Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Thomas Klabunde"'
Autor:
Francesca Sacco, Sean J. Humphrey, Jürgen Cox, Marcel Mischnik, Anke Schulte, Thomas Klabunde, Matthias Schäfer, Matthias Mann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Dysfunction in insulin secretion is a main driver of type 2 diabetes development. Here the authors monitor phosphoproteome modulation in cells stimulated with glucose and treated with drugs affecting glucose-mediated insulin secretion to reveal phosp
Externí odkaz:
https://doaj.org/article/3361cb00241f44baab7bbae3776530c4
Autor:
Chiara Dalla Man, Michela Riz, Roberto Visentin, Claudio Cobelli, Thomas Klabunde, Michele Schiavon, Britta Göbel
Publikováno v:
Diabetes, Obesity & Metabolism
Aim To gain further insights into the efficacy of SAR425899, a dual glucagon‐like peptide‐1/glucagon receptor agonist, by providing direct comparison with the glucagon‐like peptide‐1 receptor agonist, liraglutide, in terms of key outcomes of
Autor:
Chiara Dalla Man, Roberto Visentin, Jochen Sieber, Clemens Giegerich, Claudio Cobelli, Michele Schiavon, Thomas Klabunde
Publikováno v:
Diabetes Technology & Therapeutics
Background: Second-generation long-acting insulin glargine 300 U/mL (Gla-300) and degludec 100 U/mL (Deg-100) provide novel basal insulin therapies for the treatment of type 1 diabetes (T1D). Both offer a flatter pharmacokinetic (PK) profile than the
Autor:
Chiara Dalla Man, Claudio Cobelli, Roberto Visentin, Clemens Giegerich, Thomas Klabunde, Michele Schiavon
Publikováno v:
IEEE Transactions on Biomedical Engineering. 67:624-631
Objective: Subcutaneous (sc) administration of long-acting insulin analogs is often employed in multiple daily injection (MDI) therapy of type 1 diabetes (T1D) to cover patient's basal insulin needs. Among these, insulin glargine 100 U/mL (Gla-100) a
Autor:
Thomas Klabunde, Clemens Giegerich
Background and objectiveIn March 2020 the SARS-CoV-2 outbreak has been declared as global pandemic. Most countries have implemented numerous “social distancing” measures in order to limit its transmission and control the outbreak. This study aims
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227814b4a029e4d2aa1531fb62737a82
Autor:
Chiara Dalla Man, Roberto Visentin, Thomas Klabunde, Michele Schiavon, Claudio Cobelli, Michela Riz, Britta Göbel
Aim To evaluate the change in insulin sensitivity, β-cell function and glucose absorption after 28 days of treatment with high and low doses of SAR425899, a novel dual glucagon-like peptide-1 receptor/glucagon receptor agonist, versus placebo. Mater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529a67e7363ddbb1bdb42653537f682d
http://hdl.handle.net/11577/3332939
http://hdl.handle.net/11577/3332939
Autor:
Roberto Visentin, Claudio Cobelli, Chiara Dalla Man, Thomas Klabunde, Clemens Giegerich, Michele Schiavon
Publikováno v:
IEEE transactions on bio-medical engineering. 66(10)
Objective: Glargine 100 U/mL (Gla-100) and 300 U/mL (Gla-300) are long-acting insulin analogs providing basal insulin supply in multiple daily injection (MDI) therapy of type 1 diabetes (T1D). Both insulins require extensive testing to arrive at the
Autor:
Marcel Mischnik, Matthias Schäfer, Daniel Crowther, Manfred Hendlich, Jürgen Cox, Thomas Klabunde, Hans-Christoph Schneider, Matthias Mann, Francesca Sacco
Publikováno v:
Bioinformatics. 32:424-431
Motivation: Phosphoproteomics measurements are widely applied in cellular biology to detect changes in signalling dynamics. However, due to the inherent complexity of phosphorylation patterns and the lack of knowledge on how phosphorylations are rela
Autor:
Chiara Dalla Man, Claudio Cobelli, Clemens Giegerich, Thomas Klabunde, Roberto Visentin, Michele Schiavon
Publikováno v:
EMBC
The University of Virginia /Padova Type 1 Diabetes (TID) simulator has been widely used for testing artificial pancreas controllers, and, recently, novel insulin formulations and glucose sensors. However, a module describing the pharmacokinetics of t