Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Thomas Lavstsen"'
Autor:
Elena Ethel Vidal-Calvo, Anne Martin-Salazar, Swati Choudhary, Robert Dagil, Sai Sundar Rajan Raghavan, Lara Duvnjak, Mie Anemone Nordmaj, Thomas Mandel Clausen, Ann Skafte, Jan Oberkofler, Kaituo Wang, Mette Ø Agerbæk, Caroline Løppke, Amalie Mundt Jørgensen, Daria Ropac, Joana Mujollari, Shona Willis, Agnès Garcias López, Rebecca Louise Miller, Richard Torbjörn Gustav Karlsson, Felix Goerdeler, Yen-Hsi Chen, Ana R. Colaço, Yong Wang, Thomas Lavstsen, Agnieszka Martowicz, Irina Nelepcu, Mona Marzban, Htoo Zarni Oo, Maj Sofie Ørum-Madsen, Yuzhuo Wang, Morten A. Nielsen, Henrik Clausen, Michael Wierer, Dominik Wolf, Ismail Gögenur, Thor G. Theander, Nader Al-Nakouzi, Tobias Gustavsson, Mads Daugaard, Ali Salanti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One such embryonic signature tumors express is oncofetal chondroitin sulfate (ofCS),
Externí odkaz:
https://doaj.org/article/b0285b53e90a45a8a481845883fadcba
Autor:
Raphael A Reyes, Louise Turner, Isaac Ssewanyana, Prasanna Jagannathan, Margaret E Feeney, Thomas Lavstsen, Bryan Greenhouse, Sebastiaan Bol, Evelien M Bunnik
Publikováno v:
PLoS Pathogens, Vol 20, Iss 10, p e1012661 (2024)
Plasmodium falciparum infections elicit strong humoral immune responses to two main groups of antigens expressed by blood-stage parasites: merozoite antigens that are involved in the erythrocyte invasion process and variant surface antigens that medi
Externí odkaz:
https://doaj.org/article/ca9345f9891e45969dcbc2e454564131
Autor:
Ilary Riedmiller, Cyrielle Fougeroux, Rasmus W Jensen, Ikhlaq H Kana, Adam F Sander, Thor G Theander, Thomas Lavstsen, Louise Turner
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0302243 (2024)
The sequestration of Plasmodium falciparum-infected erythrocytes to the host endothelium is central to the pathogenesis of malaria. The sequestration is mediated by the parasite´s diverse Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
Externí odkaz:
https://doaj.org/article/9000c2c306034dd093a4dec13107e52d
Autor:
Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith AM Scholz, Helle Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael F Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington, Anna Bachmann
Publikováno v:
eLife, Vol 12 (2024)
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorp
Externí odkaz:
https://doaj.org/article/ee63f3338efa4b578bd3c5c0608fd5e0
Autor:
Eric Lyimo, Cyrielle Fougeroux, Anangisye Malabeja, Joyce Mbwana, Paul M. Hayuma, Edwin Liheluka, Louise Turner, Samwel Gesase, Thomas Lavstsen, John P. A. Lusingu, Daniel T. R. Minja, Christian W. Wang
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background African countries stand out globally as the region seemingly least affected by the COVID-19 pandemic, caused by the virus SARS-CoV-2. Besides a younger population and potential pre-existing immunity to a SARS-CoV-2-like virus, it
Externí odkaz:
https://doaj.org/article/eff79c4517d7451ca0c04a6980f0c34b
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Parasites use polymorphic gene families to evade the immune system or interact with the host. Assessing the diversity and expression of such gene families in pathogens can inform on the repertoire or host interaction phenotypes of
Externí odkaz:
https://doaj.org/article/a8cfdafe16a746229170d6208e49f49b
Autor:
Sai Sundar Rajan Raghavan, Robert Dagil, Mary Lopez-Perez, Julian Conrad, Maria Rosaria Bassi, Maria Del Pilar Quintana, Swati Choudhary, Tobias Gustavsson, Yong Wang, Pontus Gourdon, Michael Fokuo Ofori, Sebastian Boje Christensen, Daniel Thomas Remias Minja, Christentze Schmiegelow, Morten Agertoug Nielsen, Lea Barfod, Lars Hviid, Ali Salanti, Thomas Lavstsen, Kaituo Wang
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010924 (2022)
Malaria during pregnancy is a major global health problem caused by infection with Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected erythrocytes in the placenta. Here, erythrocytes infected by late blood-stage p
Externí odkaz:
https://doaj.org/article/085ab7f662214893a8138336c02f4d83
Autor:
Kaituo Wang, Robert Dagil, Thomas Lavstsen, Sandeep K. Misra, Charlotte B. Spliid, Yong Wang, Tobias Gustavsson, Daniel R. Sandoval, Elena Ethel Vidal-Calvo, Swati Choudhary, Mette Ø Agerbaek, Kresten Lindorff-Larsen, Morten A. Nielsen, Thor G. Theander, Joshua S. Sharp, Thomas Mandel Clausen, Pontus Gourdon, Ali Salanti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
In placental malaria, interactions between parasite protein VAR2CSA and human glycosaminoglycan chondroitin sulfate A (CS) sequesters infected red blood cells in the placenta. Here, the authors provide cryo-EM structures of VAR2CSA and placental CS,
Externí odkaz:
https://doaj.org/article/fd67b0fdc13e4bbbbe14bbcaf2e9d8b8
Autor:
Charlotte Harmsen, Louise Turner, Susan Thrane, Adam F. Sander, Thor G. Theander, Thomas Lavstsen
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-11 (2020)
Abstract Background During the erythrocytic cycle, Plasmodium falciparum malaria parasites express P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) that anchor the infected erythrocytes (IE) to the vascular lining of the host. The CIDRα1 domain
Externí odkaz:
https://doaj.org/article/29291b751fdf4d95952d96779e8f2e36
Autor:
Jens E V Petersen, Joseph W Saelens, Elizabeth Freedman, Louise Turner, Thomas Lavstsen, Rick M Fairhurst, Mahamadou Diakité, Steve M Taylor
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009659 (2021)
Sickle-trait hemoglobin protects against severe Plasmodium falciparum malaria. Severe malaria is governed in part by the expression of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) that are encoded by var genes, specifically those
Externí odkaz:
https://doaj.org/article/acbedbf62057449b8183853d3f2dc440