Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Thomas Knopfel"'
Autor:
Yuqi Liang, Junhao Liang, Chenchen Song, Mianxin Liu, Thomas Knöpfel, Pulin Gong, Changsong Zhou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The cerebral cortex has ongoing electrical activities with rich and complex patterns in space and time. Here, the authors use optical voltage imaging in mice and computational methods, relating these complexities to different levels of wakefulness.
Externí odkaz:
https://doaj.org/article/ec474d9973c14a91ae5133fe1faaf1c0
Autor:
Åsa Lina M. Jönsson, Nati Hernando, Thomas Knöpfel, Susie Mogensen, Elisabeth Bendstrup, Ole Hilberg, Jane Hvarregaard Christensen, Ulf Simonsen, Carsten A. Wagner
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-11 (2022)
Abstract Background Variants in SLC34A2 encoding the sodium-dependent phosphate transport protein 2b (NaPi-IIb) cause the rare lung disease pulmonary alveolar microlithiasis (PAM). PAM is characterised by the deposition of calcium-phosphate concretio
Externí odkaz:
https://doaj.org/article/b26c4688d07040dca763b1684c455225
Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice
Publikováno v:
eLife, Vol 12 (2023)
Coordinated peri-ripple activity in the hippocampal-neocortical network is essential for mnemonic information processing in the brain. Hippocampal ripples likely serve different functions in sleep and awake states. Thus, the corresponding neocortical
Externí odkaz:
https://doaj.org/article/924fdffa35ba468786103704aebc9906
Autor:
Bogachan Tahirbegi, Alastair J. Magness, Maria Elena Piersimoni, Xiangyu Teng, James Hooper, Yuan Guo, Thomas Knöpfel, Keith R. Willison, David R. Klug, Liming Ying
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Aggregation kinetics of proteins and peptides have been studied extensively due to their significance in many human diseases, including neurodegenerative disorders, and the roles they play in some key physiological processes. However, most of these s
Externí odkaz:
https://doaj.org/article/75ea4c38a6e541a4b5653121b314c1b0
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The serotonin (5-HT) 2A receptor is the primary molecular target of serotonergic hallucinogens, which trigger large-scale perturbations of the cortex. Our understanding of how 5-HT2A activation may cause the effects of hallucinogens has been hampered
Externí odkaz:
https://doaj.org/article/636ec90072f741e38ebece1e364bb296
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 3 (2009)
The relatively simple and highly modular circuitry of the cerebellum raised expectations decades ago that a realistic computational model of cerebellar circuit operations would be feasible, and prove insightful for unraveling cerebellar information p
Externí odkaz:
https://doaj.org/article/ff4487cf60d54a2483044b03abf05878
Second and third generation voltage-sensitive fluorescent proteins for monitoring membrane potential
Autor:
Amelie Perron, Hiroki Mutoh, Walther Akemann, Sunita Ghimire, Dimitar Dimitrov, Yuka Iwamoto, Thomas Knopfel
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 2 (2009)
Over the last decade, optical neuroimaging methods have been enriched by engineered biosensors derived from fluorescent protein (FP) reporters fused to protein detectors that convert physiological signals into changes of intrinsic FP fluorescence. Th
Externí odkaz:
https://doaj.org/article/3fa0b365a9ac4cada6dcabe5f8ded733
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c894b43df1d86e4268ffe134a7ba984e
https://doi.org/10.2139/ssrn.4088887
https://doi.org/10.2139/ssrn.4088887
Autor:
Thomas Knopfel, Edward S. Boyden
Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Cholinergic modulation of brain activity is fundamental for awareness and conscious sensorimotor behaviours, but deciphering the timing and significance of acetylcholine actions for these behaviours is challenging. The widespread nature of c
Externí odkaz:
https://doaj.org/article/73730454205d4df7a402ff43b1062d0f