Pd-catalyzed decarboxylative Heck vinylation of 2-nitrobenzoates in the presence of CuF2

Autor: Lukas J. Gooßen, Bettina Zimmermann, Thomas Knauber

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 43 (2010)

A new protocol for the decarboxylative Heck vinylation of benzoic acids is disclosed. In the presence of a catalyst system generated in situ from Pd(OAc)2 (2 mol %), CuF2 (2 equiv), and benzoquinone (0.5 equiv) in NMP, a wide range of olefins were co

Externí odkaz: https://doaj.org/article/7af280a9c43a4768b025fd7dbf914b92

A Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids

Autor: Tiffany Q. Chen, P. Scott Pedersen, Nathan W. Dow, Remi Fayad, Cory E. Hauke, Michael C. Rosko, Evgeny O. Danilov, David C. Blakemore, Anne-Marie Dechert-Schmitt, Thomas Knauber, Felix N. Castellano, David W. C. MacMillan

Publikováno v: J Am Chem Soc

Aryl halides are a fundamental motif in synthetic chemistry, playing a critical role in metal-mediated cross-coupling reactions and serving as important scaffolds in drug discovery. Although thermal decarboxylative functionalization of aryl carboxyli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0cecd22147dd319a9bc80690ff9fed
https://pubmed.ncbi.nlm.nih.gov/35486956

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

Autor: Natan J. W. Straathof, Thomas Knauber, Laura Buglioni, Véronique Gouverneur, Christopher W. am Ende, Claudio F. Meyer, Andrés A. Trabanco, Jeroen B. I. Sap, Timothy Noël, Christophe Genicot, Maurice Médebielle

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2020, 142 (20), pp.9181-9187. ⟨10.1021/jacs.0c03881⟩
Journal of the American Chemical Society, 142(20), 9181-9187. American Chemical Society

Molecular editing such as insertion, deletion, and single atom exchange in highly functionalized compounds is an aspirational goal for all chemists. Here, we disclose a photoredox protocol for the replacement of a single fluorine atom with hydrogen i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b50cda0eabdf7a5b3e85f17bf72e0a2
http://europepmc.org/articles/PMC7304874

Photons as a 21st century reagent

Autor: Thomas Knauber, François Lévesque, Eric G. Moschetta, Lee Edwards, Holly E. Bonfield, Flavien Susanne

Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-4 (2020)

A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68488352f71b80a7cb3aabde6fe52031
http://europepmc.org/articles/PMC7004975

Ru/Ni Dual Catalytic Desulfinative Photoredox Csp2–Csp3 Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides

Autor: Jinshan Michael Chen, Matthew R. Reese, Christopher John Helal, Ramalakshmi Yegna Chandrasekaran, Neal W. Sach, Thomas Knauber, Joseph W. Tucker, Danica A. Rankic

Publikováno v: Organic Letters. 19:6566-6569

A mild Ru/Ni dual catalytic desulfinative photoredox Csp2–Csp3 cross-coupling reaction of alkyl sulfinate salts with aryl halides has been developed. The optimized catalyst system, consisting of Ru(bpy)3Cl2, Ni(COD)2, and DBU, smoothly mediates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3881dce55862e4f3475368c225f0ef1c
https://doi.org/10.1021/acs.orglett.7b03280