Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Thomas L. Flott"'
1
Akademický článek
Sustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated With Mortality and Protein Markers of the Host Response
Autor: Theodore S. Jennaro, PharmD, Michael A. Puskarich, MD, MS, Charles R. Evans, PhD, Alla Karnovsky, PhD, Thomas L. Flott, BA, Laura A. McLellan, BSc, Alan E. Jones, MD, Kathleen A. Stringer, PharmD
Publikováno v: Critical Care Explorations, Vol 5, Iss 4, p e0881 (2023)
OBJECTIVES:. Perturbed host metabolism is increasingly recognized as a pillar of sepsis pathogenesis, yet the dynamic alterations in metabolism and its relationship to other components of the host response remain incompletely understood. We sought to
Externí odkaz: https://doaj.org/article/418cd2c200b944379f9e41ea174c4400
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2
Akademický článek
Pharmacometabolomics identifies candidate predictor metabolites of an L‐carnitine treatment mortality benefit in septic shock
Autor: Michael A. Puskarich, Theodore S. Jennaro, Christopher E. Gillies, Charles R. Evans, Alla Karnovsky, Cora E. McHugh, Thomas L. Flott, Alan E. Jones, Kathleen A. Stringer, for the RACE Investigators
Publikováno v: Clinical and Translational Science, Vol 14, Iss 6, Pp 2288-2299 (2021)
Abstract Sepsis‐induced metabolic dysfunction contributes to organ failure and death. L‐carnitine has shown promise for septic shock, but a recent phase II study of patients with vasopressor‐dependent septic shock demonstrated a non‐significa
Externí odkaz: https://doaj.org/article/6ce1ffd631774c4e9df4a19cf077f90d
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3
Akademický článek
A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures
Autor: Mohamad H. Tiba, Brendan M. McCracken, Danielle C. Leander, Carmen I. Colmenero, Jean A. Nemzek, Michael W. Sjoding, Kristine E. Konopka, Thomas L. Flott, J. Scott VanEpps, Rodney C. Daniels, Kevin R. Ward, Kathleen A. Stringer, Robert P. Dickson
Publikováno v: Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
Abstract To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a hig
Externí odkaz: https://doaj.org/article/1b91814ffa9b403dbb4425a4d558dacb
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4
Akademický článek
Rapid, Reproducible, Quantifiable NMR Metabolomics: Methanol and Methanol: Chloroform Precipitation for Removal of Macromolecules in Serum and Whole Blood
Autor: Cora E. McHugh, Thomas L. Flott, Casey R. Schooff, Zyad Smiley, Michael A. Puskarich, Daniel D. Myers, John G. Younger, Alan E. Jones, Kathleen A. Stringer
Publikováno v: Metabolites, Vol 8, Iss 4, p 93 (2018)
Background: Though blood is an excellent biofluid for metabolomics, proteins and lipids present in blood can interfere with 1d-1H NMR spectra and disrupt quantification of metabolites. Here, we present effective macromolecule removal strategies for s
Externí odkaz: https://doaj.org/article/b995de571dbb43f7848601a638451310
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5
Pharmacometabolomics identifies candidate predictor metabolites of an L‐carnitine treatment mortality benefit in septic shock
Autor: Alla Karnovsky, Alan E. Jones, Cora McHugh, Thomas L. Flott, Christopher E. Gillies, Charles R. Evans, Michael A. Puskarich, Kathleen A. Stringer, Theodore S. Jennaro, Race Trial Investigators
Publikováno v: Clinical and Translational Science, Vol 14, Iss 6, Pp 2288-2299 (2021)
Clinical and Translational Science
Sepsis‐induced metabolic dysfunction contributes to organ failure and death. L‐carnitine has shown promise for septic shock, but a recent phase II study of patients with vasopressor‐dependent septic shock demonstrated a non‐significant reduct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edab4cd04a941acffc3c754d56c2779
https://doi.org/10.1111/cts.13088
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6
Serum Levels of Branched Chain Amino Acids Predict Duration of Cardiovascular Organ Failure in Septic Shock
Autor: Alan E. Jones, Thomas L. Flott, Alla Karnovsky, Race Trial Investigators, Michael A. Puskarich, Kathleen A. Stringer, Cora McHugh
Publikováno v: Shock
Background Sepsis shifts cardiac metabolic fuel preference and this disruption may have implications for cardiovascular function. A greater understanding of the role of metabolism in the development and persistence of cardiovascular failure in sepsis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bee2e5cd5ff3b5910c065969136dc18
https://europepmc.org/articles/PMC8089113/
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7
A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures
Autor: Jean A. Nemzek, Mohamad H. Tiba, Thomas L. Flott, Danielle C. Leander, Robert P. Dickson, Kathleen A. Stringer, Rodney C. Daniels, Brendan M. McCracken, Kristine E. Konopka, Carmen I. Colmenero, Kevin R. Ward, J. Scott VanEpps, Michael W. Sjoding
Publikováno v: Physiological Reports
Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a high‐fidel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc45382122e0f8fc976c5174f6e3c62
https://doi.org/10.14814/phy2.14871
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8
Pharmacometabolomics Identifies Candidate Predictor Metabolites of an L-carnitine Treatment Mortality Benefit in Septic Shock
Autor: Alan E. Jones, Thomas L. Flott, Cora McHugh, Alla Karnovsky, Charles R. Evans, Theodore S. Jennaro, Michael A. Puskarich, Christopher E. Gillies, Kathleen A. Stringer
BackgroundSepsis-induced metabolic dysfunction contributes to organ failure and death. L-carnitine has shown promise for septic shock, but a recent study demonstrated a non-significant reduction in mortality.MethodsA pharmacometabolomics study of pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f94cabc365ed4f247c255f650d4688d2
https://doi.org/10.1101/2021.01.28.21250687
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