Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Thomas Kjeldsen"'
Autor:
Elizabeth Holton, Edward Archer, James Fidal, Thomas Kjeldsen, Gideon Wolfaardt, Barbara Kasprzyk-Hordern
Publikováno v:
Environment International, Vol 164, Iss , Pp 107227- (2022)
Antimicrobial agent (AA) usage, excretion, and persistence are all important factors in association with the occurrence and dissemination of antimicrobial resistance. Urban water profiling was utilised in the Eerste River catchment (South Africa) to
Externí odkaz:
https://doaj.org/article/d929c9a6988045b99b34a630af7011bb
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.
Externí odkaz:
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Thomas Kjeldsen, Wouter F. J. Hogendorf, Christian W. Tornøe, Jonathan Anderson, Frantisek Hubalek, Carsten E. Stidsen, Jan L. Sorensen, Thomas Hoeg-Jensen
Publikováno v:
ACS Omega, Vol 5, Iss 31, Pp 19827-19833 (2020)
Externí odkaz:
https://doaj.org/article/fbe8339db2cc4c5188d391217970d406
Autor:
Erica Nishimura, Lone Pridal, Tine Glendorf, Bo Falk Hansen, František Hubálek, Thomas Kjeldsen, Niels Rode Kristensen, Anne Lützen, Karsten Lyby, Peter Madsen, Thomas Åskov Pedersen, Rasmus Ribel-Madsen, Carsten Enggaard Stidsen, Hanne Haahr
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
Introduction Insulin icodec is a novel, long-acting insulin analog designed to cover basal insulin requirements with once-weekly subcutaneous administration. Here we describe the molecular engineering and the biological and pharmacological properties
Externí odkaz:
https://doaj.org/article/75bb0be2610749feb0124a6abfc40035
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f3cf07c418ea4af69c46d62c9eb076b7
Publikováno v:
Geoforum Perspektiv, Vol 14, Iss 25 (2016)
In this paper we present our initial experiments with the new high quality digital elevation model, “Danmarks Højdemodel-2015” (DHM) exposed as an interactive 3D visualization on web and in virtual reality. We argue that such data has great oppo
Externí odkaz:
https://doaj.org/article/af24d3151a4941f9bb4d8065ead362cf
Autor:
Tine N Vinther, Mathias Norrman, Holger M Strauss, Kasper Huus, Morten Schlein, Thomas Å Pedersen, Thomas Kjeldsen, Knud J Jensen, František Hubálek
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30882 (2012)
An ingenious system evolved to facilitate insulin binding to the insulin receptor as a monomer and at the same time ensure sufficient stability of insulin during storage. Insulin dimer is the cornerstone of this system. Insulin dimer is relatively we
Externí odkaz:
https://doaj.org/article/56be5fcb4f9d42f782c421c1d91bc207
Autor:
Tine Glendorf, Louise Knudsen, Carsten E Stidsen, Bo F Hansen, Anne Charlotte Hegelund, Anders R Sørensen, Erica Nishimura, Thomas Kjeldsen
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e29198 (2012)
BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much s
Externí odkaz:
https://doaj.org/article/785dcfb71c16461ca83e1abc3e406c8d
Autor:
Tine Glendorf, Carsten E Stidsen, Mathias Norrman, Erica Nishimura, Anders R Sørensen, Thomas Kjeldsen
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20288 (2011)
BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent t
Externí odkaz:
https://doaj.org/article/5fec5f6e41e7484f95b13d42e1fa1362
Autor:
Hanne Haahr, Thomas Kjeldsen, Peter Kurtzhals, Peter Madsen, Erica Nishimura, Thomas Hoeg-Jensen, Jeppe Sturis, Eva Johansson
Publikováno v:
Trends in Pharmacological Sciences. 42:620-639
The life-saving discovery of insulin in Toronto in 1921 is one of the most impactful achievements in medical history, at the time being hailed as a miracle treatment for diabetes. The insulin molecule itself, however, is poorly amenable as a pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64c7f2bacc0f780d68910a496ecfb8d
https://doi.org/10.1016/j.tips.2021.05.005
https://doi.org/10.1016/j.tips.2021.05.005