Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Thomas L, Bray"'
1
A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry
Autor: Catherine, Adam, Thomas L, Bray, Ana M, Pérez-López, Ee Hong, Tan, Belén, Rubio-Ruiz, Daniel J, Baillache, Douglas R, Houston, Mark J, Salji, Hing Y, Leung, Asier, Unciti-Broceta
Publikováno v: Journal of medicinal chemistry. 65(1)
5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and do
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbf899eb586075fab99454a4ac00bd8b
https://pubmed.ncbi.nlm.nih.gov/34979089
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2
A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo
Autor: Catherine Adam, Thomas L. Bray, Ana M. Pérez-López, Ee Hong Tan, Belén Rubio-Ruiz, Daniel J. Baillache, Douglas R. Houston, Mark J. Salji, Hing Y. Leung, Asier Unciti-Broceta
Publikováno v: Adam, C, Bray, T, Perez-Lopez, A, Tan, E H, Rubio Ruiz, B, Baillache, D, Houston, D R, Salji, M J, Leung, H Y & Unciti-Broceta, A 2022, ' A 5-FU precursor designed to evade anabolic and catabolic drug pathways and activated by Pd chemistry in vitro and in vivo ', Journal of Medicinal Chemistry, vol. 65, no. 1, pp. 552-561 . https://doi.org/10.1021/acs.jmedchem.1c01733
5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and do
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5f8ba00f4b02191c9fbb77c71335c2
https://hdl.handle.net/10668/22589
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3
Gold‐Triggered Uncaging Chemistry in Living Systems
Autor: Ana M. Pérez‐López, Belén Rubio‐Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd‐Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti‐Broceta
Publikováno v: Angewandte Chemie (International Ed. in English)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
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Perez-Lopez, A M, Rubio Ruiz, B, Sebastian, V, Hamilton, L, Adam, C, Bray, T L, Irusta, S, Brennan, P M, Lloyd-Jones, G C, Sieger, D, Santamaria, J & Unciti-Broceta, A 2017, ' Gold-Triggered Uncaging Chemistry in Living Systems ', Angewandte Chemie, vol. 129, no. 41, pp. 12722-12726 . https://doi.org/10.1002/ange.201705609
Angewandte Chemie International Edition
Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777368492edb2ffe5c079d1e7172f59e
https://doi.org/10.1002/ange.201705609
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5
Bright insights into palladium-triggered local chemotherapy
Autor: Mark Salji, Alessandro Brombin, Belén Rubio-Ruiz, Thomas L. Bray, Asier Unciti-Broceta, Laura C. A. Galbraith, E. Elizabeth Patton, Ana M. Pérez-López, Hing Y. Leung
Publikováno v: Chemical Science
Bray, T L, Salji, M, Brombin, A, Pérez-López, A M, Rubio Ruiz, B, Galbraith, L C A, Patton, E E, Leung, H Y & Unciti-Broceta, A 2018, ' Bright insights into Palladium-triggered local chemotherapy ', Chemical Science . https://doi.org/10.1039/C8SC02291G
We report fundamental insights into the validity, reliability and clinical feasibility of using heterogeneous Pd catalysts as implantable devices to accurately activate chemotherapy within a tumour.
The incorporation of transition metal catalyst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affec99a2270eb398078c6cd0942df8f
https://eprints.gla.ac.uk/166182/1/166182.pdf
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6
Bioorthogonal Uncaging of the Active Metabolite of Irinotecan by Palladium-Functionalized Microdevices
Autor: Catherine, Adam, Ana M, Pérez-López, Lloyd, Hamilton, Belén, Rubio-Ruiz, Thomas L, Bray, Dirk, Sieger, Paul M, Brennan, Asier, Unciti-Broceta
Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
SN‐38, the active metabolite of irinotecan, is released upon liver hydrolysis to mediate potent antitumor activity. Systemic exposure to SN‐38, however, also leads to serious side effects. To reduce systemic toxicity by controlling where and when
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43eced79822fd225c044d38fabe3b317
https://pubmed.ncbi.nlm.nih.gov/30187973
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7
High-Precision Photothermal Ablation Using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy
Autor: Alan Serrels, Martin Lee, Neil O. Carragher, Victor Sebastian, Martin Prieto, Asier Unciti-Broceta, Belén Rubio-Ruiz, Manuel Arruebo, Ana M. Pérez-López, Thomas L. Bray
Publikováno v: Rubio Ruiz, B, Pérez-López, A M, Bray, T L, Lee, M, Serrels, A, Prieto, M, Arruebo, M, Carragher, N O, Sebastián, V & Unciti-Broceta, A 2018, ' High-Precision Photothermal Ablation using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy ', ACS Applied Materials & Interfaces . https://doi.org/10.1021/acsami.7b17282
ACS Applied Materials & Interfaces
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Herein we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells and able to kill labelled can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07f6bd72d2818e59faee0291fb86f5c
http://zaguan.unizar.es/record/69463
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10
Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
Autor: Kevin Hestir, Amy W. Hsu, Hongbing Zhang, Aileen Zhou, Elizabeth Bosch, W. Michael Kavanaugh, Brian Wong, Lewis T. Williams, Lily Pao, Ernestine Lee, Gang Wang, Haixia Liu, Thomas L. Bray, Robert Halenbeck, Arthur Brace
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 111(44)
There are many transmembrane receptor-like proteins whose ligands have not been identified. A strategy for finding ligands when little is known about their tissue source is to screen each extracellular protein individually expressed in an array forma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52506ae0a6bfa52a22022ff08a00bf17
https://pubmed.ncbi.nlm.nih.gov/25331893
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