of energy for many organisms and is efficiently taken up by bacteria through a dedicated transport system that exhibits high specificity. In Escherichia coli, the glucose-specific transporter IICBGlc serves as t
Externí odkaz:
https://doaj.org/article/1bb3e7ddac5643729ffc8194c467b3ca
Autor:
Noah Kleinschmidt, Thomas Lemmin
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract In recent years computational methods for molecular modeling have become a prime focus of computational biology and cheminformatics. Many dedicated systems exist for modeling specific classes of molecules such as proteins or small drug-like
Externí odkaz:
https://doaj.org/article/a88987de83c24074b776248ce9122bdb
Autor:
Stephan Hirschi, Thomas Lemmin, Nooraldeen Ayoub, David Kalbermatter, Daniele Pellegata, Zöhre Ucurum, Jürg Gertsch, Dimitrios Fotiadis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Microbial ion-pumping rhodopsins (MRs) are extensively studied retinal-binding membrane proteins. However, their biogenesis, including oligomerisation and retinal incorporation, remains poorly understood. The bacterial green-light absorbing
Externí odkaz:
https://doaj.org/article/a108a1ee9b9d4375998fcce708237c39
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Bacteria rely on two-component systems to sense environmental cues and regulate gene expression for adaptation. The PhoQ/PhoP system exemplifies this crucial role, playing a key part in sensing magnesium (Mg2+) levels, antimicrobial peptides
Externí odkaz:
https://doaj.org/article/8fb822edaa994e579c28ec55c2157766
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Cryo-EM structure determination of relatively small and flexible membrane proteins at high resolution is challenging. Increasing the size and structural features by binding of high affinity proteins to the biomolecular target allows for bett
Externí odkaz:
https://doaj.org/article/6f00c2e103714c4a90a407cbed14e528
Autor:
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V. Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D. Kouyos, John A. Robinson, Huldrych F. Günthard, Andreas Plückthun, Alexandra Trkola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resem
Externí odkaz:
https://doaj.org/article/ecac0450d3ce4cd7a9cab854f96059f2
Autor:
Hüseyin Ilgü, Jean-Marc Jeckelmann, David Kalbermatter, Zöhre Ucurum, Thomas Lemmin, Dimitrios Fotiadis
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background The L-arginine/agmatine transporter AdiC is part of the arginine-dependent extreme acid resistance system of the bacterium Escherichia coli and its pathogenic varieties such as strain E. coli O157:H7. At the present time, there is
Externí odkaz:
https://doaj.org/article/5a4b8474e2574d198278bd45bb5855ef
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The cryo-EM structure of pentameric green-light absorbing proteorhodopsin together with molecular dynamics simulations and functional studies provides insights into the proton translocation pathway and oligomerization, and a protonation-dependent mec
Externí odkaz:
https://doaj.org/article/be15953b5e8e49b3be8f4c74426e812d
Autor:
Bruk Mensa, Nicholas F Polizzi, Kathleen S Molnar, Andrew M Natale, Thomas Lemmin, William F DeGrado
Publikováno v:
eLife, Vol 10 (2021)
Transmembrane signaling proteins couple extracytosolic sensors to cytosolic effectors. Here, we examine how binding of Mg2+ to the sensor domain of an E. coli two component histidine kinase (HK), PhoQ, modulates its cytoplasmic kinase domain. We use
Externí odkaz:
https://doaj.org/article/d5bc844519104cae8d3da4e41b6883b8
Autor:
Thomas Lemmin, Cinque Soto
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background Carbohydrates are a class of large and diverse biomolecules, ranging from a simple monosaccharide to large multi-branching glycan structures. The covalent linkage of a carbohydrate to the nitrogen atom of an asparagine, a process
Externí odkaz:
https://doaj.org/article/61327db849ae44afaaa9a0f9b2d99882