Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Thomas L. Leto"'
Autor:
Geoffrey Hall, Ágnes Donkó, Cristina Pratt, Julie J. Kim-Chang, Paul L. Martin, Amy P. Stallings, John W. Sleasman, Steven M. Holland, Amy P. Hsu, Thomas L. Leto, Talal Mousallem
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
We report the case of a 1-week-old male born full-term, who had two inconclusive severe combined immunodeficiency (SCID) newborn screens and developed scalp cellulitis and Escherichia coli bacteremia. He did not pass early confirmatory hearing screen
Externí odkaz:
https://doaj.org/article/378194d6bbd641198e83f5f2775078f5
Autor:
Daniel J. Lagal, J. Antonio Bárcena, Raquel Requejo-Aguilar, C. Alicia Padilla, Thomas L. Leto
Publikováno v:
Advances in Redox Research, Vol 9, Iss , Pp 100080- (2023)
The NADPH oxidase 1 (NOX1) complex formed by proteins NOX1, p22phox, NOXO1, NOXA1, and RAC1 plays an important role in the generation of superoxide and other reactive oxygen species (ROS) which are involved in normal and pathological cell functions d
Externí odkaz:
https://doaj.org/article/4b13956b20454fb898a7e2972aa6a0fc
Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
Autor:
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102611- (2023)
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzym
Externí odkaz:
https://doaj.org/article/31bbeff5a1be41638e89f840fa625181
Autor:
Amy P. Hsu, Agnieszka Korzeniowska, Cynthia C. Aguilar, Jingwen Gu, Eric Karlins, Andrew J. Oler, Gang Chen, Glennys V. Reynoso, Joie Davis, Alexandria Chaput, Tao Peng, Ling Sun, Justin B. Lack, Derek J. Bays, Ethan R. Stewart, Sarah E. Waldman, Daniel A. Powell, Fariba M. Donovan, Jigar V. Desai, Nima Pouladi, Debra A. Long Priel, Daisuke Yamanaka, Sergio D. Rosenzweig, Julie E. Niemela, Jennifer Stoddard, Alexandra F. Freeman, Christa S. Zerbe, Douglas B. Kuhns, Yves A. Lussier, Kenneth N. Olivier, Richard C. Boucher, Heather D. Hickman, Jeffrey Frelinger, Joshua Fierer, Lisa F. Shubitz, Thomas L. Leto, George R. Thompson III, John N. Galgiani, Michail S. Lionakis, Steven M. Holland
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Disseminated coccidioidomycosis (DCM) is caused by Coccidioides, pathogenic fungi endemic to the southwestern United States and Mexico. Illness occurs in approximately 30% of those infected, less than 1% of whom develop disseminated disease. To addre
Externí odkaz:
https://doaj.org/article/cebc40ab082748549ea91e23e65f0242
Autor:
Daniel J. Lagal, María J. López-Grueso, José R. Pedrajas, Thomas L. Leto, J. Antonio Bárcena, Raquel Requejo-Aguilar, C. Alicia Padilla
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1153 (2023)
Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxin family, has peroxidase, phospholipase A2 (PLA2), and lysophosphatidylcholine (LPC) acyltransferase (LPCAT) activities. It has been associated with tumor progression and can
Externí odkaz:
https://doaj.org/article/1394d24c2cbe49ad8267f97876552f02
Autor:
Oskar Schnappauf, Liane Heale, Dilan Dissanayake, Wanxia L. Tsai, Massimo Gadina, Thomas L. Leto, Daniel L. Kastner, Harry L. Malech, Douglas B. Kuhns, Ivona Aksentijevich, Ronald M. Laxer
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-8 (2021)
Abstract Background Biallelic loss-of-function variants in NCF1 lead to reactive oxygen species deficiency and chronic granulomatous disease (CGD). Heterozygosity for the p.Arg90His variant in NCF1 has been associated with susceptibility to systemic
Externí odkaz:
https://doaj.org/article/6efcb34007d44450a012b400fd464468
Autor:
Fong-Fong Chu, R. Steven Esworthy, James H. Doroshow, Helmut Grasberger, Agnes Donko, Thomas L. Leto, Qiang Gao, Binghui Shen
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 144-156 (2017)
Mice deficient in glutathione peroxidase (GPx)-1 and -2 (GPx1-/-GPx2-/- double knockout or DKO mice) develop very-early-onset (VEO) ileocolitis, suggesting that lack of defense against reactive oxygen species (ROS) renders susceptibility to intestina
Externí odkaz:
https://doaj.org/article/f1b2dd46bb0c4d9e8d38953ecf61e485
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 235 (2021)
Previously, we have shown TGF-β-induced NOX4 expression is involved in the epithelial-to-mesenchymal transition (EMT), a process critical for cancer metastasis, and that wild-type (WT) and mutant (Mut) p53 have divergent effects on TGF-β induction
Externí odkaz:
https://doaj.org/article/8b4c0155386d46c8b06ea7264e6cac9b
Autor:
Miklós Geiszt, Thomas L. Leto
Publikováno v:
The Scientific World Journal, Vol 1, Pp 130-130 (2001)
Externí odkaz:
https://doaj.org/article/df3ffd398c934659bc9f047f2e8d9ec1
Publikováno v:
Free Radical Biology and Medicine. 199:17-25