Zobrazeno 1 - 10
of 331
pro vyhledávání: '"Thomas Kietzmann"'
Autor:
Kateryna Kubaichuk, Timo Seitz, Ulrich Bergmann, Virpi Glumoff, Daniela Mennerich, Thomas Kietzmann
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract Although there have been advances in understanding colorectal cancer (CRC) pathogenesis, significant gaps still exist, highlighting the need for deeper insights. Dysregulated protein homeostasis, including perturbations in the epidermal grow
Externí odkaz:
https://doaj.org/article/186504de91c5471498692eaf28c08760
Autor:
Gwenaëlle Le Menn, Keela Pikkarainen, Daniela Mennerich, Dominika Miroszewska, Thomas Kietzmann, Zhi Chen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionUbiquitin-specific proteases (USPs), a large subset of more than 50 deubiquitinase proteins, have recently emerged as promising targets in cancer. However, their role in immune cell regulation, particularly in T cell activation, different
Externí odkaz:
https://doaj.org/article/2abeeed136c54d528c613ce6ee85b70a
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103152- (2024)
Cellular magnetic field effects are assumed to base on coherent singlet-triplet interconversion of radical pairs that are sensitive to applied radiofrequency (RF) and weak magnetic fields (WEMFs), known as radical pair mechanism (RPM). As a leading m
Externí odkaz:
https://doaj.org/article/57bf73ef6b5d4d4eb3c3e49ac1d21fc0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Hypoxia-inducible factors (HIFs) are best known for their roles in the adaptation to low oxygen environments. Besides hypoxia, HIF-1/2 α-subunits are also regulated by various non-hypoxic stimuli including insulin which can act via the PI3K/protein
Externí odkaz:
https://doaj.org/article/f5eefb76b6b344298bdd3c4c69fab57f
Autor:
Thomas Kietzmann
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102753- (2023)
Vitamin C is unbeatable - at least when it comes to sales. Of all the vitamin preparations, those containing vitamin C sell best. This is surprising because vitamin C deficiency is extremely rare. Nevertheless, there is still controversy about whethe
Externí odkaz:
https://doaj.org/article/53e37b336077481c9af3d86509c5afd1
Autor:
Jouni Härkönen, Petri Pölönen, Ashik Jawahar Deen, Ilakya Selvarajan, Hanna-Riikka Teppo, Elitsa Y. Dimova, Thomas Kietzmann, Maarit Ahtiainen, Juha P. Väyrynen, Sara A. Väyrynen, Hanna Elomaa, Niko Tynkkynen, Tiia Eklund, Teijo Kuopio, Eva-Maria Talvitie, Pekka Taimen, Markku Kallajoki, Minna U. Kaikkonen, Merja Heinäniemi, Anna-Liisa Levonen
Publikováno v:
Redox Biology, Vol 61, Iss , Pp 102644- (2023)
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of
Externí odkaz:
https://doaj.org/article/9ac1335b051440bd822ee925a02cdeed
Autor:
Kateryna Kubaichuk, Thomas Kietzmann
Publikováno v:
Cells, Vol 12, Iss 12, p 1585 (2023)
Colorectal cancer ranks among the third most common human malignant diseases and is one of the leading causes of cancer-related deaths globally. Colon cancer cells are hypoxic and display disturbed protein homeostasis. Ubiquitin-ligase-initiated prot
Externí odkaz:
https://doaj.org/article/ade57f903c0746508e1c1bb9fc26d210
Autor:
Daniela Mennerich, Kateryna Kubaichuk, Ghulam S. Raza, Dominik C. Fuhrmann, Karl-Heinz Herzig, Bernhard Brüne, Thomas Kietzmann
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102243- (2022)
Metabolic adaptation and signal integration in response to hypoxic conditions is mainly regulated by hypoxia-inducible factors (HIFs). At the same time, hypoxia induces ROS formation and activates the unfolded protein response (UPR), indicative of en
Externí odkaz:
https://doaj.org/article/0a7ad601404d4fc294cbf9de12fb7e7e
Autor:
Fawzi Khoder-Agha, Thomas Kietzmann
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101888- (2021)
Reactive oxygen species (ROS) carry out prime physiological roles as intracellular signaling agents, yet pathologically high concentrations of ROS cause irreversible damage to biomolecules, alter cellular programs and contribute to various diseases.
Externí odkaz:
https://doaj.org/article/19a32e9a15944b8187d0ed1721b500af
Autor:
Elitsa Y. Dimova, Mirza Jakupovic, Kateryna Kubaichuk, Daniela Mennerich, Tabughang Franklin Chi, Filippo Tamanini, Małgorzata Oklejewicz, Jens Hänig, Nadiya Byts, Kari A. Mäkelä, Karl-Heinz Herzig, Peppi Koivunen, Ines Chaves, Gijsbertus van der Horst, Thomas Kietzmann
Publikováno v:
iScience, Vol 13, Iss , Pp 284-304 (2019)
Summary: The circadian clock and the hypoxia-signaling pathway are regulated by an integrated interplay of positive and negative feedback limbs that incorporate energy homeostasis and carcinogenesis. We show that the negative circadian regulator CRY1
Externí odkaz:
https://doaj.org/article/580f9c7556e84f51af3d2ce95d36c3cf