Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Thomas L, Edwards"'
Autor:
Alexis Ceecee Britten-Jones, Joshua Schultz, Heather G. Mack, Lisa S. Kearns, Aamira J. Huq, Jonathan B. Ruddle, David A. Mackey, Alex W. Hewitt, Thomas L. Edwards, Lauren N. Ayton
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract This study evaluated patient experiences with genetic testing for inherited retinal diseases (IRDs) and the association between underlying knowledge, testing outcomes, and the perceived value of the results. An online survey was distributed
Externí odkaz:
https://doaj.org/article/c77e2b459ac246a794c86c5b38e23017
Autor:
Jiang-Hui Wang, Grace E. Lidgerwood, Maciej Daniszewski, Monica L. Hu, Georgina E. Roberts, Raymond C. B. Wong, Sandy S. C. Hung, Michelle E. McClements, Alex W. Hewitt, Alice Pébay, Doron G. Hickey, Thomas L. Edwards
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Bietti crystalline dystrophy (BCD) is an inherited retinal disease (IRD) caused by mutations in the CYP4V2 gene. It is a relatively common cause of IRD in east Asia. A number of features of this disease make it highly amenable to gene supple
Externí odkaz:
https://doaj.org/article/92f20941b1a14782b8b22261c0464675
Autor:
Daniel Urrutia-Cabrera, Roxanne Hsiang-Chi Liou, Jiang-Hui Wang, Jianxiong Chan, Sandy Shen-Chi Hung, Alex W. Hewitt, Keith R. Martin, Thomas L. Edwards, Patrick Kwan, Raymond Ching-Bong Wong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The COVID-19 pandemic caused by SARS-CoV-2 has infected millions worldwide, therefore there is an urgent need to increase our diagnostic capacity to identify infected cases. Although RT-qPCR remains the gold standard for SARS-CoV-2 detection
Externí odkaz:
https://doaj.org/article/cafa6f5cd3294e629d44f28865896d6b
Autor:
Fred K Chen, Alex W Hewitt, Alan Ma, John Grigg, Keith R Martin, Robyn Jamieson, Heather G Mack, Fleur O’Hare, David Mackey, John De Roach, Alexis Ceecee Britten-Jones, Myra McGuinness, Nicole Tindill, Lauren Ayton, Anai Gonzalez Cordero, Thomas L Edwards, Gladys Ho, Michael Hogden, Anthony Kwan, Tina Lamey, Terri McLaren, Benjamin Nash, Jon Ruddle, Matthew Simunovic, Ingrid Sinnerbrink, Deepa Ajay Taranath, Jen Thompson, Jaclyn White
Publikováno v:
BMJ Open, Vol 11, Iss 6 (2021)
Introduction Voretigene neparvovec-rzyl (Luxturna) was approved by the Australian Therapeutic Goods Administration on 4 August 2020 for the treatment of biallelic mutations in the RPE65 gene, a rare cause of congenital and adult-onset retinal dystrop
Externí odkaz:
https://doaj.org/article/748c300353da46cfad1dfa7d7e12385a
Autor:
Tu Nguyen, Daniel Urrutia-Cabrera, Luozixian Wang, Jarmon G. Lees, Jiang-Hui Wang, Sandy S.C. Hung, Alex W. Hewitt, Thomas L. Edwards, Sam McLenachan, Fred K. Chen, Shiang Y. Lim, Chi D. Luu, Robyn Guymer, Raymond C.B. Wong
Publikováno v:
Aging. 15:1713-1733
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f9b4d6e8ca49d64d94824d44a4d2c35
https://doi.org/10.18632/aging.204522
https://doi.org/10.18632/aging.204522
Survey of perspectives of people with inherited retinal diseases on ocular gene therapy in Australia
Autor:
Heather G. Mack, Alexis Ceecee Britten-Jones, Myra B. McGuinness, Fred K. Chen, John R. Grigg, Robyn V. Jamieson, Thomas L. Edwards, John De Roach, Fleur O’Hare, Keith R. Martin, Lauren N. Ayton
Publikováno v:
Gene Therapy. 30:336-346
Many gene therapies are in development for treating people with inherited retinal diseases (IRD). We hypothesized that potential recipients of gene therapy would have knowledge gaps regarding treatment. We aimed to assess knowledge, attitudes, and pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::948216fe43ce929e26a5e2c099b66056
https://doi.org/10.1038/s41434-022-00364-z
https://doi.org/10.1038/s41434-022-00364-z
Publikováno v:
Clinical & Experimental Ophthalmology. 50:768-780
Emerging treatments are being developed for inherited retinal diseases, requiring a clear understanding of natural progression and a database of potential participants for clinical trials. This article describes the rationale, study design and method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ade8104ecd0491af942405e8c26ade7
https://doi.org/10.1111/ceo.14110
https://doi.org/10.1111/ceo.14110
Autor:
Robert E MacLaren, Maarten Beelen, Thijs C. M. Meenink, Thomas L Edwards, Kanmin Xue, Gerrit Naus, Jasmina Cehajic-Kapetanovic, Marc D. de Smet
Publikováno v:
American Journal of Ophthalmology. 237:104-113
Purpose To report the results of a first-in-human study using a robotic device to assist subretinal drug delivery in patients undergoing vitreoretinal surgery for macular haemorrhage. Design Double armed, randomized controlled surgical trial (Clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46336ecf32dcaf97eb00910fa11d32bb
https://doi.org/10.1016/j.ajo.2021.11.011
https://doi.org/10.1016/j.ajo.2021.11.011
Autor:
Jiang-Hui Wang, Daniel Urrutia-Cabrera, Jarmon G. Lees, Santiago Mesa Mora, Tu Nguyen, Sandy S. C. Hung, Alex W. Hewitt, Shiang Y. Lim, Thomas L. Edwards, Raymond C. B. Wong
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3417
Volume 24
Issue 4
Pages: 3417
Age-related macular degeneration (AMD) is a blinding disease characterised by dysfunction of the retinal pigmented epithelium (RPE) which culminates in disruption or loss of the neurosensory retina. Genome-wide association studies have identified >60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34c13fee6d9e678987080a1a7fba73e
Autor:
Katarina Stingl, Ruth Schippert, Karl U. Bartz-Schmidt, Dorothea Besch, Charles L. Cottriall, Thomas L. Edwards, Florian Gekeler, Udo Greppmaier, Katja Kiel, Assen Koitschev, Laura Kühlewein, Robert E. MacLaren, James D. Ramsden, Johann Roider, Albrecht Rothermel, Helmut Sachs, Greta S. Schröder, Jan Tode, Nicole Troelenberg, Eberhart Zrenner
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Purpose: We assessed the safety and efficacy of a technically advanced subretinal electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration in an interim analysis of two ongoing prospective clinical trials. The purpose of this a
Externí odkaz:
https://doaj.org/article/a36b08621b894d71b1d1c498ff334af9