Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Thomas Langman"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Reactive microglia are a hallmark of age-related retinal degenerative diseases including age-related macular degeneration (AMD). These cells are capable of secreting neurotoxic substances that may aggravate inflammation that leads to loss of photorec
Externí odkaz:
https://doaj.org/article/9010401e16044aaa809ca8656a2ed1bd
Autor:
Mona Tabel, Anne Wolf, Manon Szczepan, Heping Xu, Herbert Jägle, Christoph Moehle, Mei Chen, Thomas Langmann
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Dysfunctional humoral and cellular innate immunity are key components in the development and progression of age-related macular degeneration (AMD). Specifically, chronically activated microglia and their disturbed regulatory syste
Externí odkaz:
https://doaj.org/article/77c6bbc88bbf4d9995992968dfb9aa4c
Autor:
Nafisa Nuzhat, Kristof Van Schil, Sandra Liakopoulos, Miriam Bauwens, Alfredo Dueñas Rey, Stephan Käseberg, Melanie Jäger, Jason R. Willer, Jennifer Winter, Hanh M. Truong, Nuria Gruartmoner, Mattias Van Heetvelde, Joachim Wolf, Robert Merget, Sabine Grasshoff-Derr, Jo Van Dorpe, Anne Hoorens, Heidi Stöhr, Luke Mansard, Anne-Françoise Roux, Thomas Langmann, Katharina Dannhausen, David Rosenkranz, Karl M. Wissing, Michel Van Lint, Heidi Rossmann, Friederike Häuser, Peter Nürnberg, Holger Thiele, Ulrich Zechner, Jillian N. Pearring, Elfride De Baere, Hanno J. Bolz
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Defects in primary or motile cilia result in a variety of human pathologies, and retinal degeneration is frequently associated with these so-called ciliopathies. We found that homozygosity for a truncating variant in CEP162, a centrosome and microtub
Externí odkaz:
https://doaj.org/article/5751fc3eb5124e36990ef17731c43da6
Autor:
Marek Bodzioch, Julian Pryjma, J. Stachura, Joanna Skrzeczyńska, Grzegorz Dyduch, Thomas Langman, Beata Kieć-Wilk, Małgorzata Malczewska-Malec, Anna Polus, Gerd Schmitz, Łukasz Partyka, J. Grzybowska, Aldona Dembinska-Kiec
Publikováno v:
Pure and Applied Chemistry. 78:1519-1537
Carotenoids and retinoids modulate growth and differentiation of a variety of cell types and are fundamental regulators of development. Endothelial cells play an important role in angiogenesis, which is essential for organogenesis and tissue remodeli
Autor:
Amir Saeed Khan, Thomas Langmann
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Retinal degenerative diseases significantly contribute to visual impairment and blindness. Microglia reactivity is a hallmark of neurodegenerative diseases including retinal cell death and immunomodulation emerges as a therapeutic
Externí odkaz:
https://doaj.org/article/4c3cd578252947a992e80eb978f209b4
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD
Externí odkaz:
https://doaj.org/article/2f3c188a202d4b068ecd2781ac80e7eb
Autor:
Thomas Langmann
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103662- (2021)
Externí odkaz:
https://doaj.org/article/efda60b052d9453e8e7b8087350252bb
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly. The neovascular (wet) form of AMD can be treated with intravitreal injections of different anti-vascular endothelial growth factor (VEG
Externí odkaz:
https://doaj.org/article/26a42f513604471e8e8cffb13386f456
Autor:
Verena Behnke, Thomas Langmann
Publikováno v:
Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100866- (2020)
Chronic activation of microglia is associated with retinal degeneration, which makes them a potential therapeutic target for retinal degenerative diseases including age-related macular degeneration (AMD). Interferon-beta (IFN-β) is a potent immune r
Externí odkaz:
https://doaj.org/article/4293d6c711de4570a37df92ed53c48a4
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature of the retina. The development of this disease is associated with the action of inflammatory factors that are connected to the activation of microglial cells,
Externí odkaz:
https://doaj.org/article/6e28d4a56c0a44ef90814713f7d6c83f