Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Thomas Kluz"'
Autor:
Alex H. Li, Sun Young Park, Peiwei Li, Chaoting Zhou, Thomas Kluz, Jingxia Li, Max Costa, Hong Sun
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1783 (2024)
Bladder cancer, the most common malignancy of the urinary tract, has a poor overall survival rate when the tumor becomes muscle invasive. The discovery and evaluation of new alternative medications targeting high-grade muscle invasive bladder cancer
Externí odkaz:
https://doaj.org/article/59d91af8793547769f84e904376f3c48
Autor:
Sung-Hyun Park, Yuting Lu, Yongzhao Shao, Colette Prophete, Lori Horton, Maureen Sisco, Hyun-Wook Lee, Thomas Kluz, Hong Sun, Max Costa, Judith Zelikoff, Lung-Chi Chen, Mitchell D Cohen
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0257241 (2021)
Isoflurane (ISO) is a widely used inhalation anesthetic in experiments with rodents and humans during surgery. Though ISO has not been reported to impart long-lasting side effects, it is unknown if ISO can influence gene regulation in certain tissues
Externí odkaz:
https://doaj.org/article/448ef4967a854807963659a33b140da9
Autor:
Danqi Chen, Qiao Yi Chen, Zhenjia Wang, Yusha Zhu, Thomas Kluz, Wuwei Tan, Jinquan Li, Feng Wu, Lei Fang, Xiaoru Zhang, Rongquan He, Steven Shen, Hong Sun, Chongzhi Zang, Chunyuan Jin, Max Costa
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101518- (2020)
Summary: Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3′ end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histo
Externí odkaz:
https://doaj.org/article/c645918cfe0f4919af8a6e2d5eff9a86
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155002 (2016)
Cadmium is a carcinogenic metal, the mechanisms of which are not fully understood. In this study, human bronchial epithelial cells were transformed with sub-toxic doses of cadmium (0.01, 0.05, and 0.1 μM) and transformed clones were characterized fo
Externí odkaz:
https://doaj.org/article/2e043f49e14349989c3adb651a96a41a
Solar Simulated Ultraviolet Radiation Induces Global Histone Hypoacetylation in Human Keratinocytes.
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150175 (2016)
Ultraviolet radiation (UVR) from sunlight is the primary effector of skin DNA damage. Chromatin remodeling and histone post-translational modification (PTM) are critical factors in repairing DNA damage and maintaining genomic integrity, however, the
Externí odkaz:
https://doaj.org/article/23b6eda527c64a7c9b764aa13fda4a6d
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157317 (2016)
The environmental and occupational carcinogen Hexavalent Chromium (Cr(VI)) has been shown to cause lung cancer in humans when inhaled. In spite of a considerable research effort, the mechanisms of Cr(VI)-induced carcinogenesis remain largely unknown.
Externí odkaz:
https://doaj.org/article/0a023101f57749738017daaed137457a
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17982 (2011)
Hexavalent chromium [Cr(VI)] is a potent human carcinogen. Occupational exposure has been associated with increased risk of respiratory cancer. Multiple mechanisms have been shown to contribute to Cr(VI) induced carcinogenesis, including DNA damage,
Externí odkaz:
https://doaj.org/article/3efb7cebe5864f8181989e038f84c05f
Autor:
Kam-Meng Tchou-Wong, Kathrin Kiok, Zuojian Tang, Thomas Kluz, Adriana Arita, Phillip R Smith, Stuart Brown, Max Costa
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17728 (2011)
Occupational exposure to nickel compounds has been associated with lung and nasal cancers. We have previously shown that exposure of the human lung adenocarcinoma A549 cells to NiCl(2) for 24 hr significantly increased global levels of trimethylated
Externí odkaz:
https://doaj.org/article/09e373286f1e4d7b8e79546985e6a345
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22764 (2011)
Liprin-α4 was strongly induced following nickel (II) chloride exposure in a variety of cell types including BEAS-2B, A549, BEP2D and BL41 cells. Liprin-α4, a member of the Liprin alpha family, has seven isoforms but only three of these variants wer
Externí odkaz:
https://doaj.org/article/e228b0c27ac24e2e8a17c10f5362f1be
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8531 (2009)
Nickel (Ni) compounds have been found to cause cancer in humans and animal models and to transform cells in culture. At least part of this effect is mediated by stabilization of hypoxia inducible factor (HIF1a) and activating its downstream signaling
Externí odkaz:
https://doaj.org/article/56abe808872a4a9db0d20cd560ad56ec