Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thomas L, Deckwerth"'
Autor:
Kate C. Gillespie, Thomas L. Deckwerth, Richard A. Klinghoffer, Joseph Casalini, Joyoti Dey, Edward F. Kleinman, Sally Ditzler, Marc Grenley, Emily Beirne, Chantel P. Dixon, Angela Merrell, Connor Burns, William S. Kerwin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor resistance to chemotherapy. BCL-2 and functionally redundant counterpart, MCL-1, are frequently over-expressed in high-risk diffuse large B-cell lymphoma (DLBCL). Whil
Autor:
Richard A. Klinghoffer, Joseph Casalini, Emily J. Girard, Michael Carleton, Kyle Pedro, Thomas L. Deckwerth, Shelli M. Morris, Ilona Tretyak, Andrew D. Strand, Emily Beirne, James M. Olson, Sheng You, Derek Thirstrup, Oliver W. Press, Sally Ditzler, Korashon L. Watts, William S. Kerwin, Jason Frazier, Alicia Moreno-Gonzalez, Rajesh Chopra, Jessica A. Bertout, Joyoti Dey, Mandana Veiseh, Beryl A. Hatton, Ellen Filvaroff, Marc Grenley, Karri A. Meleo, S. Bahram Bahrami
A fundamental problem in cancer drug development is that antitumor efficacy in preclinical cancer models does not translate faithfully to patient outcomes. Much of early cancer drug discovery is performed under in vitro conditions in cell-based model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036e0944789fee2391dea23e9e214e73
https://europepmc.org/articles/PMC4770902/
https://europepmc.org/articles/PMC4770902/
Autor:
Shinichi Kitada, Jacqueline M. O'Connor, John C. Reed, Wendt Michael D, Andrew M. Petros, Alexander R. Shoemaker, Anatol Oleksijew, David J. Augeri, Craig B. Thompson, Kunzer Aaron R, Jürgen Dinges, Thomas L. Deckwerth, Stanley J. Korsmeyer, Saul H. Rosenberg, Stephen K. Tahir, Barbara A. Belli, Paul Nimmer, Baole Wang, Shi Chung Ng, Steven W. Elmore, Anthony Letai, Wang Shen, Haichao Zhang, Tilman Oltersdorf, Stephen W. Fesik, Milan Bruncko, David G. Nettesheim, Robert C. Armstrong, Michael J. Mitten, Kevin J. Tomaselli, Mary K. Joseph, Philip J. Hajduk, Chi Li
Publikováno v:
Nature. 435:677-681
Proteins in the Bcl-2 family are central regulators of programmed cell death, and members that inhibit apoptosis, such as Bcl-X(L) and Bcl-2, are overexpressed in many cancers and contribute to tumour initiation, progression and resistance to therapy
Autor:
Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described h
Autor:
Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum
Autor:
Teresa Aja, André Sauter, Donald S. Karanewsky, Markus Rudin, Rachel May, Peter R. Allegrini, Bastian Hengerer, Robert O. Sayers, Christoph Wiessner, Steve Linton, Albert Schmitz, Giorgio Rovelli, Kevin J. Tomaselli, Patricia C. Contreras, Joe C. Wu, Silvio Roggo, Kip Nalley, Lisa M. Adams, Thomas L. Deckwerth
Publikováno v:
Drug Development Research. 52:579-586
Apoptotic cell death occurs in the injured and diseased central nervous system. It is mediated by a family of caspases, which are activated by the lethal stimulus and cleave multiple protein substrates that are critical for cell viability. Previous s
Autor:
Kurt A. Jellinger, Anu Srinivasan, Thomas L. Deckwerth, Christine Stadelmann, Christian Bancher, Hans Lassmann, Wolfgang Brück
Publikováno v:
The American Journal of Pathology. 155:1459-1466
Neuronal loss is prominent in Alzheimer's disease (AD), and its mechanisms remain unresolved. Apoptotic cell death has been implicated on the basis of studies demonstrating DNA fragmentation and an up-regulation of proapoptotic proteins in the AD bra
Publikováno v:
The Journal of Neuroscience. 17:9656-9666
During development, sympathetic neurons are critically dependent on nerve growth factor (NGF) for survival. Neurons isolated from the superior cervical ganglia (SCG) of embryonic rodents and maintained for 1 weekin vitroundergo programmed cell death
Publikováno v:
Neuron. 14(2):303-315
Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor (NGF). We used this model of programmed cell death to study the mechanisms that mediate neuronal apoptosis. Cultured sympathetic neurons were injected with copper/zi
Autor:
Thomas L. Deckwerth, Eugene M. Johnson
Publikováno v:
The Journal of Cell Biology
The time course of molecular events that accompany degeneration and death after nerve growth factor (NGF) deprivation and neuroprotection by NGF and other agents was examined in cultures of NGF-dependent neonatal rat sympathetic neurons and compared