Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Thomas L. Vaughan"'
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background A key barrier to controlling esophageal adenocarcinoma (EAC) is identifying those most likely to benefit from screening and surveillance. We aimed to develop an online educational tool, termed IC-RISC™, for providers and patient
Externí odkaz:
https://doaj.org/article/d5ed05aba0ab4bf4a1aa9b6568461c47
Autor:
Patricia C. Galipeau, Kenji M. Oman, Thomas G. Paulson, Carissa A. Sanchez, Qing Zhang, Jerry A. Marty, Jeffrey J. Delrow, Mary K. Kuhner, Thomas L. Vaughan, Brian J. Reid, Xiaohong Li
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to protect against tetraploidy, aneuploidy, and chromosomal alterations in the metaplastic condition Barrett’s esophagus (BE) and to lower th
Externí odkaz:
https://doaj.org/article/9f94c7d2b67e427691f7f022843a64f1
Autor:
Patricia C. Galipeau, Kenji M. Oman, Thomas G. Paulson, Carissa A. Sanchez, Qing Zhang, Jerry A. Marty, Jeffrey J. Delrow, Mary K. Kuhner, Thomas L. Vaughan, Brian J. Reid, Xiaohong Li
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-1 (2019)
It was highlighted that in the original article [1] the Availability of data and materials section was incorrect.
Externí odkaz:
https://doaj.org/article/fca3a9cb2bce48b5a4ff8ae9ab6199a6
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008961 (2021)
Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal expansion (MSCE) model for cancer can be harnessed to identify biological processes that shap
Externí odkaz:
https://doaj.org/article/933bcd9832fc4c53bfa8ba5520dd0f72
Autor:
Mourad Wagdy Ali, Jianhong Chen, Li Yan, Xiaoyu Wang, James Y Dai, Thomas L Vaughan, Graham Casey, Matthew F Buas
Publikováno v:
Hum Mol Genet
Nineteen genetic susceptibility loci for esophageal adenocarcinoma (EAC) and its precursor Barrett’s esophagus (BE) have been identified through genome-wide association studies (GWAS). Clinical translation of such discoveries, however, has been hin
Autor:
Carlo C. Maley, Brian J. Reid, Thomas L. Vaughan, Patricia L. Blount, Xiaohong Li, Najaf A. Shah, Lauren M.F. Merlo
Neoplastic progression is an evolutionary process driven by the generation of clonal diversity and natural selection on that diversity within a neoplasm. We hypothesized that clonal diversity is associated with risk of progression to cancer. We obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ada34eb0f75c2a88742194e1dfd0e40
https://doi.org/10.1158/1940-6207.c.6544329.v1
https://doi.org/10.1158/1940-6207.c.6544329.v1
Autor:
Patricia L. Blount, Brian J. Reid, Thomas L. Vaughan, Steven G. Self, Carlo C. Maley, Mary K. Kuhner, Karen Liu, Carissa A. Sanchez, Patricia C. Galipeau, Thomas G. Paulson, Xiaohong Li
ROC for combined T1+T2 data. The model was trained by repeatedly using a randomly drawn 2/3 of the combined T1+T2 data for training, and testing on the reserved 1/3 of the data. The average AUC of 10,000 ROC from the reserved test data is AUC=0.86.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3827bb61c1126eb00ec68b0f9adff6b2
https://doi.org/10.1158/1940-6207.22526555.v1
https://doi.org/10.1158/1940-6207.22526555.v1
PDF file - 80K, Final multivariate logistic model for dysplastic Barrett's esophagus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3952e8dbe7863ac8ff355606b4a9b98b
https://doi.org/10.1158/1940-6207.22523896.v1
https://doi.org/10.1158/1940-6207.22523896.v1
Autor:
Carlo C. Maley, Brian J. Reid, Thomas L. Vaughan, Patricia L. Blount, Xiaohong Li, Najaf A. Shah, Lauren M.F. Merlo
Perspective on This Article from A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abf6ad0a0bb1beed111d0139ce1db79
https://doi.org/10.1158/1940-6207.22524591.v1
https://doi.org/10.1158/1940-6207.22524591.v1
Autor:
Brian J. Reid, Patricia L. Blount, Thomas L. Vaughan, Steven G. Self, Carlo C. Maley, Mary K. Kuhner, Robert D. Odze, Rumen L. Kostadinov, Cassandra L. Sather, Karen Liu, Jessica Arnaudo, Carissa A. Sanchez, Thomas G. Paulson, Patricia C. Galipeau, Xiaohong Li
PDF file 2119K, Supplementary Table S1, Cohort characteristics. Supplementary Table S2, Mean SCA and mean percent of probes with SCA per biopsy in time windows. Supplementary Table S3, SCA with similar frequency in progressors and nonprogressors in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c49ccd03a8c6123935d9fd9f729447
https://doi.org/10.1158/1940-6207.22524870
https://doi.org/10.1158/1940-6207.22524870