A guide to the BRAIN Initiative Cell Census Network data ecosystem.

Autor: Michael Hawrylycz, Maryann E Martone, Giorgio A Ascoli, Jan G Bjaalie, Hong-Wei Dong, Satrajit S Ghosh, Jesse Gillis, Ronna Hertzano, David R Haynor, Patrick R Hof, Yongsoo Kim, Ed Lein, Yufeng Liu, Jeremy A Miller, Partha P Mitra, Eran Mukamel, Lydia Ng, David Osumi-Sutherland, Hanchuan Peng, Patrick L Ray, Raymond Sanchez, Aviv Regev, Alex Ropelewski, Richard H Scheuermann, Shawn Zheng Kai Tan, Carol L Thompson, Timothy Tickle, Hagen Tilgner, Merina Varghese, Brock Wester, Owen White, Hongkui Zeng, Brian Aevermann, David Allemang, Seth Ament, Thomas L Athey, Cody Baker, Katherine S Baker, Pamela M Baker, Anita Bandrowski, Samik Banerjee, Prajal Bishwakarma, Ambrose Carr, Min Chen, Roni Choudhury, Jonah Cool, Heather Creasy, Florence D'Orazi, Kylee Degatano, Benjamin Dichter, Song-Lin Ding, Tim Dolbeare, Joseph R Ecker, Rongxin Fang, Jean-Christophe Fillion-Robin, Timothy P Fliss, James Gee, Tom Gillespie, Nathan Gouwens, Guo-Qiang Zhang, Yaroslav O Halchenko, Nomi L Harris, Brian R Herb, Houri Hintiryan, Gregory Hood, Sam Horvath, Bingxing Huo, Dorota Jarecka, Shengdian Jiang, Farzaneh Khajouei, Elizabeth A Kiernan, Huseyin Kir, Lauren Kruse, Changkyu Lee, Boudewijn Lelieveldt, Yang Li, Hanqing Liu, Lijuan Liu, Anup Markuhar, James Mathews, Kaylee L Mathews, Chris Mezias, Michael I Miller, Tyler Mollenkopf, Shoaib Mufti, Christopher J Mungall, Joshua Orvis, Maja A Puchades, Lei Qu, Joseph P Receveur, Bing Ren, Nathan Sjoquist, Brian Staats, Daniel Tward, Cindy T J van Velthoven, Quanxin Wang, Fangming Xie, Hua Xu, Zizhen Yao, Zhixi Yun, Yun Renee Zhang, W Jim Zheng, Brian Zingg

Publikováno v: PLoS Biology, Vol 21, Iss 6, p e3002133 (2023)

Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function of cell types in the brain. Classification of neurons is also essential to manipulate cell typ

Externí odkaz: https://doaj.org/article/5683e726eb424a3187544a44691a1d0f

Fitting Splines to Axonal Arbors Quantifies Relationship Between Branch Order and Geometry

Autor: Thomas L. Athey, Jacopo Teneggi, Joshua T. Vogelstein, Daniel J. Tward, Ulrich Mueller, Michael I. Miller

Publikováno v: Frontiers in Neuroinformatics, Vol 15 (2021)

Neuromorphology is crucial to identifying neuronal subtypes and understanding learning. It is also implicated in neurological disease. However, standard morphological analysis focuses on macroscopic features such as branching frequency and connectivi

Externí odkaz: https://doaj.org/article/ae058ddd63e941ffb7babe0ee99455a3

Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling

Autor: S. Michaela Rikard, Thomas L. Athey, Anders R. Nelson, Steven L. M. Christiansen, Jia-Jye Lee, Jeffrey W. Holmes, Shayn M. Peirce, Jeffrey J. Saucerman

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Wound healing and fibrosis following myocardial infarction (MI) is a dynamic process involving many cell types, extracellular matrix (ECM), and inflammatory cues. As both incidence and survival rates for MI increase, management of post-MI recovery an

Externí odkaz: https://doaj.org/article/0a2f19745219486398d59b1542d70ba7

Is Neuroscience FAIR? A Call for Collaborative Standardisation of Neuroscience Data

Autor: Jean-Baptiste Poline, David N. Kennedy, Friedrich T. Sommer, Giorgio A. Ascoli, David C. Van Essen, Adam R. Ferguson, Jeffrey S. Grethe, Michael J. Hawrylycz, Paul M. Thompson, Russell A. Poldrack, Satrajit S. Ghosh, David B. Keator, Thomas L. Athey, Joshua T. Vogelstein, Helen S. Mayberg, Maryann E. Martone

Publikováno v: Neuroinformatics, vol 20, iss 2

In this perspective article, we consider the critical issue of data and other research object standardisation and, specifically, how international collaboration, and organizations such as the International Neuroinformatics Coordinating Facility (INCF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57511d212776a6500ec044053632c1f3
https://doi.org/10.1007/s12021-021-09557-0

A 7 Tesla Amygdalar-Hippocampal Shape Analysis of Lithium Response in Bipolar Disorder

Autor: Thomas L. Athey, Can Ceritoglu, Daniel J. Tward, Kwame S. Kutten, J. Raymond DePaulo, Kara Glazer, Fernando S. Goes, John R. Kelsoe, Francis Mondimore, Caroline M. Nievergelt, Kelly Rootes-Murdy, Peter P. Zandi, J. Tilak Ratnanather, Pamela B. Mahon

Publikováno v: Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 12 (2021)

Research to discover clinically useful predictors of lithium response in patients with bipolar disorder has largely found them to be elusive. We demonstrate here that detailed neuroimaging may have the potential to fill this important gap in mood dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba288d5c42e376ef2beceec0cfaa4ed
https://pubmed.ncbi.nlm.nih.gov/33664682