Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Thomas Landkildehus Lisle"'
Autor:
Hannah Jorinde Glöckner, Evelina Martinenaite, Thomas Landkildehus Lisle, Jacob Grauslund, Shamaila Ahmad, Özcan Met, Per Thor Straten, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTArginase-1 (Arg1) is expressed by regulatory myeloid cells in the tumor microenvironment (TME), where they play a pro-tumorigenic and T-cell suppressive role. Arg1-specific CD4+ and CD8+ memory T cells have been observed in both healthy indiv
Externí odkaz:
https://doaj.org/article/51ea7c2c79e84f9c92854df08a263289
Autor:
Morten Orebo Holmström, Morten Andersen, Sofie Traynor, Shamaila Munir Ahmad, Thomas Landkildehus Lisle, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Johnny T. Ottesen, Morten Frier Gjerstorff, Hans Carl Hasselbalch, Mads Hald Andersen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundTherapeutic cancer vaccination against mutant calreticulin (CALR) in patients with CALR-mutant (CALRmut) myeloproliferative neoplasms (MPN) induces strong T-cell responses against mutant CALR yet fails to demonstrate clinical activity. Infi
Externí odkaz:
https://doaj.org/article/ea1a4e7fa4a849529a58c4ed8bd4131d
Autor:
Mads Hald Andersen, Özcan Met, Inge Marie Svane, Morten Orebo Holmström, Thomas Landkildehus Lisle, Rasmus Erik Johansson Mortensen, Jane P Hasselby, Gro L Willemoe, Julia Johansen, Dorte L Nielsen, Inna M Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Circulating transforming growth factor-β (TGF-β)-specific T cells that recognize TGF-β-expressing immune regulatory cells have been described in patients with cancer. TGF-β-derived peptide vaccination modulates the tumor microenvironme
Externí odkaz:
https://doaj.org/article/86495d8680aa4a59a67aa19a352593ff
Autor:
Jacob Handlos Grauslund, Morten Orebo Holmström, Evelina Martinenaite, Thomas Landkildehus Lisle, Hannah Jorinde Glöckner, Daniel El Fassi, Uffe Klausen, Rasmus E. J. Mortensen, Nicolai Jørgensen, Lasse Kjær, Vibe Skov, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionArginase-1 (ARG1) and Programed death ligand-1 (PD-L1) play a vital role in immunosuppression in myeloproliferative neoplasms (MPNs) and directly inhibit T-cell activation and proliferation. We previously identified spontaneous T-cell res
Externí odkaz:
https://doaj.org/article/5bb1896ca9234691adc0750d751600e6
Autor:
Uffe Klausen, Jacob Handlos Grauslund, Nicolai Grønne Dahlager Jørgensen, Shamaila Munir Ahmad, Merete Jonassen, Stine Emilie Weis-Banke, Evelina Martinenaite, Lone Bredo Pedersen, Thomas Landkildehus Lisle, Anne Ortved Gang, Lisbeth Enggaard, Morten Hansen, Morten Orebo Holmström, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen, Mads Hald Andersen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chronic lymphocytic leukemia (CLL) patients with unmutated immunoglobulin heavy chain (IgHV) are at risk of early disease progression compared to patients with mutated IgHV. As a preventive strategy, we treated 19 previously untreated CLL patients wi
Externí odkaz:
https://doaj.org/article/84bc1f77bf5c4507a17a70aaa4b29f52
Autor:
Marco Donia, Mads Hald Andersen, Özcan Met, Lars Grøntved, Daniel Hargbøl Madsen, Inge Marie Svane, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has de
Externí odkaz:
https://doaj.org/article/fff8e87a81a74470aaa2d8cac2b4d443
Autor:
Rasmus Erik Johansson Mortensen, Morten Orebo Holmström, Thomas Landkildehus Lisle, Jane P Hasselby, Gro L Willemoe, Özcan Met, Inge Marie Svane, Julia Johansen, Dorte L Nielsen, Inna M Chen, Mads Hald Andersen
Publikováno v:
Mortensen, R E J, Holmström, M O, Lisle, T L, Hasselby, J P, Willemoe, G L, Met, Ö, Marie Svane, I, Johansen, J, Nielsen, D L, Chen, I M & Andersen, M H 2023, ' Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy ', Journal for ImmunoTherapy of Cancer, vol. 11, no. 3 . https://doi.org/10.1136/jitc-2022-006432
BackgroundCirculating transforming growth factor-β (TGF-β)-specific T cells that recognize TGF-β-expressing immune regulatory cells have been described in patients with cancer. TGF-β-derived peptide vaccination modulates the tumor microenvironmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6595dff01c8bd7afd842b26fd639af9a
https://curis.ku.dk/ws/files/341346441/e006432.full.pdf
https://curis.ku.dk/ws/files/341346441/e006432.full.pdf
Autor:
Stine Emilie Weis-Banke, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Morten Orebo Holmström, Mia Aaboe Jørgensen, Inge Marie Svane, Özcan Met, Niels Ødum, Daniel Hargbøl Madsen, Marco Donia, Lars Grøntved, Mads Hald Andersen
Publikováno v:
Weis-Banke, S E, Lisle, T L, Perez-Penco, M, Schina, A, Hübbe, M L, Siersbæk, M, Holmström, M O, Jørgensen, M A, Marie Svane, I, Met, Ö, Ødum, N, Madsen, D H, Donia, M, Grøntved, L & Andersen, M H 2022, ' Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells ', Journal for ImmunoTherapy of Cancer, vol. 10, no. 10, e005326 . https://doi.org/10.1136/jitc-2022-005326
BackgroundHigh expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a3e11990a28f3476ee2a8fc7032848
https://curis.ku.dk/ws/files/327473121/e005326.full.pdf
https://curis.ku.dk/ws/files/327473121/e005326.full.pdf