Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas L. Pulliam"'
Autor:
Carrow Wells, Yi Liang, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O’Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M. Couñago, Brittany Stork, Christopher G. Langendorf, Kevin Nay, Jonathan S. Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R. Means, Brian York, Donald P. McDonnell, John W. Scott, Daniel E. Frigo, David H. Drewry
Publikováno v:
Cells, Vol 12, Iss 2, p 287 (2023)
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a se
Externí odkaz:
https://doaj.org/article/22978372a9134263a1f17e8fa4cfa4d9
Autor:
Thomas L. Pulliam, Dominik Awad, Jenny J. Han, Mollianne M. Murray, Jeffrey J. Ackroyd, Pavithr Goli, Jonathan S. Oakhill, John W. Scott, Michael M. Ittmann, Daniel E. Frigo
Publikováno v:
Cells, Vol 11, Iss 12, p 1890 (2022)
Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo remains unclear. Moreover, while CAMKK2 is known to regulate systemic metabolis
Externí odkaz:
https://doaj.org/article/dc59b8044ecb48d8896b850966d1a71a
Autor:
Thomas L. Pulliam, Pavithr Goli, Dominik Awad, Chenchu Lin, Sandi R. Wilkenfeld, Daniel E. Frigo
Publikováno v:
Nature Reviews Urology. 19:367-380
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cd90795d9305673e06d19e154062e20
https://doi.org/10.1038/s41585-022-00588-z
https://doi.org/10.1038/s41585-022-00588-z
Autor:
Dominik Awad, Thomas L. Pulliam, Meredith Spradlin, Pham Hong-Anh Cao, Elavarasan Subramani, Tristen V. Tellman, Caroline F. Ribeiro, Hubert Pakula, Jeffrey J. Ackroyd, Mollianne M. Murray, Jenny J. Han, Badrajee Piyarathna, Justin M. Drake, Michael M. Ittmann, Cristian Coarfa, Mary C. Farach-Carson, Massimo Loda, Livia S. Eberlin, Daniel E. Frigo
SummaryLipid metabolism plays a central role in prostate cancer. To date, the major focus on prostate cancer lipid metabolism has centered onde novolipogenesis and lipid uptake with little consideration for how cancer cells access these lipids once t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e86730db8380faa6251dbcc590f0e44
https://doi.org/10.1101/2022.11.02.514910
https://doi.org/10.1101/2022.11.02.514910
Autor:
Thomas L, Pulliam, Dominik, Awad, Jenny J, Han, Mollianne M, Murray, Jeffrey J, Ackroyd, Pavithr, Goli, Jonathan S, Oakhill, John W, Scott, Michael M, Ittmann, Daniel E, Frigo
Publikováno v:
Cells. 11(12)
Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo remains unclear. Moreover, while CAMKK2 is known to regulate systemic metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5817c09091fbc5ed3ad677af4364557c
https://pubmed.ncbi.nlm.nih.gov/35741020
https://pubmed.ncbi.nlm.nih.gov/35741020
Autor:
William J. Zuercher, Christopher G. Langendorf, Rafael M. Couñago, Chenchu Lin, Alfredo Picado, Mohammad Anwar Hossain, Jonathan S. Oakhill, Dominik Awad, Joseph R. Pilotte, David H. Drewry, Carolina M. C. Catta-Preta, Daniel E. Frigo, Carrow I. Wells, P.Z. Ramos, Christopher R. M. Asquith, Sean N. O’Byrne, Timothy M. Willson, Louisa Temme, A.S. Santiago, Kevin Nay, Thomas L. Pulliam, John W. Scott, Yi Liang, Benjamin J. Eduful
Publikováno v:
Journal of Medicinal Chemistry
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbcff8ed683ad253b52fbd8a7704dcb
https://acuresearchbank.acu.edu.au/item/8x148/hinge-binder-scaffold-hopping-identifies-potent-calcium-calmodulin-dependent-protein-kinase-kinase-2-camkk2-inhibitor-chemotypes
https://acuresearchbank.acu.edu.au/item/8x148/hinge-binder-scaffold-hopping-identifies-potent-calcium-calmodulin-dependent-protein-kinase-kinase-2-camkk2-inhibitor-chemotypes
Autor:
Chenchu Lin, David H. Drewry, Carrow I. Wells, Joseph R. Pilotte, John W. Scott, Benjamin J. Eduful, Yi Liang, Rafael M. Couñago, Carolina M. C. Catta-Preta, Alfredo Picado, Sean N. O’Byrne, Jonathan S. Oakhill, Dominik Awad, Christopher G. Langendorf, Christopher R. M. Asquith, Timothy M. Willson, Thomas L. Pulliam, Louisa Temme, Daniel E. Frigo, William J. Zuercher, P.Z. Ramos, A.S. Santiago, Kevin Nay
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103f4b3c66ec89afbef05608bfa9d132
https://doi.org/10.26434/chemrxiv.13484763
https://doi.org/10.26434/chemrxiv.13484763
Autor:
Alicia M. Blessing, Sandi R. Wilkenfeld, Yan Shi, Mollianne M. Murray, Chenchu Lin, Thomas L. Pulliam, Jenny J. Han, Sonja N. Brun, Michael M. Ittmann, Alexander H. Pham, Daniel E. Frigo, Kevin Duong, Reuben J. Shaw
Publikováno v:
Oncogene
Previous work has suggested androgen receptor (AR) signaling mediates cancer progression in part through the modulation of autophagy. Accordingly, we demonstrate that chloroquine, an inhibitor of autophagy, can inhibit tumor growth in preclinical mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caec5d87f6d259c5e8e76134301da4a7
https://doi.org/10.1101/2020.06.02.130088
https://doi.org/10.1101/2020.06.02.130088
Publikováno v:
Current Opinion in Pharmacology. 41:1-11
Although androgen deprivation therapy (ADT) is initially effective for the treatment of progressive prostate cancer, it inevitably fails due to the onset of diverse resistance mechanisms that restore androgen receptor (AR) signaling. Thus, AR remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c257fd37699835fc31e816e37b16ecd2
https://doi.org/10.1016/j.coph.2018.03.002
https://doi.org/10.1016/j.coph.2018.03.002
Autor:
Thomas L. Pulliam, David A. Bader, Shivanand Pudakalakatti, Sandi R. Wilkenfeld, Prasanta Dutta, Sean E. McGuire, Dominik Awad, Chenchu Lin, Pratip K. Bhattacharya, Travis C. Salzillo, Daniel E. Frigo, Mark Titus
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030326555
Adv Exp Med Biol
Adv Exp Med Biol
Cancers must alter their metabolism to satisfy the increased demand for energy and building blocks that are required to create a rapidly growing tumor. Further, for cancer cells to thrive, they must also adapt to cope with an often changing tumor mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7103e60de4261a150f83bdf8da68f9
https://doi.org/10.1007/978-3-030-32656-2_10
https://doi.org/10.1007/978-3-030-32656-2_10