Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thomas L. Avery"'
Publikováno v:
Journal of Medicinal Chemistry. 37:177-183
A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated for their antileukemic activity in mice. NaH-mediated alkylation of 6-chloropurine (4) and 2-amino-6-chloropurine (5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f7f09196ead8610f8686c9724d9589
https://doi.org/10.1021/jm00027a022
https://doi.org/10.1021/jm00027a022
Publikováno v:
ChemInform. 25
A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated for their antileukemic activity in mice. NaH-mediated alkylation of 6-chloropurine (4) and 2-amino-6-chloropurine (5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35cde0ab60e10d204fbbb2d0ae2b8b35
https://doi.org/10.1002/chin.199417239
https://doi.org/10.1002/chin.199417239
Autor:
Thomas L. Avery, Naeem B. Hanna, Steven B. Larson, Rick Avery Finch, Donald F. Smee, Ganapathi R. Revankar, K. Ramasamy, Roland K. Robins
Publikováno v:
Journal of Heterocyclic Chemistry. 27:909-918
2′-Deoxyribofuranosyl and arabinofuranosyl nucleosides of certain purine-6-sulfenamides, sulfinamides and sulfonamides have been prepared by sequential amination and controlled oxidation of the corresponding 6-thiopurine nucleosides, and evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a23fbba47895c3e4b9a08c45b7067261
https://doi.org/10.1002/jhet.5570270417
https://doi.org/10.1002/jhet.5570270417
Autor:
Rick Avery Finch, Roland K. Robins, Thomas L. Avery, Karen M. Vasquez, Ganapathi R. Revankar, Naeem B. Hanna
Publikováno v:
Cancer Letters. 50:63-70
Preclinical investigations in vivo revealed unexpected differences in the biological characteristics of 2-amino-9-beta-D-ribofuranosylpurine-6-sulfenamide (sulfenosine, 1) and 2-amino-9-beta-D-ribofuranosylpurine-6-sulfonamide (sulfonosine, 2), two n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3b86ad31f1bef463bee20d220b45ae
https://doi.org/10.1016/0304-3835(90)90180-6
https://doi.org/10.1016/0304-3835(90)90180-6
Publikováno v:
Journal of Medicinal Chemistry. 33:572-576
Glycosylation of 1,2,4 lambda 3-diazaphosphole (4) under Lewis acid catalyzed conditions gave 1-alpha-D-ribofuranosyl-1,2,4 lambda 3-diazaphosphole (5) as the only product. Ethyl 1,2,4 lambda 3-diazaphosphole-3-carboxylate (10) was synthesized by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865d55bcb16627d78fd5782186747b12
https://doi.org/10.1021/jm00164a016
https://doi.org/10.1021/jm00164a016
Autor:
Naeem B. Hanna, Thomas L. Avery, Steven B. Larson, Arthur F. Lewis, Nobutaka Imamura, Roland K. Robins, Rick Avery Finch, Ganapathi R. Revankar
Publikováno v:
Journal of Medicinal Chemistry. 33:121-128
A number of 6-sulfenamide, 6-sulfinamide, and 6-sulfonamide derivatives of 2-aminopurine and certain related purine ribonucleosides have been synthesized and evaluated for antileukemic activity in mice. Amination of 6-mercaptopurine ribonucleoside (7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b55f7d81fc3e2733246a4c019f1c219
https://doi.org/10.1021/jm00163a020
https://doi.org/10.1021/jm00163a020
Autor:
Thomas L. Avery, Boanerges Rubalcava, Roland K. Robins, Steven S. Matsumoto, Howard B. Cottam, Weldon B. Jolley, Emmanuel A. Ojo-Amaize
Publikováno v:
Immunology Letters. 23:173-178
The capacity of certain guanine ribonucleosides (modified at the 7 and/or 8 positions) to enhance the respiratory burst of murine peritoneal phagocytes was evaluated. The results show that 8-mercaptoguanosine, 8-bromoguanosine, 7-methyl-8-oxoguanosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef71fe79983d4f281e2335f6d9e626f
https://doi.org/10.1016/0165-2478(90)90187-u
https://doi.org/10.1016/0165-2478(90)90187-u
Publikováno v:
Anticancer Drug Discovery and Development: Natural Products and New Molecular Models ISBN: 9781461361183
The last 15 years have seen a virtual explosion in knowledge of cancer at the molecular level. Major efforts in the area of molecular genetics were stimulated by a study of viral oncogenes (1) and have centered around the activation of proto-oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4189652dd370a104489e261dcd267c13
https://doi.org/10.1007/978-1-4615-2610-0_9
https://doi.org/10.1007/978-1-4615-2610-0_9
Autor:
Thomas L. Avery, Ganapathi R. Revankar, Rick Avery Finch, Roland K. Robins, Nobutaka Imamura, Naeem B. Hanna, K. Ramasamy
Publikováno v:
ChemInform. 21
7-Deaza (pyrrolo[2,3-d]pyrimidine) and 3-deaza (imidazo[4,5-c]pyridine) congeners of sulfenosine (5a and 9), sulfinosine (6a and 10), and sulfonosine (7a) have been prepared and evaluated for their antileukemic activity in mice. Amination of 2-amino-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176663a58b439224025d5edac676379c
https://doi.org/10.1002/chin.199048281
https://doi.org/10.1002/chin.199048281
Autor:
Rick Avery Finch, Thomas L. Avery, Ganapathi R. Revankar, Roland K. Robins, Steven B. Larson, K. Ramasamy, Naeem B. Hanna, Donald F. Smee
Publikováno v:
ChemInform. 21
2′-Deoxyribofuranosyl and arabinofuranosyl nucleosides of certain purine-6-sulfenamides, sulfinamides and sulfonamides have been prepared by sequential amination and controlled oxidation of the corresponding 6-thiopurine nucleosides, and evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb3338b35cbb78ef6d6917cf54eb8cca
https://doi.org/10.1002/chin.199047250
https://doi.org/10.1002/chin.199047250