Effects of a lower versus a higher oxygenation target in intensive care unit patients with chronic obstructive pulmonary disease and acute hypoxaemic respiratory failure: a subgroup analysis of a randomised clinical trial

Autor: Maria B. Nielsen, Thomas L. Klitgaard, Ulla M. Weinreich, Frederik M. Nielsen, Anders Perner, Olav L. Schjørring, Bodil S. Rasmussen

Publikováno v: BJA Open, Vol 10, Iss , Pp 100281- (2024)

Background: Oxygen supplementation is ubiquitous in intensive care unit (ICU) patients with chronic obstructive pulmonary disease (COPD) and acute hypoxaemia, but the optimal oxygenation target has not been established. Methods: This was a pre-planne

Externí odkaz: https://doaj.org/article/d49eedc4dc094a3b81af4c9e7db275f8

Lower or higher oxygenation targets for acute hypoxemic respiratory failure

Autor: Olav L, Schjørring, Thomas L, Klitgaard, Anders, Perner, Jørn, Wetterslev, Theis, Lange, Martin, Siegemund, Minna, Bäcklund, Frederik, Keus, Jon H, Laake, Matthew, Morgan, Katrin M, Thormar, Søren A, Rosborg, Jannie, Bisgaard, Annette E S, Erntgaard, Anne-Sofie H, Lynnerup, Rasmus L, Pedersen, Elena, Crescioli, Theis C, Gielstrup, Meike T, Behzadi, Lone M, Poulsen, Stine, Estrup, Jens P, Laigaard, Cheme, Andersen, Camilla B, Mortensen, Björn A, Brand, Jonathan, White, Inge-Lise, Jarnvig, Morten H, Møller, Lars, Quist, Morten H, Bestle, Martin, Schønemann-Lund, Maj K, Kamper, Mathias, Hindborg, Alexa, Hollinger, Caroline E, Gebhard, Núria, Zellweger, Christian S, Meyhoff, Mathias, Hjort, Laura K, Bech, Thorbjørn, Grøfte, Helle, Bundgaard, Lars H M, Østergaard, Maria A, Thyø, Thomas, Hildebrandt, Bülent, Uslu, Christoffer G, Sølling, Nette, Møller-Nielsen, Anne C, Brøchner, Morten, Borup, Marjatta, Okkonen, Willem, Dieperink, Ulf G, Pedersen, Anne S, Andreasen, Lone, Buus, Tayyba N, Aslam, Robert R, Winding, Joerg C, Schefold, Stine B, Thorup, Susanne A, Iversen, Janus, Engstrøm, Maj-Brit N, Kjær, Bodil S, Rasmussen, P, Bhachu

Publikováno v: Schjørring, O L, Klitgaard, T L, Perner, A, Wetterslev, J, Lange, T, Siegemund, M, Bäcklund, M, Keus, F, Laake, J H, Morgan, M, Thormar, K M, Rosborg, S A, Bisgaard, J, Erntgaard, A E S, Lynnerup, A S H, Pedersen, R L, Crescioli, E, Gielstrup, T C, Behzadi, M T, Poulsen, L M, Estrup, S, Laigaard, J P, Andersen, C, Mortensen, C B, Brand, B A, White, J, Jarnvig, I L, Møller, M H, Quist, L, Bestle, M H, Schønemann-Lund, M, Kamper, M K, Hindborg, M, Hollinger, A, Gebhard, C E, Zellweger, N, Meyhoff, C S, Hjort, M, Bech, L K, Grøfte, T, Bundgaard, H, Østergaard, L H M, Thyø, M A, Hildebrandt, T, Uslu, B, Sølling, C G, Møller-Nielsen, N, Brøchner, A C, Buus, L, Winding, R R & HOT-ICU Investigators 2021, ' Lower or higher oxygenation targets for acute hypoxemic respiratory failure ', New England Journal of Medicine, vol. 384, no. 14, pp. 1301-1311 . https://doi.org/10.1056/NEJMoa2032510
Schjørring, O L, Klitgaard, T L, Perner, A, Wetterslev, J, Lange, T, Siegemund, M, Bäcklund, M, Keus, F, Laake, J H, Morgan, M, Thormar, K M, Rosborg, S A, Bisgaard, J, Erntgaard, A E S, Lynnerup, A-S H, Pedersen, R L, Crescioli, E, Gielstrup, T C, Behzadi, M T, Poulsen, L M, Estrup, S, Laigaard, J P, Andersen, C, Mortensen, C B, Brand, B A, White, J, Jarnvig, I-L, Møller, M H, Quist, L, Bestle, M H, Schønemann-Lund, M, Kamper, M K, Hindborg, M, Hollinger, A, Gebhard, C E, Zellweger, N, Meyhoff, C S, Hjort, M, Bech, L K, Grøfte, T, Bundgaard, H, Østergaard, L H M, Thyø, M A, Hildebrandt, T, Uslu, B, Sølling, C G, Møller-Nielsen, N, Brøchner, A C, Borup, M, Okkonen, M, Dieperink, W, Pedersen, U G, Andreasen, A S, Buus, L, Aslam, T N, Winding, R R, Schefold, J C, Thorup, S B, Iversen, S A, Engstrøm, J, Kjær, M-B N & Rasmussen, B S 2021, ' Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure ', New England Journal of Medicine, vol. 384, no. 14, pp. 1301-1311 . https://doi.org/10.1056/NEJMoa2032510
Schjorring, O L, Klitgaard, T L, Perner, A, Wetterslev, J, Lange, T, Siegemund, M, Backlund, M, Keus, F, Laake, J H, Morgan, M, Thormar, K M, Rosborg, S A, Bisgaard, J, Erntgaard, A E S, Lynnerup, A-S H, Pedersen, R L, Crescioli, E, Gielstrup, T C, Behzadi, M T, Poulsen, L M, Estrup, S, Laigaard, J P, Andersen, C, Mortensen, C B, Brand, B A, White, J, Jarnvig, I-L, Møller, M H, Quist, L, Bestle, M H, Schonemann-Lund, M, Kamper, M K, Hindborg, M, Hollinger, A, Gebhard, C E, Zellweger, N, Meyhoff, C S, Hjort, M, Bech, L K, Grofte, T, Bundgaard, H, Ostergaard, L H M, Thyo, M A, Hildebrandt, T, Uslu, B, Solling, C G, Pedersen, U G, Andreasen, A S, Kjaer, M-B N, Rasmussen, B S & HOT-ICU Investigators 2021, ' Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure ', New England Journal of Medicine, vol. 384, no. 14, pp. 1301-1311 . https://doi.org/10.1056/NEJMoa2032510
Pedersen, U G, Andreasen, A S, Buus, L, Winding, R, Thorup, S B, Iversen, S A, Engstrøm, J, Kjaer, M-B N, Rasmussen, B S & HOT-ICU Investigators 2021, ' Lower or higher oxygenation targets for acute hypoxemic respiratory failure ', New England Journal of Medicine, vol. 384, no. 14, pp. 1301-1311 . https://doi.org/10.1056/NEJMoa2032510
The New England journal of medicine, 384(14), 1301-1311. Massachusetts Medical Society
New England Journal of Medicine, 384(14), 1301-1311. MASSACHUSETTS MEDICAL SOC

BACKGROUND Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c062fc70f0d6e8c45d7834dcc1c52c8
https://pure.au.dk/portal/da/publications/lower-or-higher-oxygenation-targets-for-acute-hypoxemic-respiratory-failure(deb0a677-7e6f-45fb-b46a-c6f39005e16d).html