Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thomas L. Gonzalez"'
Autor:
Sandra L. Grimm, Guowei Gu, Sarah K. Herzog, Thomas L. Gonzalez, Hangqing Lin, Amanda R. Beyer, Yassine Rechoum, Tasneem Bawa-Khalfe, Ashfia F. Khan, Lili Du, W. Fraser Symmans, Ralf Kittler, Cristian Coarfa, Suzanne A.W. Fuqua
Publikováno v:
Cancer Research. 82:PD1-07
Background: Acquired ESR1 mutations are a dominant driver of distant metastasis in metastatic breast cancer, inducing a basal-like phenotype that is relatively resistant to ER antagonists with decreased progression free survival. The majority of ER+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943b176fbd5f57b73ecf1d90e7f894aa
https://doi.org/10.1158/1538-7445.sabcs21-pd1-07
https://doi.org/10.1158/1538-7445.sabcs21-pd1-07
Publikováno v:
Toxicology
Breast cancer is the most diagnosed malignancy among women in the United States. Approximately 70% of breast tumors express estrogen receptor alpha and are deemed ER-positive. ER-positive breast tumors depend upon endogenous estrogens to promote ER-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20415c15ab4a4d956247ddbb0b962e2
https://doi.org/10.1016/j.tox.2019.03.014
https://doi.org/10.1016/j.tox.2019.03.014
Publikováno v:
Computational Toxicology. 10:1-16
Crystal structures exist for human, but not rodent, estrogen receptor-α ligand-binding domain (ERα-LBD). Consequently, rodent studies involving binding of compounds to ERα-LBD are limited in their molecular-level interpretation and extrapolation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc45fb92faa55078039da666a76514ca
https://doi.org/10.1016/j.comtox.2018.11.003
https://doi.org/10.1016/j.comtox.2018.11.003
Autor:
Christina L. Gersch, Thomas L. Gonzalez, Jiantao Hu, Jose M. Larios, Siqi Sun, Wadie David, Shaomeng Wang, Daniel F. Hayes, Molly Hancock, James M. Rae
Publikováno v:
Breast cancer research and treatment. 180(3)
In the original publication of the article, the spelling of the sixth author's given name was incorrect. The corrected author name should read as "Wadie David". The original article has been corrected.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cbbfb4dce0ddbec20000cb07531392
https://pubmed.ncbi.nlm.nih.gov/32067153
https://pubmed.ncbi.nlm.nih.gov/32067153
Autor:
Thomas L. Gonzalez, Yassine Rechoum, Cristian Coarfa, Sarah Herzog, David Edwards, Hangqing Lin, Tasneem Bawa-Khalfe, Nancy L. Weigel, Sandra L. Grimm, Suzanne A. W. Fuqua, Amanda Beyer, Guowei Gu, Basil Paul, Ralf Kittler
Publikováno v:
Cancer Research. 81:PD8-09
Background: Recurrences are delayed for years with endocrine therapy (ET), but resistance ultimately evolves with the development of ER+ metastatic breast cancer (MBC). ESR1 mutations are acquired in MBC undergoing ET in about 20-40% of patients. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0428721074d8d44b45b5073d340f3411
https://doi.org/10.1158/1538-7445.sabcs20-pd8-09
https://doi.org/10.1158/1538-7445.sabcs20-pd8-09
Autor:
Shaomeng Wang, James M. Rae, Daniel F. Hayes, Thomas L. Gonzalez, Christina L. Gersch, Molly Hancock, Jose M. Larios, Jiantao Hu, Wadie David, Siqi Sun
Publikováno v:
Breast cancer research and treatment. 180(3)
Studies have identified several estrogen receptor α (ERα) ligand-binding domain (LBD) somatic mutations in endocrine therapy resistant, metastatic ER-positive breast cancers. The most common mutations, Tyr537Ser (Y537S) and Asp538Gly (D538G), are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fff5a9731aebead93d3287c7048dde
https://pubmed.ncbi.nlm.nih.gov/32180072
https://pubmed.ncbi.nlm.nih.gov/32180072
Autor:
Michael D. Johnson, Thomas L. Gonzalez, Christina L. Gersch, James M. Rae, Rudy J. Richardson, Rebecca K. Moos, Holger M. Koch
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 164(1)
Two oxidized metabolites of n-butylparaben (BuP) and iso-butylparaben (IsoBuP) discovered in human urine samples exhibit structural similarity to endogenous estrogens. We hypothesized that these metabolites bind to the human estrogen receptor (ER) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e582498be3d16db33f641139c03758
https://pubmed.ncbi.nlm.nih.gov/29945225
https://pubmed.ncbi.nlm.nih.gov/29945225