Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Thomas Kenneth Morgan"'
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Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents
Autor: Mark E. Sullivan, Thomas M. Argentieri, Robert P. Gomez, Thomas Kenneth Morgan, Gary B. Phillips, William C. Lumma, Joan M. Lind, Randall Lis
Publikováno v: Journal of medicinal chemistry. 35(4)
A series of novel arylpiperazines have been prepared in an attempt to incorporate both class II (beta-receptor blocking) and class III antiarrhythmic properties in a single molecule. The key step in the preparation of the new compounds involves a reg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1ae941855d9670f1d865112f182d8d
https://pubmed.ncbi.nlm.nih.gov/1347318
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3
2 An Overview of Class III Electrophysiological Agents: A New Generation of Antiarrhythmic Therapy
Autor: Thomas Kenneth Morgan, Mark E. Sullivan
Publisher Summary This chapter gives an overview of class III electrophysiological agents, which are considered a new generation of antiarrhythmic therapy. Arrhythmias can range from isolated PVC's, coupled beats, non-sustained ventricular tachyarrhy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f5f3cdcd97554b77aed8dda6d927714
https://doi.org/10.1016/s0079-6468(08)70005-5
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4
Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity
Autor: Joan M. Lind, Anthony J. Marisca, Gary Phillips, Mark E. Sullivan, Robert P. Gomez, Thomas Kenneth Morgan, Randall Lis, David D. Davey
Publikováno v: Journal of medicinal chemistry. 33(10)
Several (aryloxy)propanolamines and related compounds (i.e. 5-13, 16-18, 20-24, 27-33, 35, 37-39, 41, and 42) were synthesized and investigated for their class III electrophysiological activity and class II (beta-blocking) effects with use of in vitr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff7d6149b90e70c0afc5550c0ba78f5
https://pubmed.ncbi.nlm.nih.gov/1976812
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5
Synthesis and cardiac electrophysiological activity of aryl-substituted derivatives of the class III antiarrhythmic agent sematilide. Potential class I/III agents
Autor: Klaus Nickisch, Mark E. Sullivan, Thomas M. Argentieri, Thomas Kenneth Morgan, Gary B. Phillips, Ronald A. Wohl, Robert P. Gomez, Joan M. Lind
Publikováno v: Journal of medicinal chemistry. 33(2)
Twelve novel derivatives of the selective class III antiarrhythmic agent sematilide were prepared in an attempt to incorporate both class I and class III electrophysiological properties into a single molecule. Electrophysiological activity was determ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48a8a2303bf7fdaaa833b81a8c6959d
https://pubmed.ncbi.nlm.nih.gov/2299628
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6
Synthesis and Class III antiarrhythmic activity of (phenyl-2-butenyl)ammonium salts. Effect of conformation on activity
Autor: Mark E. Sullivan, Ronald A. Wohl, Chung Nan Wan, Anthony J. Marisca, David D. Davey, Thomas Kenneth Morgan, William C. Lumma, Samuel S. Wong, Robert P. Gomez, Martha Briggs
Publikováno v: Journal of Medicinal Chemistry. 29:1398-1405
The syntheses of seven 4-(substituted phenyl)but-2-en(or yn)yl quaternary ammonium salts and four related tertiary amines are described. The Meerwein arylation reaction was the preferred synthetic method for the required intermediate 1-aryl-4-halo-2-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69fbac3ec0ef6812fa30c74eab0bed0
https://doi.org/10.1021/jm00158a014
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7
Synthesis and cardiac electrophysiological activity of 2- and 3-[(substituted phenyl)alkyl]quinuclidines. Structure-activity relationships
Autor: Samuel S. Wong, Thomas M. Argentieri, Randall Lis, Thomas Kenneth Morgan, Mark E. Sullivan, Anthony J. Marisca
Publikováno v: Journal of medicinal chemistry. 30(12)
The syntheses and cardiac electrophysiological effects of 21 2- and 3-substituted quinuclidines and some quaternary ammonium derivatives are described. The 2-substituted quinuclidines 2-8 were prepared by alkylation of 2-methylene-3-quinuclidinone. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45910c32ee73579e363eefe39fd28c00
https://pubmed.ncbi.nlm.nih.gov/3681896
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9
Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega- hydroxyalkyl]-1H-imidazolium salts and related compounds
Autor: Ronald A. Wohl, Robert J. DeVita, Mark E. Sullivan, William C. Lumma, David D. Davey, Julius Diamond, Samuel S. Wong, Thomas Kenneth Morgan, Randall Lis
Publikováno v: Journal of medicinal chemistry. 30(4)
Novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega-hydroxyalkyl]-1H -imidazolium salts were synthesized and investigated for their class III electrophysiological activity on isolated canine cardiac Purkinje fibers and ventricular muscle ti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0416fb204162734656a3ca2362909940
https://pubmed.ncbi.nlm.nih.gov/3560162
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