Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Thomas L. Kash"'
Autor:
Dipanwita Pati, Lisa R. Taxier, Mengfan Xia, Sophia I. Lee, Sara Y. Conley, Tori Sides, Kristen M. Boyt, Avery C. Hunker, Larry S. Zweifel, Thomas L. Kash
Publikováno v:
Addiction Neuroscience, Vol 11, Iss , Pp 100157- (2024)
Dysregulation of the dopamine (DA) system is a hallmark of substance use disorders, including alcohol use disorder (AUD). Of the DA receptor subtypes, the DA D2 receptors (D2Rs) play a key role in the reinforcing effects of alcohol. D2Rs are expresse
Externí odkaz:
https://doaj.org/article/bbb5fbfa91bd4021b419202c30ff7ee0
Autor:
Khairunisa Mohamad Ibrahim, Nicolas Massaly, Hye-Jean Yoon, Rossana Sandoval, Allie J. Widman, Robert J. Heuermann, Sidney Williams, William Post, Sulan Pathiranage, Tania Lintz, Azra Zec, Ashley Park, Waylin Yu, Thomas L. Kash, Robert W. Gereau, Jose A. Morón
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The hippocampus is pivotal in integrating emotional processing, learning, memory, and reward-related behaviors. The dorsal hippocampus (dHPC) is particularly crucial for episodic, spatial, and associative memory, and has been shown to be nec
Externí odkaz:
https://doaj.org/article/87fdb1df68f64020b4bcdb032e7d7959
Autor:
Olivia B. Levine, Mary Jane Skelly, John D. Miller, Jean K. Rivera-Irizarry, Sydney A. Rowson, Jeffrey F. DiBerto, Jennifer A. Rinker, Todd E. Thiele, Thomas L. Kash, Kristen E. Pleil
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Bed nucleus of the stria terminalis (BNST) neurons that synthesize and release the stress neuropeptide corticotropin-releasing factor drive binge alcohol drinking and anxiety. The authors describe a complex feedforward inhibitory PVTVGLUT2-BNSTCRF ci
Externí odkaz:
https://doaj.org/article/a8c0c1c246d94234990664f016ba912d
Publikováno v:
Addiction Neuroscience, Vol 3, Iss , Pp 100023- (2022)
Binge drinking is a common pattern of excessive alcohol consumption associated with Alcohol Use Disorder (AUD) and unraveling the neurocircuitry that promotes this type of drinking is critical to the development of novel therapeutic interventions. Th
Externí odkaz:
https://doaj.org/article/59a700f45b0247dfbc49516e4fe7530d
Autor:
Waylin Yu, Christina M. Caira, Natalia del R. Rivera Sanchez, Garrett A. Moseley, Thomas L. Kash
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The bed nucleus of the stria terminalis (BNST) plays an emerging role in pain regulation. Pharmacological studies have found that inhibiting corticotropin-releasing factor (CRF) signaling in the BNST can selectively mitigate the sensory and
Externí odkaz:
https://doaj.org/article/b72d8daaf1964bbaacd0c1f2805786fa
Autor:
Sung-Ho Lee, Margaret A. Broadwater, Woomi Ban, Tzu-Wen Winnie Wang, Hyeon-Joong Kim, Jaiden Seongmi Dumas, Ryan P. Vetreno, Melissa A. Herman, A. Leslie Morrow, Joyce Besheer, Thomas L. Kash, Charlotte A. Boettiger, Donita L. Robinson, Fulton T. Crews, Yen-Yu Ian Shih
Publikováno v:
NeuroImage, Vol 243, Iss , Pp 118541- (2021)
Resting-state functional magnetic resonance imaging (fMRI) has drastically expanded the scope of brain research by advancing our knowledge about the topologies, dynamics, and interspecies translatability of functional brain networks. Several database
Externí odkaz:
https://doaj.org/article/eb50d64d64ad42faa983f0c8ab2cf8b8
Autor:
Nicole A. Crowley, Daniel W. Bloodgood, J. Andrew Hardaway, Alexis M. Kendra, Jordan G. McCall, Ream Al-Hasani, Nora M. McCall, Waylin Yu, Zachary L. Schools, Michael J. Krashes, Bradford B. Lowell, Jennifer L. Whistler, Michael R. Bruchas, Thomas L. Kash
Publikováno v:
Cell Reports, Vol 14, Iss 12, Pp 2774-2783 (2016)
Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate relea
Externí odkaz:
https://doaj.org/article/1e77c85eb79e463d9b87426cfc36833a
Autor:
Lara S Hwa, Sofia Neira, Meghan E Flanigan, Christina M Stanhope, Melanie M Pina, Dipanwita Pati, Olivia J Hon, Waylin Yu, Emily Kokush, Rachel Calloway, Kristen Boyt, Thomas L Kash
Publikováno v:
eLife, Vol 10 (2021)
Externí odkaz:
https://doaj.org/article/2c0796aba3494937bed38454bf92b203
Publikováno v:
The Journal of Neuroscience. 43:709-721
The bed nucleus of the stria terminalis (BNST) is a component of the extended amygdala that regulates motivated behavior and affective states and plays an integral role in the development of alcohol-use disorder (AUD). The dorsal subdivision of the B
Autor:
Lara S Hwa, Sofia Neira, Meghan E Flanigan, Christina M Stanhope, Melanie M Pina, Dipanwita Pati, Olivia J Hon, Waylin Yu, Emily Kokush, Rachel Calloway, Kristen Boyt, Thomas L Kash
Publikováno v:
eLife, Vol 9 (2020)
Maladaptive responses to stress are a hallmark of alcohol use disorder, but the mechanisms that underlie this are not well characterized. Here, we show that kappa opioid receptor signaling in the bed nucleus of the stria terminalis (BNST) is a critic
Externí odkaz:
https://doaj.org/article/4104ba0a03f344c28e976ea14ee11ef8