Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Thomas L Vaughan"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008961 (2021)
Patterns of cancer incidence, viewed over extended time periods, reveal important aspects of multistage carcinogenesis. Here we show how a multistage clonal expansion (MSCE) model for cancer can be harnessed to identify biological processes that shap
Externí odkaz:
https://doaj.org/article/933bcd9832fc4c53bfa8ba5520dd0f72
Autor:
Matthew F Buas, Lynn Onstad, David M Levine, Harvey A Risch, Wong-Ho Chow, Geoffrey Liu, Rebecca C Fitzgerald, Leslie Bernstein, Weimin Ye, Nigel C Bird, Yvonne Romero, Alan G Casson, Douglas A Corley, Nicholas J Shaheen, Anna H Wu, Marilie D Gammon, Brian J Reid, Laura J Hardie, Ulrike Peters, David C Whiteman, Thomas L Vaughan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128617 (2015)
Incidence of esophageal adenocarcinoma (EA) has increased substantially in recent decades. Multiple risk factors have been identified for EA and its precursor, Barrett's esophagus (BE), such as reflux, European ancestry, male sex, obesity, and tobacc
Externí odkaz:
https://doaj.org/article/075fc38fcef04c84b2ed178bd1f2c3ac
Autor:
Alevtina Gall, Jutta Fero, Connor McCoy, Brian C Claywell, Carissa A Sanchez, Patricia L Blount, Xiaohong Li, Thomas L Vaughan, Frederick A Matsen, Brian J Reid, Nina R Salama
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129055 (2015)
The incidence of esophageal adenocarcinoma (EAC) has increased nearly five-fold over the last four decades in the United States. Barrett's esophagus, the replacement of the normal squamous epithelial lining with a mucus-secreting columnar epithelium,
Externí odkaz:
https://doaj.org/article/39218d5243c1493db7eb27a89f082c28
Autor:
Katarina Lagergren, Weronica E Ek, David Levine, Wong-Ho Chow, Leslie Bernstein, Alan G Casson, Harvey A Risch, Nicholas J Shaheen, Nigel C Bird, Brian J Reid, Douglas A Corley, Laura J Hardie, Anna H Wu, Rebecca C Fitzgerald, Paul Pharoah, Carlos Caldas, Yvonne Romero, Thomas L Vaughan, Stuart MacGregor, David Whiteman, Lars Westberg, Olof Nyren, Jesper Lagergren
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138738 (2015)
The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett's oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or oxytocin, might contribute.This genetic-epidemiological study pooled 14 studies from three conti
Externí odkaz:
https://doaj.org/article/2c4790d40a374002b61e524278d50613
Autor:
Michael B Cook, Douglas A Corley, Liam J Murray, Linda M Liao, Farin Kamangar, Weimin Ye, Marilie D Gammon, Harvey A Risch, Alan G Casson, Neal D Freedman, Wong-Ho Chow, Anna H Wu, Leslie Bernstein, Olof Nyrén, Nirmala Pandeya, David C Whiteman, Thomas L Vaughan
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103508 (2014)
Previous studies have evidenced an association between gastroesophageal reflux and esophageal adenocarcinoma (EA). It is unknown to what extent these associations vary by population, age, sex, body mass index, and cigarette smoking, or whether durati
Externí odkaz:
https://doaj.org/article/17c9c251bcb142808d10efd9761c6eb7
Autor:
Rumen L Kostadinov, Mary K Kuhner, Xiaohong Li, Carissa A Sanchez, Patricia C Galipeau, Thomas G Paulson, Cassandra L Sather, Amitabh Srivastava, Robert D Odze, Patricia L Blount, Thomas L Vaughan, Brian J Reid, Carlo C Maley
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003553 (2013)
Cancer is considered an outcome of decades-long clonal evolution fueled by acquisition of somatic genomic abnormalities (SGAs). Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce cancer risk, including risk of progression from B
Externí odkaz:
https://doaj.org/article/50cc59ac550640b9badd6fb2ddfa1851
Autor:
Sheetal Hardikar, Lynn Onstad, Patricia L Blount, Robert D Odze, Brian J Reid, Thomas L Vaughan
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52192 (2013)
Esophageal adenocarcinoma (EA) incidence in many developed countries has increased dramatically over four decades, while survival remains poor. Persons with Barrett's esophagus (BE), who experience substantially elevated EA risk, are typically follow
Externí odkaz:
https://doaj.org/article/f5f2455e999546caa29bfc7d674bc4fc
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59709 (2013)
Werner syndrome (WS) is an autosomal recessive genetic instability and progeroid ('premature aging') syndrome which is associated with an elevated risk of cancer.Our study objectives were to characterize the spectrum of neoplasia in WS using a well-d
Externí odkaz:
https://doaj.org/article/67dc8b2aed6c4d2284095f7574e5ce6a
Autor:
Yumie Takata, Alan R Kristal, Regina M Santella, Irena B King, David J Duggan, Johanna W Lampe, Margaret P Rayman, Patricia L Blount, Brian J Reid, Thomas L Vaughan, Ulrike Peters
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38612 (2012)
Clinical trials have suggested a protective effect of selenium supplementation on the risk of esophageal cancer, which may be mediated through the antioxidant activity of selenoenzymes. We investigated whether serum selenium concentrations, selenoenz
Externí odkaz:
https://doaj.org/article/40ef4dfb33d04cfaa826fe44d26e6963
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 2, p e1001087 (2011)
Aside from primary prevention, early detection remains the most effective way to decrease mortality associated with the majority of solid cancers. Previous cancer screening models are largely based on classification of at-risk populations into three
Externí odkaz:
https://doaj.org/article/99902de792854f98bcf1148ea520ce96