Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas LaBar"'
Autor:
Thomas LaBar, Christoph Adami
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Genetic drift can reduce fitness in small populations by counteracting selection against deleterious mutations. Here, LaBar and Adami demonstrate through a mathematical model and simulations that small populations tend to evolve to drift-robust fitne
Externí odkaz:
https://doaj.org/article/c10d3c4803664beebf258eb392972242
Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection.
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000397 (2019)
Populations often encounter changed environments that remove selection for the maintenance of particular phenotypic traits. The resulting genetic decay of those traits under relaxed selection reduces an organism's fitness in its prior environment. Ho
Externí odkaz:
https://doaj.org/article/53fed29e0c39435b8f67d2d2bd140f78
Autor:
Thomas LaBar, Christoph Adami
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 12, p e1005066 (2016)
A major aim of evolutionary biology is to explain the respective roles of adaptive versus non-adaptive changes in the evolution of complexity. While selection is certainly responsible for the spread and maintenance of complex phenotypes, this does no
Externí odkaz:
https://doaj.org/article/b6ab48f8a5f5494ab56e843d15ffce65
Publikováno v:
Curr Biol
Comparative genomics reveals an unexpected diversity in the molecular mechanisms underlying conserved cellular functions, such as DNA replication and cytokinesis. However, the genetic bases and evolutionary processes underlying this “molecular dive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce41dc5502719ada021a44ca9698759
https://europepmc.org/articles/PMC7295036/
https://europepmc.org/articles/PMC7295036/
Autor:
Christoph Adami, Thomas LaBar
Publikováno v:
Evolution in Action: Past, Present and Future ISBN: 9783030398309
Although extinction is ubiquitous throughout the history of life, the factors that drive extinction events are often difficult to decipher. Most studies of extinction focus on inferring causal factors from past extinction events, but these studies ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8029a70d29b8eeb0a12fa4ab2c2ddfbc
https://doi.org/10.1007/978-3-030-39831-6_14
https://doi.org/10.1007/978-3-030-39831-6_14
High mutation rates select for the evolution of mutational robustness where populations inhabit flat fitness peaks with little epistasis, protecting them from a mutational meltdown. Recent evidence suggests that a different effect protects small popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789cffcd75fab5f15450d5be351e1ef4
https://doi.org/10.1101/752535
https://doi.org/10.1101/752535
Publikováno v:
Artificial life. 25(3)
BackgroundPopulations exposed to a high mutation rate harbor abundant deleterious genetic variation, leading to depressed mean fitness. This reduction in mean fitness presents an opportunity for selection to restore adaptation through the evolution o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419f4532e48d06473ff92c92076ddb26
https://pubmed.ncbi.nlm.nih.gov/31397601
https://pubmed.ncbi.nlm.nih.gov/31397601
Publikováno v:
The 2018 Conference on Artificial Life.
A central goal of evolutionary biology is to explain the origins and distribution of diversity across life. Beyond species or genetic diversity, we also observe diversity in the circuits (genetic or otherwise) underlying complex functional traits. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564e1e6cdb57d9fcbd5eebba2d8915bd
https://doi.org/10.1162/isal_a_00115
https://doi.org/10.1162/isal_a_00115
Autor:
Thomas LaBar, Christoph Adami
Although extinction is ubiquitous throughout the history of life, insight into the factors that drive extinction events are often difficult to decipher. Most studies of extinction focus on inferring causal factors from past extinction events, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12eeabd8954cfaa99e7cd94da7cdd52