Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Thomas L. McCarthy"'
Autor:
Thomas L. McCarthy, Chanyoung Park, Michael Centrella, Dong Chen, Ahmed K. Alomari, Gilbert W. Moeckel, Li Chen, Zhiyong Chen
Publikováno v:
Gene. 531:23-30
In addition to its role in regulation of salt transport in the kidney, the mineralocorticoid hormone aldosterone plays an independent role as a mediator of kidney injury and progression of chronic kidney disease. Studies in both animal models and pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730588ad281dfa3b6ed72efe6bcc07d5
https://doi.org/10.1016/j.gene.2013.08.047
https://doi.org/10.1016/j.gene.2013.08.047
Autor:
Michael Centrella, Thomas L. McCarthy
Publikováno v:
Steroids. 77:174-184
Hormone activated estrogen receptors (ERs) have long been appreciated as potent mediators of gene expression in female reproductive tissues. These highly targeted responses likely evolved from more elemental roles in lower organisms, in agreement wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05080baa29bffe95b0b3114fb0c6acef
https://doi.org/10.1016/j.steroids.2011.10.016
https://doi.org/10.1016/j.steroids.2011.10.016
Autor:
Dong Chen, Michael Centrella, Thomas L. McCarthy, Zhonghai Chen, Yuning Zhang, Gilbert W. Moeckel
Publikováno v:
Cellular Physiology and Biochemistry. 30:151-159
Elevated plasma phosphate levels are signifcantly associated with progression of chronic kidney disease (CKD). Interstitial fibrosis is an important factor in the progression of CKD. In this study we investigate the role of inorganic phosphate in sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94197a48fb84d1e4dbc8cccb47b336a
https://doi.org/10.1159/000339054
https://doi.org/10.1159/000339054
Publikováno v:
Molecular Biology Reports. 37:2629-2634
Cyclical mechanical strain is considered an important component in flexor tendon cell activation to prevent adhesions and enhance the healing process after tissue injury or surgery, but the biochemical events associated with this remain unclear. To a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40421e1455d91bc30bf6fc75245f6ee4
https://doi.org/10.1007/s11033-009-9788-8
https://doi.org/10.1007/s11033-009-9788-8
Autor:
Thomas L. McCarthy, Michael Centrella
Publikováno v:
Gene. 573(1)
Osteoblasts respond to many growth factors including IGF-I and TGF-β, which themselves are sensitive to other bone growth regulators. Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6539da2c5282fdd00b8f6478d51c4bd
https://pubmed.ncbi.nlm.nih.gov/26187065
https://pubmed.ncbi.nlm.nih.gov/26187065
Autor:
Rebecca G. Wells, Michael Centrella, Kenneth K. Kim, Weizhong Chang, Thomas L. McCarthy, Changhua Ji, Caren M. Gundberg
Publikováno v:
Gene. 379:175-184
Transforming growth factor-beta (TGF-beta) has potent, cell phenotype restricted effects. In bone, it controls multiple activities by osteoblasts through three predominant receptors. Of these, the relative amounts of TGF-beta receptor I (TbetaRI) var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd3264df1a792fac17f7b553f0681dd
https://doi.org/10.1016/j.gene.2006.05.005
https://doi.org/10.1016/j.gene.2006.05.005
Autor:
Lucia R. Languino, Loredana Moro, Hira Lal Goel, Natalia Teider, Thomas L. McCarthy, Albert J. Wong, Michael Centrella, Ersilia Marra, Michael King, Marina Holgado-Madruga
Publikováno v:
Cancer Research. 66:331-342
The interactions between cancer cells and the extracellular matrix (ECM) regulate cancer progression. The β1C and β1A integrins, two cytoplasmic variants of the β1 integrin subfamily, are differentially expressed in prostate cancer. Using gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a19b4d995ba32ea5d1b79ac128ebae7
https://doi.org/10.1158/0008-5472.can-05-2588
https://doi.org/10.1158/0008-5472.can-05-2588
Autor:
Michael Centrella, Sylvia Christakos, Thomas L. McCarthy, Xiaorong Peng, Paul N. MacDonald, Christian Trautwein, Puneet Dhawan, Amelia L. M. Sutton, Colleen M. Croniger
Publikováno v:
Molecular and Cellular Biology. 25:472-487
1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] induces the synthesis of 25-hydroxyvitamin D(3) 24-hydroxylase [24(OH)ase], an enzyme involved in its catabolism, thereby regulating its own metabolism. Here we demonstrate that CCAAT enhancer binding prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262401a83b3b8af1dc71e4219e8dfc9c
https://doi.org/10.1128/mcb.25.1.472-487.2005
https://doi.org/10.1128/mcb.25.1.472-487.2005
Publikováno v:
Gene. 345:225-235
Although ambient levels of estradiol and synthesis of the osteoblast growth factor IGF-I are inversely related in vivo, estradiol has little or no direct effect on igf1 gene expression in rat osteoblasts in vitro. Rather, estradiol suppresses the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f370bce25217302023223181004808
https://doi.org/10.1016/j.gene.2004.11.017
https://doi.org/10.1016/j.gene.2004.11.017
Publikováno v:
Molecular Endocrinology. 18:1120-1130
Alternative mechanisms of steroid action, through both traditional nuclear receptors and indirect pathways of gene activation, are emerging. Recent studies suggest that the synthetic steroid, 4-estrene-3alpha,17beta-diol (estren), has nongenotropic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791abd2dccec416ad3181344ecbed11f
https://doi.org/10.1210/me.2003-0491
https://doi.org/10.1210/me.2003-0491